Clozapine: strong antiaggressive effects with minimal motor impairment.

Abstract:

:Clinical studies have shown clozapine to be effective in the treatment of schizophrenia and associated with an extremely low incidence of extrapiramidal side effects. Diverse studies indicate that clozapine is an atypical neuroleptic with a preferential activity on the mesolimbic structures and a lower affinity for striatal D2 receptors than the classical antipsychotics. The purpose of this study was to assess the behavioral properties of clozapine, especially its effects on aggressive and motor behaviors. Individually housed male mice of the OF1 strain were exposed to anosmic "standard opponents" 30 minutes after the last drug administration. One category of animals received a single IP dose of the compound (0.2, 0.5, 1 or 1.5 mg/kg). Another category received daily doses (0.5, 1 or 1.5 mg/kg) for 21 days. Encounters were videotaped and behavior evaluated using an ethologically based analysis. Clozapine, in the acute treatment condition, produced a significant decrease in "attack" and "threat" behaviors without "immobility" being significantly increased. These results suggest a rather specific antiaggressive action of the compound with little motor impairment. In the chronic administration, no significant change in aggressive behavior was observed which may be attributed to the development of some degree of tolerance.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Garmendia L,Sánchez JR,Azpiroz A,Brain PF,Simón VM

doi

10.1016/0031-9384(92)90202-d

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

51-4

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90202-D

journal_volume

51

pub_type

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