The renin angiotensin system and the metabolic syndrome.

Abstract:

:The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic syndrome. It may serve as a causal link among obesity and several co-morbidities. Drugs that reduce the synthesis or action of angiotensin-II (A-II; the primary effector peptide of the RAS) have been used to treat hypertension for decades and, more recently, clinical trials have determined the utility of these pharmacological agents to prevent insulin resistance. Moreover, there is evidence that the RAS contributes to body weight regulation by acting in various tissues. This review summarizes what is known of the actions of the RAS in the brain and throughout the body to influence various metabolic disorders. Special emphasis is given to the role of the RAS in body weight regulation. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

de Kloet AD,Krause EG,Woods SC

doi

10.1016/j.physbeh.2010.03.018

subject

Has Abstract

pub_date

2010-07-14 00:00:00

pages

525-34

issue

5

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(10)00156-3

journal_volume

100

pub_type

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