Lesions of the globus pallidus and striatum attenuate ketocyclazocine-induced feeding.

Abstract:

:A large body of evidence suggests that endogenous opioids are involved in the regulation of feeding. As the striatum and globus pallidus have relatively high concentrations of opioid receptors, these areas are possible sites of action for the stimulatory effects of opiates on feeding. To test these possibilities, male rats were lesioned bilaterally in the globus pallidus or striatum. Nocturnal food intake was then measured after the subcutaneous administration of the opiate antagonist, naloxone (0-10 mg/kg). Spontaneous daytime intake was measured after the subcutaneous administration of the kappa opiate agonist ketocyclazocine (0-10 mg/kg). Neither pallidal nor striatal lesions affected the sensitivity of naloxone in reducing food intake. On the other hand, both lesioned groups were 10-100 times less sensitive to the stimulatory effects of ketocyclazocine. These results suggest that the globus pallidus and striatum may be target areas for the stimulatory effects of exogenous opiates on food intake. Additionally, the relationship of these areas to the dopaminergic nigrostriatal tract suggests that feeding regulation may involve an interaction between dopaminergic and opioid systems.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Gosnell BA,Morley JE,Levine AS

doi

10.1016/0031-9384(84)90153-7

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

349-55

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(84)90153-7

journal_volume

33

pub_type

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