Effect of low frequency electrical stimulation on seizure-induced short- and long-term impairments in learning and memory in rats.

Abstract:

:Kindled seizures can impair learning and memory. In the present study the effect of low-frequency electrical stimulation (LFS) on kindled seizure-induced impairment in spatial learning and memory was investigated and followed up to one month. Animals were kindled by electrical stimulation of hippocampal CA1 area in a semi-rapid manner (12 stimulations per day). One group of animals received four trials of LFS at 30s, 6h, 24h, and 30h following the last kindling stimulation. Each LFS trial was consisted of 4 packages at 5min intervals. Each package contained 200 monophasic square wave pulses of 0.1ms duration at 1Hz. The Open field, Morris water maze, and novel object recognition tests were done 48h, 1week, 2weeks, and one month after the last kindling stimulation respectively. Kindled animals showed a significant impairment in learning and memory compared to control rats. LFS decreased the kindling-induced learning and memory impairments at 24h and one week following its application, but not at 2week or 1month after kindling. In the group of animals that received the same 4 trials of LFS again one week following the last kindling stimulation, the improving effect of LFS was observed even after one month. Obtained results showed that application of LFS in fully kindled animals has a long-term improving effect on spatial learning and memory. This effect can remain for a long duration (one month in this study) by increasing the number of applied LFS.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Esmaeilpour K,Sheibani V,Shabani M,Mirnajafi-Zadeh J

doi

10.1016/j.physbeh.2016.11.001

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

112-121

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(16)30476-0

journal_volume

168

pub_type

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