Abstract：
:The present study was carried out to determine possible panicogenic effects of strychnine administered in subconvulsive doses to rats. Two experiments were conducted to assess two major features of panic in animal models: panic-related flight (through the observation of wild running [WR]) and defensive fights. In the first one, 20 adult male Wistar rats were injected with six different doses of strychnine ranging from 0.5 to 4.0 mg/kg. After 15 min of free observation, the animals were submitted to high-intensity acoustic stimulation and the incidence of WR was recorded. Higher doses of strychnine (above 2.5 mg/kg) easily evoked seizures, but lower doses raised the incidence of WR in a dose-dependent manner. The most effective dose for WR (1.5 mg/kg) was used in the second experiment, in which we investigated the effects of strychnine on sleep-deprivation-induced fights (SDIFs) that have defensive characteristics. For this purpose, 40 subjects were submitted to 5 days of REM-sleep deprivation by the single-platform method and were then assigned into two groups, i.e., strychnine vs. control. After the injections, the animals were observed in social groupings for SDIF recordings over a period of 60 min. The strychnine-treated groups had more SDIF than the control groups (P<.05, Mann-Whitney U test). We conclude that the high level of neural excitability promoted by partial blockade of the glycinergic system can contribute to the manifestation of panic reactions.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
de Paula HM,Hoshino Kdoi
10.1016/j.physbeh.2003.10.003subject
Has Abstractpub_date
2004-01-01 00:00:00pages
459-64issue
4eissn
0031-9384issn
1873-507Xpii
S0031938403003044journal_volume
80pub_type
杂志文章abstract：:The present study describes changes of response enhancement of hippocampal field potentials in slices of kindled rats using different methods to induce long-lasting potentiation. Eight-week-old male Wistar rats were subjected to pentylenetetrazol (PTZ) kindling induced by intraperitoneal injection of 45 mg/kg once eve...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2009-03-23 00:00:00
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更新日期：2004-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2006-08-30 00:00:00
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更新日期：1982-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.07.020
更新日期：2008-10-20 00:00:00
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journal_title：Physiology & behavior
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更新日期：2015-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
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更新日期：1989-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90047-6
更新日期：1982-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-11-01 00:00:00
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更新日期：1994-11-01 00:00:00
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更新日期：2006-01-30 00:00:00
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更新日期：1989-03-01 00:00:00
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更新日期：1991-12-01 00:00:00
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更新日期：2003-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
