Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.


:Rats pretrained in a conditioned avoidance (CAR) paradigm were put on eight potentially addictive drugs in drinking water at two dose levels each. Fluid intake and body weight, monitored during the drugged (addiction) and nondrugged (withdrawal) states, showed drug/dose-dependent fluctuations in most groups. Extinction and relearning trials were spread over both drug and nondrug phases. CAR-performance generally deteriorated in the early drug phase but improved to near normalcy during the late drug and withdrawal phases in all groups except for alcohol and barbiturate-treated one. Excluding amphetamine, low-dose morphine and phenobarbital groups, substantial extinction of CAR occurred during the drug phase only; these three groups, as well as the high-dose alcohol, barbiturates and medazepam ones, showed extinction during the nondrug phase also. The rate and extent of a second-order relearning neither differed significantly between the groups nor was truly contingent upon prior extinction. These results are discussed in the light of state-dependent learning, comparing them with those from another series of rats primarily trained under the influence of these addictive drugs.


Physiol Behav


Physiology & behavior


Banerjee U




Has Abstract


1975-09-01 00:00:00














  • Fatty acid responses in taste cells from obesity-prone and -resistant rats.

    abstract::One of the transduction mechanisms for the chemoreception of fat has been proposed to involve the inhibition of delayed rectifying potassium (DRK) channels by polyunsaturated free fatty acids (PUFAs). In the present study we have compared the responsiveness of fungiform taste receptor cells (TRCs) to fatty acids in ob...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Gilbertson TA,Liu L,Kim I,Burks CA,Hansen DR

    更新日期:2005-12-15 00:00:00

  • Zinc deficiency with reduced mastication impairs spatial memory in young adult mice.

    abstract::Sufficient oral microelements such as zinc and fully chewing of foods are required to maintain cognitive function despite aging. No knowledge exists about the combination of factors such as zinc deficiency and reduced mastication on learning and memory. Here we show that tooth extraction only in 8-week-old mice did no...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Kida K,Tsuji T,Tanaka S,Kogo M

    更新日期:2015-12-01 00:00:00

  • Examinations of the reward comparison hypothesis: The modulation of gender and footshock.

    abstract::The reward comparison hypothesis suggests that drugs of abuse-induced conditioned saccharin suppression intake is due to the reward value of drugs of abuse that outweighs that of a saccharin solution dissociating from the aversive LiCl-induced conditioned taste aversion (CTA). Huang and Hsiao (2008) provided some conf...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Huang AC,Wang CC,Wang S

    更新日期:2015-11-01 00:00:00

  • Conditioned place preference in female hamsters following aggressive or sexual encounters.

    abstract::Prior studies have demonstrated the utility of conditioned place preference procedures for examining the motivational or rewarding properties of behavior. The purpose of this experiment was to assess whether female Syrian hamsters would show evidence of conditioned place preference for aggression or sexual behaviors. ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Meisel RL,Joppa MA

    更新日期:1994-11-01 00:00:00

  • The effect of human chorionic gonadotropin on serum levels of testosterone, estradiol, and sexual behavior in young and old rhesus males.

    abstract::Sexual behavior and serum levels of testosterone (T) and estradiol (E) were examined in five young and six old rhesus males (Macaca mulatta) before and after the injection of 500 and 1000 IU of HCG. The serum levels of T and E increased in both young and old males after injection of either dose of HCG. Serum levels of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Phoenix CH,Walther AM,Jensen JN,Chambers KC

    更新日期:1989-10-01 00:00:00

  • Effects of neonatal oxytocin manipulation on development of social behaviors in mice.

    abstract::The oxytocin (OT) neural system is thought to be involved in the underlying mechanisms that guide the development of social behaviors. In the present study, we examined the effects of neonatal oxytocin manipulation in mice. Within 24 hours after birth, pups in the treatment group randomly received an intraperitoneal i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Mogi K,Ooyama R,Nagasawa M,Kikusui T

    更新日期:2014-06-22 00:00:00

  • Thermal comfort following immersion.

    abstract::Unlike thermal comfort in air, little research has been undertaken exploring thermal comfort around water sports. We investigated the impact of swimming and cooling in air after swimming on thermal comfort. After 10 min of swimming-and-resting cycles in 28°C water, volunteers wearing two types of garments or in swim b...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Guéritée J,Redortier B,House JR,Tipton MJ

    更新日期:2015-02-01 00:00:00

  • How are neuroticism and depression related to the psychophysiological stress response to acute stress in healthy older people?

    abstract::Neuroticism and depressive symptomatology have been related to a heightened and diminished physiological stress response, which may partly explain their negative relationship with health and wellbeing. Identifying factors that may increase disease vulnerability is especially relevant in older people, whose physiologic...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Puig-Perez S,Villada C,Pulopulos MM,Hidalgo V,Salvador A

    更新日期:2016-03-15 00:00:00

  • Calorie-restricted mice that gorge show less ability to compensate for reduced energy intake.

    abstract::Caloric restriction in mice can trigger gorging behaviour, which is characterized by periods of excessive food ingestion in a short time. Animals that gorge are thought to have a reduced metabolism compared to those that nibble their food over a longer period and might therefore be more able to compensate for reduced ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Hambly C,Simpson CA,McIntosh S,Duncan JS,Dalgleish GD,Speakman JR

    更新日期:2007-12-05 00:00:00

  • Corticosterone and prolactin responses to predictable and unpredictable novelty stress in rats.

    abstract::Prolactin along with corticosterone is a stress responsive hormone. The present study examined the effect of predictable and unpredictable psychological stress on corticosterone and prolactin secretion. Repeated unpredictable exposure to the novelty cage produced a more substantial increase in the level of corticoster...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Muir JL,Pfister HP

    更新日期:1986-01-01 00:00:00

  • Predator odor exposure increases food-carrying behavior in rats.

    abstract::To cover their energy demands, prey animals are forced to search for food. However, during foraging they also expose themselves to the risk of becoming the prey of predators. Consequently, in order to increase their fitness foraging animals have to trade-off efficiency of foraging against the avoidance of predation ri...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Wernecke KE,Brüggemann J,Fendt M

    更新日期:2016-02-01 00:00:00

  • Fine as North Dakota wine: sensory expectations and the intake of companion foods.

    abstract::Taste expectations can influence taste evaluations. It is not known, however, whether the environmental cues that influence taste expectations--such as suggestible names and brand labels--can have a referred impact on the intake volume of companion foods. Adult diners who ordered a prix-fixe restaurant meal were given...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Wansink B,Payne CR,North J

    更新日期:2007-04-23 00:00:00

  • Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice.

    abstract::To examine the role of interleukin-1beta (IL-1beta) in mediating sickness, we studied the effects of lipopolysaccharide (LPS) and IL-1beta on social behavior in endotoxin-responsive C3H/HeOuJ (OuJ) mice and endotoxin-resistant C3H/HeJ (HeJ) mice. Whereas LPS (1, 10 and 100 microg) depressed social behavior and body we...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Segreti J,Gheusi G,Dantzer R,Kelley KW,Johnson RW

    更新日期:1997-06-01 00:00:00

  • Beta-endorphin-like immunoreactivity levels in the hypothalamus, the periaqueductal grey and the pituitary of the DBA mouse: determination by ELISA and relationship to nociception.

    abstract::The present paper describes the development and application of an enzyme-linked immunosorbent assay (ELISA) for the assessment of beta-endorphin-like immunoreactivity (beta-ELIR) level in the hypothalamus, the periaqueductal grey (PAG) and the pituitary of DBA/2 mice that were subjected to mild social stress (aggressi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Külling P,Siegfried B,Frischknecht HR,Messiha FS,Pasi A

    更新日期:1989-07-01 00:00:00

  • Validity, reliability and usefulness of smartphone and kinovea motion analysis software for direct measurement of vertical jump height.

    abstract::Jumping is a simple exercise determined by several biomechanical and physiological factors. Measures of vertical jump height are common and easy to administer tests of lower limb muscle power that are carried out with several types of equipment. This study aimed to validate and address the usefulness of the combinatio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Pueo B,Penichet-Tomas A,Jimenez-Olmedo JM

    更新日期:2020-12-01 00:00:00

  • Alpha 2-adrenergic modulation of pancreatic glucagon secretion in rats.

    abstract::The present study was designed to clarify the mechanism of adrenergic modulation of pancreatic glucagon secretion in rats under physiological conditions by 1) epinephrine infusion alone or together with adrenergic blockers and 2) administration of adrenergic agonists. Intravenous infusion of epinephrine alone (1 micro...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Saito M,Saitoh T,Inoue S

    更新日期:1992-06-01 00:00:00

  • Consolidation and expression of a shock-induced odor preference in rat pups is facilitated by opioids.

    abstract::To support nipple attachment and huddling, rat pups must learn to approach and prefer maternal odor. Similar to other altricial species, rat pups have a sensitive period for learning this odor preference, which ends around postnatal day (PN) 10 and coincides with the emergence of walking. One characteristic of this se...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Roth TL,Sullivan RM

    更新日期:2003-01-01 00:00:00

  • Behavioral effects of 7-nitroindazole on hyperbaric oxygen toxicity.

    abstract::The aim of this study was to evaluate the role of nitric oxide (NO) upon hyperbaric oxygen (HBO) toxicity in male Sprague-Dawley rats during exposure to 0.5 MPa >99% O(2). In the first experiment, the selective neuronal NO synthase inhibitor 7-nitroindazole (7-NI) was injected intraperitoneally (ip) in 15 rats. Anothe...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Jellestad FK,Gundersen H

    更新日期:2002-08-01 00:00:00

  • Eating is a protected behavior even in the face of persistent pain in male rats.

    abstract::Feeding is critical for survival. Yet, patients with chronic pain often lose their appetite and eat less. We previously showed that ad libitum fed male rats continue to feed rather than withdraw from a brief noxious stimulus. This study examined the effects of a sustained noxious stimulus on feeding by testing ad libi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Foo H,Crabtree K,Thrasher A,Mason P

    更新日期:2009-06-22 00:00:00

  • Rearing and step climbing behavior of X-linked hypophosphatemic (Hyp) mice.

    abstract::Hyp mice are a model for X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. Previous reports indicate alterations in the nervous system of these mice. The present study examined rearing and step climbing behavior in Hyp mice in the staircase test. We found that male Hyp mice have large red...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Vaughn LK,Quock RM,Meyer RA Jr

    更新日期:1987-01-01 00:00:00

  • Taste cells in the gut and on the tongue. Their common, paraneuronal features.

    abstract::Chemoreception of foodstuff in the gut is performed by endocrine cells dispersed in the gut epithelium. They are bipolar cells extending an apical process to the gut lumen and releasing their messenger substances from the cell base in response to the apical stimuli. The cells share cell-biological features with neuron...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Fujita T

    更新日期:1991-05-01 00:00:00

  • Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test.

    abstract::17-β estradiol (E2) has been shown to modulate fear conditioning by influencing freezing behavior following re-exposure to either the conditioning context or a cue associated with shock. Fear-related behaviors other than freezing may be influenced differently by E2 replacement. Accordingly, the present study examined ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Gervais NJ,Jacob S,Brake WG,Mumby DG

    更新日期:2014-05-28 00:00:00

  • Altered responsiveness to ambiental stimuli in altered thyroidal states.

    abstract::Hypothyroidal rats produced by low iodine diet or propylthiouracyl (PTU) were less active in the open field and received fewer food reinforcements than controls in a lever press situation at both 22 degrees C and 1 degree C. The hypothyroid rats also pressed less when heat was the reinforcer. On the other hand, hypert...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Rial RV,Tur JA,Palmer AM,Tur J

    更新日期:1987-01-01 00:00:00

  • The relation of multiple hippocampal theta cell discharge rates to slow wave theta frequency.

    abstract::Multiple theta cells in the dentate granule cell area of the hippocampal formation of the freely moving rabbit were analyzed during three behavioral conditions: (1) voluntary motor patterns, termed Type 1 theta behaviors; (2) automatic motor patterns, termed Type 2 LIA behaviors; (3) alert immobility with presentation...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Bland BH,Seto MG,Rowntree CI

    更新日期:1983-07-01 00:00:00

  • Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats.

    abstract::Rats selectively display conditioned gaping reactions when re-exposed to flavours previously paired with nausea-inducing treatments and drugs that reduce nausea also reduce these reactions, suggesting that they represent a model of nausea-induced behavior in rats. However, these reactions rely upon learning, they are ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Tuerke KJ,Winters BD,Parker LA

    更新日期:2012-02-01 00:00:00

  • Circadian rhythms and patterns of running-wheel activity, feeding and drinking behaviors of old male rats.

    abstract::Running-wheel activity of 7 young adult male rats (3 to 6.5 months of age) and 11 old male rats (22 to 34 months of age), feeding behavior of 10 each of young adult and old male rats and drinking behavior of 6 each of young adult and old male rats were recorded. Circadian rhythms were lost in 2, 6 and 1 old rats respe...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Peng MT,Kang M

    更新日期:1984-10-01 00:00:00

  • Infantile (handling) stimulation and behavior in young Roman high- and low-avoidance rats.

    abstract::The effect of infantile handling stimulation on exploratory and emotional behavior of Roman high- and low-avoidance (RHA/Verh and RLA/Verh) weanling rats was investigated. Postnatally handled and nonhandled, 4-week-old males and females from both psychogenetically selected lines were exposed to a hexagonal tunnel maze...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Fernández-Teruel A,Escorihuela RM,Driscoll P,Tobeña A,Bättig K

    更新日期:1991-09-01 00:00:00

  • Medial prefrontal cortex oxytocin-opioid receptors interaction in spatial memory processing in rats.

    abstract::Medial prefrontal cortex (mPFC), a forebrain structure, is involved in many brain functions such as learning and memory. In the present study, the effect of intra-mPFC microinjection of oxytocin, atosiban, morphine and naloxone was investigated on memory processing. Two guide cannulas were implanted into the right and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Salighedar R,Erfanparast A,Tamaddonfard E,Soltanalinejad F

    更新日期:2019-10-01 00:00:00

  • Positive effects of acarbose in the diabetic rat are not altered by feeding schedule.

    abstract::We previously demonstrated that chronic dietary treatment with acarbose, an alpha-glucosidase inhibitor, improves glucose homeostasis in the streptozotocin (STZ)-induced diabetic rat. In this study we evaluated the effects of 4 weeks of acarbose treatment on glucose homeostasis in STZ-diabetic rats for both meal-fed (...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Wright BE,Vasselli JR,Katovich MJ

    更新日期:1998-03-01 00:00:00

  • Annual rhythm and hormonal control of predatory behavior in female ferrets.

    abstract::The predatory behavior of female ferrets shows seasonal fluctuations which appear to be affected by estradiol. Under natural lighting conditions in the laboratory the annual rhythm of the behavior was observed during anestrus, estrus, pregnancy, pseudopregnancy and lactating period. Females in heat failed to show pred...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Harrer S,Schmidt WJ

    更新日期:1986-01-01 00:00:00