Abstract：
:The amphibian tetradecapeptide bombesin (BN) decreases food intake in both humans and animals. Studies have typically examined the effects of BN on scheduled meals in deprived subjects. To investigate the properties of this peptide under more naturalistic conditions, we examined the effects of BN in spontaneously feeding rats. Undisturbed, ad lib-fed male rats (n = 9) with chronic inferior vena caval catheters were infused with saline vehicle and each of 3 doses (2, 4, and 8 micrograms/kg) of BN in counterbalanced order with intervening noninfusion days. Infusions were remotely activated at the onset of the first nocturnal meal and continued for 3 min (34 microliters/min), delivery being completed within the first 2 min of infusion. Feeding was measured via electronic balances linked to a computer. All doses of the peptide significantly decreased the size and duration of the first nocturnal meal. In addition, 4 and 8 micrograms/kg of BN significantly shortened the intermeal interval from the end of the first meal to the beginning of the second meal. Despite this, the satiety ratio (interval/meal size) tended to increase after BN and was significantly increased by the highest dose (8 micrograms/kg), thus indicating a sustained satiety action of the peptide. In summary, these results show that brief, meal-contingent intravenous infusions of BN potently inhibit spontaneous feeding in undisturbed rats.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Rushing PA,Gibbs J,Geary Ndoi
10.1016/0031-9384(95)02136-1subject
Has Abstractpub_date
1996-02-01 00:00:00pages
307-10issue
2eissn
0031-9384issn
1873-507Xpii
0031-9384(95)02136-1journal_volume
59pub_type
杂志文章abstract：:When animals are reared for conservational releases it is paramount to avoid reducing genetic and phenotypic variation over time. This requires an understanding of how diverging behavioural and physiological traits affect performance both in captivity and after release. In Atlantic salmon, emergence time from the spaw...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90413-i
更新日期：1991-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：1998-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2008.05.003
更新日期：2008-09-03 00:00:00
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更新日期：2014-03-14 00:00:00
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pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.03.017
更新日期：2014-05-10 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1996-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.04.017
更新日期：2017-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90195-9
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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更新日期：2016-09-01 00:00:00
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更新日期：2019-08-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1998-02-01 00:00:00
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更新日期：1997-07-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2015-01-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1992-03-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2017-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1989-06-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1986-01-01 00:00:00
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更新日期：2018-10-01 00:00:00
