Abstract：
:Inner ear is critical for the development of motion sickness (MS). The present work was designed to test the role of aquaporins (AQPs) in inner ear in MS. After repetitive stimulus of rotation, the MS symptom was steadily alleviated in mice. After repetitive stimulus of rotation, several AQPs mRNA levels including AQP1, AQP2, AQP3, AQP4, AQP6, AQP7, and AQP9 in the inner ears of mice were analyzed. It was found that AQP1 mRNA level was increased remarkably, which was reconfirmed by Western blotting analysis. In addition, the relationship between AQP1 expression and MS sensitivity was studied and it was shown that AQP1 mRNA level was negatively related to MS index in mice. We sought to examine the function of AQP1 in inner ear using an RNAi approach to reduce the AQP1 protein expression in vivo. It was first observed that AQP1 knockdown in inner ear resulted in a significant increase of MS sensitivity in mice. In conclusion, after repetitive stimulus of rotation, the alleviation of MS symptom in mice was, at least in part, due to the upregulation of AQP1 expression in inner ear. In addition, the sensitivity to MS in mice was, at least in part, dependent on the expression of AQP1 in inner ear. AQP1 in inner ear plays an important role in the development of MS, and might be a potential target for the prevention or management of MS.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Huang YD,Xia SW,Dai P,Han DYdoi
10.1016/j.physbeh.2011.07.031subject
Has Abstractpub_date
2011-10-24 00:00:00pages
749-53issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00383-0journal_volume
104pub_type
杂志文章abstract：:Gustatory avoidance studies normally focus on the diminished occurrence of a consummatory behavior as the primary dependent variable. Several reports have described behaviors which accompany this gustatory avoidance response but no attempt has been made to automate collection of such data. In the following studies lit...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：1986-01-01 00:00:00
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更新日期：1989-02-01 00:00:00
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journal_title：Physiology & behavior
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doi：10.1016/0031-9384(86)90223-4
更新日期：1986-01-01 00:00:00
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更新日期：2016-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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更新日期：1998-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2000-07-01 00:00:00
