Plasticity of bladder reflex pathways during postnatal development.

Abstract:

:Neuroanatomical and electrophysiological techniques have provided insights into the organization of the spinal cord circuitry and the neurotransmitter mechanisms involved in primitive voiding reflexes in neonatal animals. Patch clamp studies of unitary synaptic transmission in spinal cord slice preparations indicate that developmental plasticity in sacral parasympathetic reflex pathways is due in part to alterations in the glutamatergic excitatory transmission between interneurons and parasympathetic preganglionic neurons. It is proposed that these synaptic changes are due to competition between segmental and supraspinal inputs. Thus, synaptic remodeling in the sacral parasympathetic nucleus is likely to be an important factor in the postnatal maturation of voiding reflexes.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

de Groat WC

doi

10.1016/s0031-9384(02)00919-8

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

689-92

issue

4-5

eissn

0031-9384

issn

1873-507X

pii

S0031938402009198

journal_volume

77

pub_type

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