Androsterone sulfate increases dentate gyrus population spike amplitude following tetanic stimulation.

Abstract:

:We studied the effects of the androgenic hormone, androsterone sulfate, a 17-ketosteroid, on long term potentiation in the dentate gyrus (DG) of urethane anesthesized rats. Intravenous injection of 10 mg of the hormone dissolved in Nutralipid produced a significant increase of the population spike (PS), but not of the excitatory post-synaptic potentials (EPSP). The results are discussed in terms of the potential enhancement that androsterone sulfate may have on memory as was described for one of its parent compounds, dehydroepiandrosterone (DHEA) and its potential use as an antidepressant.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Urbanoski K,Harris J,Gijsbers K,Dubrovsky B

doi

10.1016/s0031-9384(00)00354-1

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

435-40

issue

5

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(00)00354-1

journal_volume

71

pub_type

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