Effect of amino acid supplementation to a low-protein diet on brain neurotransmitters and memory-learning ability of rats.

Abstract:

:The supplementation of methionine and threonine to a 10% soy protein isolate diet caused sharp decreases in the concentrations of brain tryptophan, serotonin and 5HIAA (5-hydroxyindole acetic acid) (e.g., in the hypothalamus, hippocampus, amygdala, locus coeruleus and brain stem). The serum tryptophan ratio (i.e., the ratio of the serum concentration of tryptophan to the sum of the concentrations of other large neutral amino acids, such as tyrosine, phenylalanine, leucine, isoleucine, valine and methionine) significantly decreased. The changes in catecholamines were small on the supplementation of amino acids to the soy protein diet. In the brightness-discrimination learning test, the number of total responses (R+, correct; R-, incorrect) of rats fed the amino acid-supplemented diet increased as compared with that of rats fed the nonsupplemented diet. The correct response ratio in the primary learning test did not change, but in the reverse learning test, the response ratio of rats fed the amino acid-supplemented diet increased. Therefore, it may be considered that the learning ability is correlated with the nutritional state.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Yokogoshi H,Nomura M

doi

10.1016/0031-9384(91)90587-e

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

1227-32

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(91)90587-E

journal_volume

50

pub_type

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