Consumption of electrolytes and quinine by mouse strains with different blood pressures.

Abstract:

:Daily fluid intakes were measured using two-bottle tests in female mice of inbred strains with high (BPH/2), normal (BPN/3) or low (BPL/1) blood pressure. The mice were offered a choice between water and different concentrations of NaCl (37.5-600 mM), KCl (1-400 mM), CaCl2 (1-100 mM) and quinine hydrochloride (0.003-1.0 mM). Compared with the normotensive strain, the hypertensive mice had higher water and total fluid intakes, and lower intakes of NaCl, KCl (only 200 mM) and quinine; the hypotensive mice had higher intakes of KCl (only 10-50 mM) and lower intakes of CaCl2 and quinine. These data suggest that fluid and salt intake are not linearly related to blood pressure, but are independently determined in these strains. Certain concentrations of the salts were preferred relative to water, which depended on mouse genotype: the BPN/3 and BPL/1 mice strongly preferred 37.5-150 mM NaCl, the BPL/1 mice preferred 10-100 mM KCl, and the BPN/3 mice preferred 1-10 mM CaCl2.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Bachmanov AA,Schlager G,Tordoff MG,Beauchamp GK

doi

10.1016/s0031-9384(98)00069-9

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

323-30

issue

3

eissn

0031-9384

issn

1873-507X

pii

S0031938498000699

journal_volume

64

pub_type

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