The behavioral profile of zolpidem, a novel hypnotic drug of imidazopyridine structure.

Abstract:

:The imidazopyridine zolpidem has previously been shown to displace benzodiazepines from their receptors, with a preferential activity at BZ1 sites, and to exert hypnotic activity in man. Zolpidem's pharmacological profile includes anticonvulsant, antipunishment and behavioral depressant actions. However, unlike benzodiazepines, zolpidem exerts sedative actions at relatively low doses. In drug discrimination experiments differences between the internal stimuli produced by chlordiazepoxide and zolpidem were identified. These differences appeared to be qualitative rather than quantitative with the stimulus properties of zolpidem being related to the drug's sedative action. In condition where tolerance developed rapidly to the depressant activity of benzodiazepines little tolerance was seen with zolpidem. The behavioral profile of consistent with the suggestion that this compound may have selective sedative action produced by activity at a sub-type of benzodiazepine receptor.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Sanger DJ,Perrault G,Morel E,Joly D,Zivkovic B

doi

10.1016/0031-9384(87)90359-3

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

235-40

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(87)90359-3

journal_volume

41

pub_type

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