Abstract：
:Fatigue is common in a host of neurological and psychiatric disorders including depression and often continues unabated even after primary symptoms of disease are treated. Its high estimated prevalence combined with the lack of effective medicines has engaged the preclinical research community to search for fatigue models. The present review briefly summarizes the most common animal models that have been brought forward along with some of the associated pharmacological validation data. Like all preclinical models, these models have issues that need to be appreciated in the generation and interpretation of data for the purposes of translation to human disease; specifically, there are deficiencies in construct validity, a lack of medicines that effectively address residual fatigue symptoms, and difficulties in defining specificity with respect to drug effects on fatigue per se. Nonetheless, existing animal models of fatigue arguably serve the valuable purpose of encouraging research in this large area of unmet medical need. Data from these models are predicted to engender human experimentation and the further development of improved model systems.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Stutz PV,Golani LK,Witkin JMdoi
10.1016/j.physbeh.2018.11.042subject
Has Abstractpub_date
2019-02-01 00:00:00pages
300-305eissn
0031-9384issn
1873-507Xpii
S0031-9384(18)30501-8journal_volume
199pub_type
杂志文章,评审abstract：:Grooming and penile reflexes were studied in male rats that were restrained in supine position with the penile sheath retracted or were free to copulate with sexually receptive females. In Experiment 1 there was a reliable concordance in supine males between the tendency to groom and the tendency to display penile ref...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90219-3
更新日期：1988-01-01 00:00:00
abstract：:The purpose of the present study was a description of hormonal profiles in female prairie voles (Microtus ochrogaster) in estrus that was induced by male exposure versus postpartum estrus. Hormonal profiles are reported in sexually naive females and in sexually experienced females, as a function of varying amounts of ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90195-9
更新日期：1989-12-01 00:00:00
abstract：:The purpose of this study was to examine the interchangeability of a new perceived recovery status scale (PRS) of 100 points through a comparison to the original 10-point version. This study also aimed to test the interchangeability of CR100 scale (Borg's rate of perceived exertion scale) in comparison to the CR10. Tw...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112641
更新日期：2019-10-15 00:00:00
abstract：PURPOSE:To describe and evaluate behavioral models of binge-type eating. DATA IDENTIFICATION:Studies were identified using Medline and hand searches of bibliographies of identified articles. STUDY SELECTION:Isomorphic studies were selected that were judged to have some measure of construct validity. DATA EXTRACTION:...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2004.04.036
更新日期：2004-08-01 00:00:00
abstract：:In previous studies we showed that higher viscosity resulted in lower ad libitum intake and that eating rate is an important factor. In this study we aimed to explore the effect of viscosity on the gastro-intestinal hormones ghrelin, CCK-8 and GLP-1. Thirty-two subjects (22+/-2 y, BMI 21.9+/-2.2 kg/m(2)) participated ...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2009.02.001
更新日期：2009-04-20 00:00:00
abstract：:An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 day...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90311-q
更新日期：1990-08-01 00:00:00
abstract：:Psychological stressors are known to increase core body temperature (T(c)) in laboratory animals. Such single stress-induced hyperthermic responses are typically monophasic, as T(c) returns to baseline within several hours. However, studies on the effects of repeated psychological stress on T(c) are limited. Therefore...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.04.027
更新日期：2010-08-04 00:00:00
abstract：:The effect of eating on defecation behaviour was investigated in four 20-30 kg pigs. Rectal distention stimulation was performed pre- and postprandially at 10 cm from the anus with a 5 cm latex balloon. Volume was increased in steps of 10 ml up to 200 ml of air or until balloon defecation. Dependent measures were volu...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90190-d
更新日期：1992-03-01 00:00:00
abstract：:Eighteen ovariectomized ring doves (Streptopelia risoria) received subcutaneous silastic implants of either testosterone propionate (TP), 5 alpha-dihydrotestosterone propionate (DHTP) or cholesterol. Birds were paired daily for 1-hr with intact males. Eleven days after implantation the pairs were observed. Both TP and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90330-5
更新日期：1984-04-01 00:00:00
abstract：:To examine the role of interleukin-1beta (IL-1beta) in mediating sickness, we studied the effects of lipopolysaccharide (LPS) and IL-1beta on social behavior in endotoxin-responsive C3H/HeOuJ (OuJ) mice and endotoxin-resistant C3H/HeJ (HeJ) mice. Whereas LPS (1, 10 and 100 microg) depressed social behavior and body we...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00611-7
更新日期：1997-06-01 00:00:00
abstract：:Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is rapidly gaining popularity among recreational users as a hallucinogenic "designer drug." Unfortunately, much remain unknown about the consequences of its use on neuropsychological development or behavior. During one of two adoles...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.01.021
更新日期：2011-05-03 00:00:00
abstract：:Male hooded rats were castrated and implanted with Silastic capsules (1.57 mm i.d.; 3.18 mm o.d.) having a testosterone-filled space 0, 7, 22, 60, or 90 mm long. All animals were returned to their original group cages for a three-week period to allow hormone concentrations and behavioral tendencies to stabilize. Each ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90336-3
更新日期：1990-09-01 00:00:00
abstract：:Obesity and chronic stress have been considered important public health problems that affect millions of people worldwide. Our aim was to analyze the effect of obesity associated with chronic stress on neurobehavioral parameters in female rats, considering that the association of these syndromes can enhance the negati...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.07.016
更新日期：2015-11-01 00:00:00
abstract：:The present study was carried out to determine possible panicogenic effects of strychnine administered in subconvulsive doses to rats. Two experiments were conducted to assess two major features of panic in animal models: panic-related flight (through the observation of wild running [WR]) and defensive fights. In the ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2003.10.003
更新日期：2004-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy m...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112760
更新日期：2020-02-01 00:00:00
abstract：:The vigilance reaction is characterized by a large bradycardia, a pressor response, and inspiratory apnea in anesthetized rabbits and the inhibition of movement in conscious rabbits. This affective response pattern can be elicited by electrical stimulation of the dorsolateral hypothalamus (the hypothalamic vigilance a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00004-8
更新日期：1997-09-01 00:00:00
abstract：:The effects of daily single injections of 20 mg/kg cocaine on locomotor activity, core temperature, and heart rate were determined by radiotelemetry. There was a progressive increase in locomotor activity over the 30-day treatment period. Cocaine-induced activity was 9-12-fold greater than that of saline-treated anima...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00250-8
更新日期：1996-11-01 00:00:00
abstract：:This study evaluated the utility of the compound nerve action potential (CAP) and spinal nociceptive withdrawal (R3) reflex in identifying and quantifying peripheral afferent activity evoked by sural nerve stimulation in humans. The results of this work demonstrate that currents less than or equal to that which elicit...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90374-o
更新日期：1993-06-01 00:00:00
abstract：:The objective of this study was to determine whether humans could detect long-chain fatty acids when these lipid molecules are delivered to the oral cavity by edible taste strips. For suprathreshold studies, up to 1.7 μmol of stearic acid or linoleic acid was incorporated into 0.03 mm thick, one-inch square taste stri...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.04.006
更新日期：2012-07-16 00:00:00
abstract：:Toddler's diarrhea may be an allergic disease and its recurrences can be avoided with education to "internal spontaneity" in feeding, i.e., by education to a limited and reproducible decrease in eating incentives at the onset of meals. Serum IgE was thus investigated in 16 experimental children in a random comparison ...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0031-9384(91)90248-m
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Appetite regulating properties of foods are usually investigated under laboratory conditions, whereas in real life, foods are consumed under at home conditions. The objective of this study was to compare the acute effects of breakfasts when tested in a laboratory condition and in an at home condition. Appeti...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2018.06.024
更新日期：2018-10-01 00:00:00
abstract：:Rats adrenalectomized (ADX) on day 11 of life display enhanced brain growth due, at least in part, to a stimulation of cell proliferation and myelinogenesis. The present study investigated some functional consequences of this treatment. Rats were ADX or sham-operated (SHAM) on postnatal day 11 and then tested in adult...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90040-6
更新日期：1988-01-01 00:00:00
abstract：:Nongenetic heredity cases have been described in man, as well as in animals, and relationships between parents and offspring seem to play an important role in this transmission. In mice, mothering type could be nongenetically heritable by a latent learning close to mechanism. As mothering style clearly influences emot...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00566-2
更新日期：2001-10-01 00:00:00
abstract：:We examined changes of epinephrine, norepinephrine, and cortisol levels in 24-h urine accompanying emotional behavior in cats such as restlessness, threat, and quiet biting attack elicited by electrical stimulation of specific sites within the hypothalamus. Although norepinephrine remained unchanged with restlessness ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00233-u
更新日期：1995-03-01 00:00:00
abstract：:Studies from the last two decades have pointed to multiple mechanisms of fear. For responding to predators, there is a group of highly interconnected hypothalamic nuclei formed by the anterior hypothalamic nucleus, the ventromedial hypothalamic nucleus and the dorsal premammillary nucleus—the predator-responsive hypot...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.10.013
更新日期：2015-12-01 00:00:00
abstract：:Insulin was chronically administered to rats to determine its effect on the daily changes in food intake and body weight. Animals received regular insulin via 14-day osmotic minipumps in doses of 0.0, 0.5, 1.0, 3.0, and 5.0 IU/day treated either with (+GLU) or without glutamic acid (-GLU). Previous studies have shown ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90021-f
更新日期：1991-10-01 00:00:00
abstract：:Oral cavity edge perception acuity relative to the fingertip has previously been evaluated by the utilization of cognitively-loaded, stereognostic methods. However, with the lack of connection of the tongue to the visual association cortex, there is concern the superior acuity of the fingertip may be attributable to t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113035
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:'Low-carb' diets have been suggested to be effective in body weight (BW) management. However, these diets are relatively high in protein as well. OBJECTIVE:To unravel whether body-weight loss and weight-maintenance depends on the high-protein or the 'low-carb' component of the diet. DESIGN:Body-weight (BW)...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.08.004
更新日期：2012-10-10 00:00:00
abstract：:There is evidence that alterations in heart rate and blood pressure variability (BPV) are associated with cardiovascular disease. We used a mice model to investigate the effects of acute and chronic stress on blood pressure variability (BPV) and heat rate variability (HRV). Shaker stress was given acutely (5 min, 150 ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.08.004
更新日期：2004-10-30 00:00:00
abstract：:Cardiomyopathic hamsters (CMH) develop heart disease early in life which leads to congestive heart failure and death as these hamsters age. We have previously shown that living in constant light or other non-24-h light-dark (LD) cycles can increase longevity in these hamsters, and the current experiment examined poten...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00250-3
更新日期：1997-11-01 00:00:00
