Abstract：
OBJECTIVE:Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects are plenty applicable to females, since clinical and experimental studies concerning physical exercise and epilepsy are largely performed in males. Females are worthy of special attention due to gender specific particularities such as hormonal cyclical rhythm and possible pregnancy. Therefore, this study aimed to investigate the impact of two types of exercise programs (Forced and Voluntary) in female Wistar rats submitted to temporal lobe epilepsy induced by pilocarpine. METHODS:Animals were divided into four groups: Control (healthy), Epilepsy, Epilepsy/Forced (exercise in a treadmill) and Epilepsy/Voluntary (free access to wheel). Behavioral and histological analyses were evaluated among groups. RESULTS:Voluntary exercise was able to reduce seizure frequency and anovulatory estrous cycle occurrence. Yet, both types of exercise attenuated the mossy fiber sprouting in dentate gyrus. CONCLUSION:Our results indicate that voluntary exercise exerts a positive effect on epilepsy in female gender. Further investigations are necessary to better elucidate mechanisms involved in these responses, since these effects do not act in the same manner in male and female rats.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Vannucci Campos D,Lopim GM,da Silva DA,de Almeida AA,Amado D,Arida RMdoi
10.1016/j.physbeh.2016.12.040subject
Has Abstractpub_date
2017-03-15 00:00:00pages
120-126eissn
0031-9384issn
1873-507Xpii
S0031-9384(16)30896-4journal_volume
171pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1977-07-01 00:00:00
