Abstract：
:Testosterone (T) is critical for maintaining male sexual behavior (MSB) in rodents, in part by altering protein synthesis in a well-defined neural circuit. The specific timing of protein synthesis essential for expression of MSB has never been investigated. We administered the protein synthesis inhibitor anisomycin (Ani) to castrated male Syrian hamsters treated sc with 100 μg T in an aqueous vehicle once weekly; this T regimen maintains MSB while elevating circulating T concentrations for only a few hours after each injection. Hamsters were injected s.c. with the vehicle or 12.5 mg Ani at one of several times relative to T administration; MSB was assessed once per week, 6 days after the previous T injection, for 5 weeks. Anisomycin administered 6-12 h after T injection significantly reduced the expression of sexual behavior, whereas Ani treatment between 3 h before and 3 h after T injection did not impair MSB. This experiment is the first to assess the specific timing of protein synthesis relative to a T pulse that is required for the expression of MSB. The demarcation of a critical interval for T-induced protein synthesis necessary for maintenance of MSB should facilitate specification of the genomic, proteomic, and biochemical cascades that subserve actions of T on male copulation.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Piekarski DJ,Seto T,Zucker Idoi
10.1016/j.physbeh.2011.08.025subject
Has Abstractpub_date
2012-01-18 00:00:00pages
215-9issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00420-3journal_volume
105pub_type
杂志文章abstract：:The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn o...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.06.007
更新日期：2008-09-03 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00674-6
更新日期：2002-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.10.028
更新日期：2012-11-05 00:00:00
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journal_title：Physiology & behavior
pub_type： 更正并重新发布的文章,杂志文章
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更新日期：1999-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
abstract：:Food preference and fish-attractive parameters were studied on 1000 15- to 18-month-old Nile crocodiles, using two-choice preference tests. All three experimental groups preferred live fish over dead fish and live chicks, while ground meat was the last choice. As for fish attractiveness, motion, freshness, size, color...
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pub_type： 杂志文章
doi：10.1016/0031-9384(91)90489-b
更新日期：1991-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1989-07-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2007-03-16 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2015-11-01 00:00:00
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更新日期：2017-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2017-10-01 00:00:00
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更新日期：2020-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1991-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
