CNS GLP-1 regulation of peripheral glucose homeostasis.

Abstract:

:Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Sandoval D

doi

10.1016/j.physbeh.2008.04.018

subject

Has Abstract

pub_date

2008-08-06 00:00:00

pages

670-4

issue

5

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(08)00109-1

journal_volume

94

pub_type

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