Scheduled feeding caused activation of dopamine metabolism in the striatum of rats.

Abstract:

:The effects of a time-restricted feeding schedule on dopamine (DA) release and its metabolites output in the striatum of freely moving rats were studied. Rats had access to food for only 2 h daily for 7 successive days. On the 1st or 7th day, the extracellular concentrations of DA, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in the ventrolateral striatum were measured by in vivo brain microdialysis during 2 h of exposure to food-related stimuli followed by 2 h of access to food. Extracellular concentrations of DA and its metabolites did not change during the period of exposure to food-related stimuli or during feeding on the 1st day. On the 7th day, extracellular DOPAC and HVA concentrations increased significantly during 2 h of feeding, but not during exposure to food-related stimuli, compared with basal levels. Extracellular DA concentration did not change significantly. These results indicate that scheduled feeding caused activation of DA metabolism in the ventrolateral striatum and facilitate feeding-related motor activity in feeding behavior.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Inoue K,Kiriike N,Okuno M,Ito H,Fujisaki Y,Matsui T,Kawakita Y

doi

10.1016/0031-9384(93)90028-e

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

177-81

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90028-E

journal_volume

53

pub_type

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