Abstract:
:This study analyzed in Balb/C mice the effects of individual housing on behavior, serum corticosterone and resistance to Ehrlich tumor growth. Mice (60 days old) were individually (IH) or grouped housed (G) (10-12 animals/cage) for 14-21 days. The 1st day of the housing condition was considered experimental day 1 (ED1). Results showed that on ED21, IH mice, when compared to G mice, presented no differences on corticosterone serum levels when kept undisturbed; however, an increased level of this hormone was observed in IH mice after an immobilization stress challenge. An increased time spent in the plus-maze closed arms and a decreased time in the open arms were also observed in IH mice. When compared to G animals, after inoculation with 10(5) Ehrlich tumor cells on ED1, IH mice presented an increase in volume of ascitic fluid and number of tumor cells. The survival time of IH mice was also shorter than that measured in G animals. Furthermore, IH mice injected with a different number of tumor cells on ED1 always presented increased Ehrlich tumor cells than G group. Interestingly, these effects were not observed when the tumor cells injection was done on ED4. These results suggest that individual-housing conditions induce an altered immune-endocrine response and, at the same time, decrease animals' resistance to Ehrlich tumor growth. It is proposed that the neural link between the behavioral and immunological changes observed after the stress of individual housing might involve the activation of the HPA axis.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Palermo-Neto J,Fonseca ES,Quinteiro-Filho WM,Correia CS,Sakai Mdoi
10.1016/j.physbeh.2008.07.006subject
Has Abstractpub_date
2008-10-20 00:00:00pages
435-40issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(08)00219-9journal_volume
95pub_type
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journal_title:Physiology & behavior
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2004-10-30 00:00:00
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pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-04-10 00:00:00
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更新日期:2005-01-31 00:00:00
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