Effects of chronic cannabinoid exposure during adolescence on reward preference and mPFC activation in adulthood.

Abstract:

:Cannabis is one of the most commonly used drugs among adolescents, with initial use beginning between the ages of 12 to 17. Although often perceived as a 'soft drug', both short- and long-term use have been associated with numerous adverse outcomes, including cognitive impairment, increased risk of substance abuse, and heightened risk of psychosis or schizophrenia in individuals with a predisposition. Further, the severity of these impairments is closely linked to initiation of use, i.e. earlier use increases risk. It has been suggested that adolescent vulnerability to the adverse consequences of cannabis use is due to ongoing brain development occurring during this time. Indeed, the adolescent brain continues to be remodeled well into adolescence and early adulthood, particularly in the prefrontal cortex (PFC). The medial prefrontal cortex (mPFC) has been implicated in reward processing and decision-making and alterations in mPFC development due to adolescent cannabis exposure could impair these functions. To model the effects of cannabis on mPFC function, we administered the synthetic cannabinoid WIN 55, 212-2 (WIN) to male and female rats from postnatal day 30-60. Once animals reached adulthood, we used a Probabilistic Reward (PR) choice task to elicit PFC activity and measure how patterns of activity to task-related events were modulated by adolescent WIN-treatment. Adult animals showed subtle effects of WIN-treatment on choice patterns. During task performance, mPFC activity elicited by lever press at the time of choices and reward delivery following choices were reduced in WIN-treated animals. This lasting effect of WIN suggests an impairment of the maturation of excitatory-inhibitory balance of signals in mPFC during adolescence, which may alter executive function into adulthood.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Jacobs-Brichford E,Manson KF,Roitman JD

doi

10.1016/j.physbeh.2018.12.006

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

395-404

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(18)31096-5

journal_volume

199

pub_type

杂志文章
  • Histamine plays no part in schedule-induced polydipsia in the rat.

    abstract::Twelve Sprague-Dawley male albino rats were tested with or without combined antagonism of peripheral H1 (using 2 mg/kg dexbrompheniramine IP) and H2 (using 32 mg/kg cimetidine IP) receptors for histamine prior to (a) drinking after 2.5 mg/kg histamine SC, (b) drinking after 24-hr water deprivation, and (c) drinking du...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90385-3

    authors: Kraly FS,Coogan LA,Mashkuri PL,Kellman SA

    更新日期:1985-05-01 00:00:00

  • Light-dark and food restriction cycles in sea bass: effect of conflicting zeitgebers on demand-feeding rhythms.

    abstract::Sea bass, a fish species characterized by its dualistic feeding pattern, was investigated to study the synchronizing effect of light and food on the demand-feeding rhythm. Nocturnal and diurnal sea bass, both in groups and individually, were exposed to restricted-feeding (RF) and light-dark (LD) cycles of different pe...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)00116-z

    authors: Sánchez-Vázquez FJ,Zamora S,Madrid JA

    更新日期:1995-10-01 00:00:00

  • From mindless eating to mindlessly eating better.

    abstract::Plate shapes and package sizes, lighting and layout, color and convenience: these are a few of hidden persuaders that can contribute to how much food a person eats. This review first posits that these environmental factors influence eating because they increase consumption norms and decrease consumption monitoring. Se...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2010.05.003

    authors: Wansink B

    更新日期:2010-07-14 00:00:00

  • Hyperactivity and obesity: the interaction of social isolation and cafeteria feeding.

    abstract::Rats were reared in social isolation or in social groups of 4 or 5 rats per cage from weaning and were fed either a lab chow diet or a diet of 4 palatable foods (cafeteria diet), in addition to the lab chow. The hyperactivity of isolation-reared rats appears to be a reactivity to novel environmental stimuli, since it ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90112-3

    authors: Sahakian BJ,Burdess C,Luckhurst H,Trayhurn P

    更新日期:1982-01-01 00:00:00

  • A comparative study of the effect of starvation regimes on the foraging behavior of Portunus trituberculatus and Charybdis japonica.

    abstract::Predation of manila clams (Ruditapes philippinarum) by swimming crabs (Portunus trituberculatus) and Japanese stone crabs (Charybdis japonica) was compared in the laboratory under different starvation regimes by a video recording analysis system, and the mechanism of foraging behavior differences between them combined...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.07.011

    authors: Sun Y,Wang F,Dong S

    更新日期:2015-11-01 00:00:00

  • Refeeding after acute food restriction: differential reduction in preference for ethanol and ethanol-paired flavors in selectively bred rats.

    abstract::Rats' voluntary ethanol intake varies with dispositional factors and energy status. The joint influences of these were of interest here. We previously reported that rats selectively bred for high voluntary saccharin intake (HiS) consume more ethanol and express more robust conditioning of preference for flavors paired...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.12.001

    authors: Dess NK,Chapman CD,Cousins LA,Monroe DC,Nguyen P

    更新日期:2013-01-17 00:00:00

  • Genetic obestiy: estrogenic influences on the body weight and food intake of lean and obese adult Zucker (fa/fa) rats.

    abstract::The effects of chronic estrogen withdrawal and subsequent hormone replacement on the feeding and body weight of adult lean and genetically obese Zucker rats were investigated. Following confirmation of a delay in the vaginal canalization of the fatty rat, subgroups of each genotype received either ovariectomy or sham ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(79)90130-6

    authors: Gale SK,Van Itallie TB

    更新日期:1979-07-01 00:00:00

  • Vena caval bombesin infusion decreases spontaneous meal size in undisturbed rats.

    abstract::The amphibian tetradecapeptide bombesin (BN) decreases food intake in both humans and animals. Studies have typically examined the effects of BN on scheduled meals in deprived subjects. To investigate the properties of this peptide under more naturalistic conditions, we examined the effects of BN in spontaneously feed...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02136-1

    authors: Rushing PA,Gibbs J,Geary N

    更新日期:1996-02-01 00:00:00

  • Postprandial sleep and thermogenesis in normal men.

    abstract::Twelve normal male subjects were given low- (16.77 kj/kg) and high- (54.49 kj/kg) calorie liquid carbohydrate lunch meals on 4 days, during which measures of sleep EEG, thermogenesis (heat production), core body temperature, and skin surface temperature were obtained. On 2 days subjects were required to remain awake, ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90267-6

    authors: Zammit GK,Ackerman SH,Shindledecker R,Fauci M,Smith GP

    更新日期:1992-08-01 00:00:00

  • Change in the hedonic value of an aversive stimulus in the presence of a pre-exposed odor.

    abstract::Rats exhibit a sensitive period from the time of birth until postnatal day 10 during which they develop preferences for odors even if those odors are paired with a moderately aversive stimulus. It is still unknown whether pre-exposure to an odor produces alterations on intake responses of basic tastants, and on other ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.12.041

    authors: Kamenetzky GV,Suárez AB,Pautassi RM,Mustaca AE,Nizhnikov ME

    更新日期:2015-09-01 00:00:00

  • Time-of-day effects on postural control and attentional capacities in children.

    abstract::The present study aimed to examine the effect of time-of-day on postural control, body temperature, and attentional capacities in 5-6 year old children. Twelve male children (5-6-year-old) were asked to maintain an upright bipedal stance on a force platform with eyes open (EO) and eyes closed (EC) at 07:00, 10:00, 14:...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.01.029

    authors: Baccouch R,Zarrouk N,Chtourou H,Rebai H,Sahli S

    更新日期:2015-04-01 00:00:00

  • Relating oral physiology and anatomy of consumers varying in age, gender and ethnicity to food oral processing behavior.

    abstract::The aim of this study was to link parameters describing oral physiology and anatomy of consumers varying in age, gender and ethnicity to food oral processing behavior. Three groups of healthy consumers were compared: Dutch, Caucasian adults (18-30 yrs, n =32), Chinese, Asian adults (18-30 yrs, n =32) and Dutch, Caucas...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112766

    authors: Ketel EC,de Wijk RA,de Graaf C,Stieger M

    更新日期:2020-03-01 00:00:00

  • A bitter taste in the mouth: The role of 6-n-propylthiouracil taster status and sex in food disgust sensitivity.

    abstract::We investigated the relationship between perceived bitterness, food disgust sensitivity, and sex. Participants completed the 8-item Food Disgust Scale and a 6-n-propylthiouracil (PROP) taster test and were categorised as PROP non-tasters, medium-tasters, or supertasters. An analysis of variance of between-subject fact...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.02.036

    authors: Ammann J,Hartmann C,Siegrist M

    更新日期:2019-05-15 00:00:00

  • Oral processing assessed by M-mode ultrasound imaging varies with food attribute.

    abstract::Ultrasonic imaging was used to quantify oral movements made during the oral processing of foods while subjects assessed the intensity of the sensory attributes, thick, creamy, sweet and bitter. A series of four stimuli were prepared with high and low viscosities and high and low sweetness. Over five sessions, subjects...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.physbeh.2006.05.021

    authors: de Wijk RA,Wulfert F,Prinz JF

    更新日期:2006-08-30 00:00:00

  • Hypophagia follows the initial hyperphagia produced by 2-deoxy-D-glucose in rats.

    abstract::The glucose analogue 2-deoxy-D-glucose (2DG) inhibits glucose metabolism and causes a rapid increase in food consumption in most species. This increase is most apparent during the first 6 postinjection hours, although it may persist as long as 10 hr. There are no published descriptions of alterations in food consumpti...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(79)90142-2

    authors: Thompson CI,Zagon IS,McLaughlin PJ

    更新日期:1979-07-01 00:00:00

  • How to quench your thirst. The effect of water-based products varying in temperature and texture, flavour, and sugar content on thirst.

    abstract::The sensation of thirst plays an important role in the consumption of water or other fluids to rehydrate the body in order to keep bodily functions working properly. An increase in saliva secretion, wetting the mouth by ingestion of liquids, and cooling and sour components in products can alleviate this sensation alre...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.08.007

    authors: van Belzen L,Postma EM,Boesveldt S

    更新日期:2017-10-15 00:00:00

  • Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation.

    abstract::The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimen...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02271-6

    authors: Meerlo P,Overkamp GJ,Benning MA,Koolhaas JM,Van den Hoofdakker RH

    更新日期:1996-07-01 00:00:00

  • Prenatal stress alters maternal aggression in mice.

    abstract::Prenatal stress (heat and restraint) reduced pregnancy-induced and elevated postpartum aggression in Rockland-Swiss (R-S) albino female mice. Though prenatally-stressed females were indistinguishable from control animals with respect to parental behavior during the virgin state, the former displayed slightly lower lev...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90252-1

    authors: Kinsley C,Svare B

    更新日期:1988-01-01 00:00:00

  • Entrainment of the rat motor activity rhythm: effects of the light-dark cycle and physical exercise.

    abstract::The circadian system is believed to be composed of a population of oscillators that couple together and generate a single rhythm. If this coupling is not strong enough, the circadian system can be dissociated into two or more groups of oscillators, and this is manifested in a dissociation of the overt rhythm into at l...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00241-9

    authors: Cambras T,Vilaplana J,Campuzano A,Canal-Corretger MM,Carulla M,Díez-Noguera A

    更新日期:2000-08-01 00:00:00

  • Aerobic exercise with blood flow restriction affects mood state in a similar fashion to high intensity interval exercise.

    abstract::We investigated the acute effects of aerobic exercise with blood flow restriction (BFR) on mood state in American football athletes. Twenty-two male American football athletes were randomly assigned to three experimental conditions: 1) aerobic exercise (AE: 40% VO2max), 2) aerobic exercise with BRF (AE + BFR: 40% VO2 ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2019.112677

    authors: da Silva JCG,Silva KF,Domingos-Gomes JR,Batista GR,da Silva Freitas ED,Torres VBC,do Socorro Cirilo-Sousa M

    更新日期:2019-11-01 00:00:00

  • The type of implicit motive enactment is modulated by sex hormones in naturally cycling women.

    abstract::Sex hormones have been reported to dynamically modulate the expression of implicit motives, a concept that has previously been thought to be relatively stable over time. This study investigates to what extent the need for affiliation, power, and achievement, as well as the form of enactment of these needs as measured ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.09.016

    authors: Ball A,Wolf CC,Ocklenburg S,Brüne M,Wolf OT,Güntürkün O,Pinnow M

    更新日期:2014-01-17 00:00:00

  • Sympathetic mediation of stress and aggressive competition: plasma catecholamines in free-living male tree lizards.

    abstract::The sympathetic nervous system and adrenal catecholaminergic tissue act to prepare an animal for "fight or flight" by release of catecholamines into synapses and plasma. However, few studies have measured plasma catecholamines in nonmammalian vertebrates and none have measured them in free-living animals. We report pl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00500-8

    authors: Matt KS,Moore MC,Knapp R,Moore IT

    更新日期:1997-05-01 00:00:00

  • Aversion induced by electrical stimulation of the mesencephalic locomotor region in the intact and freely moving rat.

    abstract::Electrical stimulation of the so-called "mesencephalic locomotor region" (MLR) in the acute mesencephalic and restrained rat is known to induce locomotion. In the intact and freely moving rat, electrical stimulation of an area coextensive with MLR is reported to elicit an apparently aversive type of behavioral respons...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90127-p

    authors: Depoortere R,Sandner G,Di Scala G

    更新日期:1990-03-01 00:00:00

  • Methyl xanthine, adenosine, and human taste responsivity.

    abstract::The influences of three methyl xanthines (MX) on human taste responsivity, caffeine, theophylline, and theobromine, were examined using blind control procedures. Taste responsivity in the same subjects was determined using the matching procedure described by Schiffman (Study 1) and the whole-mouth procedure described ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90347-5

    authors: Brosvic GM,Rowe MM

    更新日期:1992-09-01 00:00:00

  • Effects of attention and rewarded activity on immune parameters and wound healing in pigs.

    abstract::Challenging animals with a demanding situation they are able to cope with and where they are rewarded may be a source of positive emotions and possibly of increased welfare. In order to test if this results in changes of immunological parameters and wound healing, 56 pigs (7-20 weeks of age), housed in groups of 8 ani...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.07.001

    authors: Ernst K,Tuchscherer M,Kanitz E,Puppe B,Manteuffel G

    更新日期:2006-10-30 00:00:00

  • Spatial memory under acute cold and restraint stress.

    abstract::This study examined spatial memory as measured by radial arm maze (RAM) performance after exposure to two stress conditions and a normothermic-unrestrained control condition. Male Fischer 344 rats were trained on the win-shift RAM procedure for 7 days, by which time they achieved asymptotic performance. The next day, ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00091-2

    authors: Stillman MJ,Shukitt-Hale B,Levy A,Lieberman HR

    更新日期:1998-07-01 00:00:00

  • Different ontogenetic patterns of testosterone production reflect divergent male reproductive strategies in chimpanzees and bonobos.

    abstract::Male reproductive effort is often strongly related to levels of the steroid hormone testosterone. However, little research has examined whether levels of testosterone throughout development might be tied to individual or species differences in the reproductive strategies pursued by adult males. Here, we tested the hyp...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.03.003

    authors: Wobber V,Hare B,Lipson S,Wrangham R,Ellison P

    更新日期:2013-05-27 00:00:00

  • The nociceptive response of stressed and lithium-treated rats is differently modulated by different flavors.

    abstract::Pleasant and unpleasant flavors and odors can modulate pain perception, and the efficacy of sweet flavors in reducing pain seems to be related to its hedonic value. Chronic variate stress paradigm is a model of depression, and is suggested to induce anhedonia. We observed previously that lithium may prevent behavioral...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.04.004

    authors: de Vasconcellos AP,Nieto FB,Fontella FU,da Rocha ER,Dalmaz C

    更新日期:2006-07-30 00:00:00

  • Neural transplants. effects On startle responses in neonatally MSG-treated rats.

    abstract::Neonatal monosodium glutamate (MSG) treatment has been associated with dysfunctions in stress responses. Therefore, the present study aimed at examining the acoustic startle response (ASR) in MSG-treated rats and the effects of fetal neural transplantation. Male and female rats were given MSG (4 mg/g) or saline on alt...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(99)00256-5

    authors: Yang FC,Connor J,Patel A,Doat MM,Romero MT

    更新日期:2000-05-01 00:00:00

  • Muscle damage and inflammation biomarkers after two ultra-endurance mountain races of different distances: 54 km vs 111 km.

    abstract::The aims of this study were 1) to describe the effects of a 54 km and 111 km ultra-endurance mountain race on the biomarkers of muscle damage and inflammation, 2) to compare the effects between the two races regarding the biomarkers of muscle damage and inflammation. Sixteen ultra-endurance amateur runners volunteered...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.10.002

    authors: Rubio-Arias JÁ,Ávila-Gandía V,López-Román FJ,Soto-Méndez F,Alcaraz PE,Ramos-Campo DJ

    更新日期:2019-06-01 00:00:00