Abstract：
:Acute infections lead to alterations in behavior, collectively known as sickness behavior, which includes reduction in locomotion, food ingestion, sexual and social behavior, environmental exploration, and sleep profile. Although generally seen as undesired, sickness behavior represents a conserved strategy for animals to overcome disease. Aging process is associated with a variety of changes in immunity, which are referred to as immunosenescence, and include higher mortality by infectious diseases. Few works studied sickness behavior display in old animals. Thus, we sought to investigate the display of sickness related behaviors on aged mice. Adult (3-6 months old), middle-aged (12-15 m) and aged mice (18-22 m) were treated with i.p. LPS (200 microg/kg) and their behaviors were assessed in the open field and in the elevated plus-maze. Exploratory activity was similar in aged mice treated or not with LPS in both apparati. In the open field, locomotion remained at baseline levels; in the elevated plus-maze, there was a time-dependent decrease in motor activity.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Kinoshita D,Cohn DW,Costa-Pinto FA,de Sá-Rocha LCdoi
10.1016/j.physbeh.2008.10.018subject
Has Abstractpub_date
2009-02-16 00:00:00pages
328-32issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(08)00334-Xjournal_volume
96pub_type
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