Dimethyl disulfide mimics the effects of milk on fetal behavior and responsiveness to cutaneous stimuli.

Abstract:

:This study examined the behavioral responses of near-term rat fetuses to a range of chemosensory fluids that resemble constituents of milk or are present in the context of suckling immediately after birth. Milk and dimethyl disulfide (DMDS), a constituent of pup saliva that promotes postnatal nipple attachment, were effective in altering fetal motor activity (increased mouthing and rearlimb movements after infusion), and producing changes in fetal responsiveness to perioral cutaneous stimulation (reduced incidence of facial wiping). The behavioral effects of DMDS were reversed by naloxone and the kappa receptor antagonist nor-binaltorphimine diHCl, suggesting kappa opioid involvement in these behavioral changes. The existence of prenatal responsiveness to DMDS suggests that this substance may function as a semiochemical during the neonatal period.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Smotherman WP,Robinson SR

doi

10.1016/0031-9384(92)90411-t

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

761-5

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90411-T

journal_volume

52

pub_type

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