Abstract:
:The imidazopyridine zolpidem has previously been shown to displace benzodiazepines from their receptors, with a preferential activity at BZ1 sites, and to exert hypnotic activity in man. Zolpidem's pharmacological profile includes anticonvulsant, antipunishment and behavioral depressant actions. However, unlike benzodiazepines, zolpidem exerts sedative actions at relatively low doses. In drug discrimination experiments differences between the internal stimuli produced by chlordiazepoxide and zolpidem were identified. These differences appeared to be qualitative rather than quantitative with the stimulus properties of zolpidem being related to the drug's sedative action. In condition where tolerance developed rapidly to the depressant activity of benzodiazepines little tolerance was seen with zolpidem. The behavioral profile of consistent with the suggestion that this compound may have selective sedative action produced by activity at a sub-type of benzodiazepine receptor.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Sanger DJ,Perrault G,Morel E,Joly D,Zivkovic Bdoi
10.1016/0031-9384(87)90359-3subject
Has Abstractpub_date
1987-01-01 00:00:00pages
235-40issue
3eissn
0031-9384issn
1873-507Xpii
0031-9384(87)90359-3journal_volume
41pub_type
杂志文章,评审abstract::By using the two-bottle, self-selection method it was found that an excess of thyroid hormone administration to rats increased water and sodium intake. Thyroidectomy changed the initial preference from water to sodium chloride. Oral treatment of the thyroidectomized rats with thyroid hormones brought salt ingestion ba...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90231-4
更新日期:1988-01-01 00:00:00
abstract::Monosodium glutamate (MSG) is an excitotoxin capable of both stimulating and lesioning neurons in circumventricular organs (CVOs) after systemic administration. In this study, MSG and equiosmotic concentrations of NaCl were administered subcutaneously to adult rats in order to observe the effects on food and water int...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90412-9
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Evidence of metabolic adaptations following weight loss is available in the literature. However, the impact of different degrees of caloric restriction on a comprehensive panel including energy expenditure (EE) and intake (EI), appetite, palatability and olfactory performance remains to be investigated. Acco...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2018.11.032
更新日期:2019-02-01 00:00:00
abstract::In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00046-5
更新日期:2003-04-01 00:00:00
abstract::Prenatal exposure to alcohol feminizes saccharin consumption patterns in adult male rats. To study the involvement of testosterone in this effect, testosterone propionate (TP) was administered to pregnant dams in an attempt to reverse that feminized saccharin consumption pattern in the male offspring. Female offspring...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90016-3
更新日期:1987-01-01 00:00:00
abstract::When animals are reared for conservational releases it is paramount to avoid reducing genetic and phenotypic variation over time. This requires an understanding of how diverging behavioural and physiological traits affect performance both in captivity and after release. In Atlantic salmon, emergence time from the spaw...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.03.028
更新日期:2017-06-01 00:00:00
abstract::A longitudinal behavioral study was performed in mice exposed to the bovine brain phospholipid phosphatidylserine (BC-PS) from birth until sixty days. Examination of treated and control pups revealed no effect of the treatment on body weight nor on sensorimotor reflexes. At one and two months of age, when placed in an...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90090-q
更新日期:1990-04-01 00:00:00
abstract::Rats weighing 45-50 g were fed 3 diets for 8 wk: a balanced control diet (CD) consisting of 4% fat (polyunsaturated/saturated fatty acids [P/S] ratio 2.9/1) and two fat-rich diets: polyunsaturated (UD)--P/S 7.6/1 and saturated (SD) P/S 0.3/1. After 8 wk feeding on the respective diets, rats were subjected to swimming ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90342-5
更新日期:1994-11-01 00:00:00
abstract::Thyroid hormones (TH) are essential for normal development and function of mammalian central nervous system (CNS); TH dysregulation has been implicated in several cognitive and behavioral deficits related to dysfunctions of neurotransmitter systems. In the present study, we investigated the effects of adult onset hypo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.06.016
更新日期:2016-10-01 00:00:00
abstract::Nootropic, antioxidant, and neuroprotective properties have been shown in a standardized ethanol extract of Ptychopetalum olacoides (POEE), a medicinal plant traditionally used by the Amazonian elderly population. It has been revealed that POEE mechanisms of action include anticholinesterase effects, and involve beta-...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.04.022
更新日期:2008-09-03 00:00:00
abstract::Although olfactory and vomeronasal projections to the olfactory bulb and to the rest of the brain are quite distinct, it is not clear how the functions of these two chemosensory systems differ. In these experiments we attempted to determine the roles of the main olfactory and vomeronasal sensory systems in mediating s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90214-o
更新日期:1990-11-01 00:00:00
abstract::Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. T...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.08.013
更新日期:2016-10-15 00:00:00
abstract::In the present work the existence of sex differences (Experiment 1) on the acquisition and extinction of a continuously reinforced response in a short and narrow runway (100 x 9 x 10 cm) were investigated. In addition to the investigation of the basic sex differences in Experiment 1, the effect of postpuberal gonadect...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90230-l
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The possible factors related to functional impairment and limitations in patients with temporomandibular disorders (TMDs) still need to be clarified because recovery of orofacial functions is a goal of their treatment. OBJECTIVE:To investigate whether chronic TMD patients had any changes in tongue strength,...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.112616
更新日期:2019-10-15 00:00:00
abstract::The taste responses to the "umami substances" such as monosodium glutamate (MSG), guanosine 5'-monophosphate (GMP) and inosine 5'-monophosphate (IMP) were recorded from the canine chorda tympani nerve. A large synergism was observed between MSG and the nucleotides in most mongrel dogs (type A dog). The extent of the s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90197-v
更新日期:1991-05-01 00:00:00
abstract::The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism, antiestrogens and antiandrogens. These compounds were tested in castrated birds whose sexual behavior had been activated ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90429-4
更新日期:1986-10-01 00:00:00
abstract::Daily fluid intakes were measured using two-bottle tests in female mice of inbred strains with high (BPH/2), normal (BPN/3) or low (BPL/1) blood pressure. The mice were offered a choice between water and different concentrations of NaCl (37.5-600 mM), KCl (1-400 mM), CaCl2 (1-100 mM) and quinine hydrochloride (0.003-1...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00069-9
更新日期:1998-06-01 00:00:00
abstract::Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90121-h
更新日期:1992-04-01 00:00:00
abstract::The present study examined responsiveness of newborn rats to a surrogate nipple providing fluids with basic tastes (sweet, sour, bitter and salty) and assessed the effects of this first gustatory experience on subsequent responding to the nipple itself (empty nipple) or the nipple providing water. Responsiveness (atta...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00672-2
更新日期:2002-06-01 00:00:00
abstract::Little information is available on the participation of the perineal striated muscles in female reproductive processes. Here, we describe the gross anatomy and innervation of two striated perineal muscles in the female rabbit, the bulbospongiosus (BSM) and ischiocavernosus (ISM), and analyze their reflex electromyogra...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00638-2
更新日期:2002-02-01 00:00:00
abstract::Environmental enrichment (EE) is an experimental model which is believed to counteract some of the effects induced by stressors, although few studies have exposed rodents simultaneously to EE and stress. Our aim was to compare the short- and long-term effects of different housing conditions in mice submitted to chroni...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.02.027
更新日期:2016-05-01 00:00:00
abstract::Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating. There is some evidence that ingested feathers affect gut function. The aim of the present study was to explore whether differences in intestinal microbial metabolites in laying hens with high and low levels of r...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.12.017
更新日期:2013-02-17 00:00:00
abstract::We used changes in body color and eyespot formation, two somatic indices of stress controlled mainly by catecholamine activity, to compare the reactions of dominant and subordinate male green anole lizards (Anolis carolinensis) to a nonsocial stressor, forced movement. Individual males were pretested by subjecting the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2003.10.009
更新日期:2004-01-01 00:00:00
abstract::Rats with either control operations or septal damage were pretrained on a VI 30-sec schedule and tested for response suppression ability on either an omission training (OT) task or on extinction. Septal damage enhanced barpressing on the VI 30-sec task. Animals with septal damage took longer to suppress responding on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(75)90228-0
更新日期:1975-08-01 00:00:00
abstract::The central effect of oxytocin (OT) on the aggressive behavior of lactating rats was studied. Female rats are more aggressive than nonlactating resident females, vigorously attacking conspecific intruder male or females. This behavior is considered important for pup protection against infanticide. The present work aim...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.05.002
更新日期:2005-06-30 00:00:00
abstract::The effects of deafferentation of the vomeronasal, olfactory or both systems of male mice on ultrasonic vocalizations in response to a male or female stimulus were analyzed. Regardless of the technique used, disruption of the vomeronasal system led to consistent reductions in ultrasonic vocalizations. Each animal rece...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90097-x
更新日期:1982-01-01 00:00:00
abstract::Single and multiple unit activity was recorded from the amygdaloid nuclei in awake unanesthestized rabbits during classical conditioning of the nictitating membrane (NM) response. Over half o the unit recordings from the amygdaloid complex demonstrated changes in firing rate following the presentation of the tone cond...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90306-8
更新日期:1984-04-01 00:00:00
abstract::Recurrent binge eating, or overeating accompanied by a sense of loss of control, is a major public health concern. Identifying similarities and differences among individuals with binge eating and those with other psychiatric symptoms and characterizing the deficits that uniquely predispose individuals to eating proble...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2017.03.037
更新日期:2017-07-01 00:00:00
abstract::Associative conditioning of satiety indicates that concentrated maltodextrin (cMD) may induce a mildly aversive visceral signal within 20 min of its ingestion, as well as satiating normally. Individuals' awareness of this adverse state was tested on ratings of statistically distinct descriptions of factors liable to s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.11.027
更新日期:2011-03-01 00:00:00
abstract::The aim of the study was to investigate the illuminance selected in the morning by subjects whose face was cooled and whose tympanic temperature has been lowered by 0.15-0.25 degrees C. The hypothesis tested was that a difference between the actual core temperature and its set point (load error) will influence the pre...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.physbeh.2003.12.015
更新日期:2004-03-01 00:00:00