Placental and fetal growth restriction, size at birth and neonatal growth alter cognitive function and behaviour in sheep in an age- and sex-specific manner.

Abstract:

:Intrauterine growth restriction and slow neonatal growth in humans are each associated with poorer learning, memory and cognitive flexibility in childhood and adulthood. The relative contributions of pre- and post-natal growth to cognitive outcomes are unclear, however. We therefore compared performance in learning, memory and reversal tasks using a modified Y-maze at 18 and 40 weeks of age in offspring of placentally-restricted (PR: 10 M, 13 F) and control (23 M, 17 F) ovine pregnancies. We also investigated relationships between size at birth, neonatal growth rates and cognitive outcomes. PR had limited effects on cognitive outcomes, with PR males requiring more trials to solve the initial learning task than controls (P=0.037) but faster completion of reversal tasks in both sexes at 18 weeks of age. In males, neonatal growth rate correlated inversely with numbers of trials and total time required to solve memory tasks at 40 weeks of age. In females, bleat frequency in the first reversal task at 18 weeks of age correlated positively with birth weight (r=0.734, P<0.05) and neonatal growth rate (r=0.563, P<0.05). We conclude that PR induces limited effects on cognitive outcomes in sheep, with some evidence of impaired learning in males, but little effect on memory or cognitive flexibility in either sex. Rapid neonatal growth predicted improved memory task performance in males, suggesting that strategies to optimize neonatal growth may have long-term cognitive benefits but that these may be sex-specific.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Hunter DS,Hazel SJ,Kind KL,Liu H,Marini D,Giles LC,De Blasio MJ,Owens JA,Pitcher JB,Gatford KL

doi

10.1016/j.physbeh.2015.08.042

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1-10

issue

Pt A

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(15)30096-2

journal_volume

152

pub_type

杂志文章
  • Intermittent access to sweet high-fat liquid induces increased palatability and motivation to consume in a rat model of binge consumption.

    abstract::Binge eating disorders are characterized by discrete episodes of rapid and excessive food consumption. In rats, giving intermittent access to sweet fat food mimics this aspect of binge eating. These models typically employ solid food; however, the total amount consumed depends on motivation, palatability and satiety, ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.03.005

    authors: Lardeux S,Kim JJ,Nicola SM

    更新日期:2013-04-10 00:00:00

  • Does sex mediate the affective response to high intensity interval exercise?

    abstract::High intensity interval exercise (HIIE) is identified as an alternative to moderate intensity continuous exercise (MICE) due to its similar effects on outcomes including maximal oxygen uptake and glycemic control. Nevertheless, its widespread implementation in adults is questioned because acute HIIE elicits more avers...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.02.005

    authors: Astorino TA,Sheard AC

    更新日期:2019-05-15 00:00:00

  • Effects of septal lesions on shock thresholds in weanling male and female rats.

    abstract::Twenty-four-day old weanling male and female rats were either lesioned in the septal area, gonadectomized, lesioned and gonadectomized, or untreated. Tests for reactivity to electric shock were conducted at 26 and at 40 days of age. Neither males nor females showed any effect of the lesions are measured by flinch and ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(77)90046-4

    authors: Stewart J,Atkinson S,Cygan D

    更新日期:1977-11-01 00:00:00

  • Separation of the tremorous and muscular rigidity components of the ethanol withdrawal syndrome in the rat.

    abstract::The alcohol withdrawal syndrome consists of a kinetic tremor, the tremorous component, and a peculiar abnormality of tone called asterixis, the muscular rigidity component. The severity of the ethanol withdrawal syndrome in the rat is generally assessed by the severity of the tremors. 3-Hydroxybutyrate suppresses the ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90123-x

    authors: Derr RF,Derr MI

    更新日期:1986-01-01 00:00:00

  • Food deprivation and the facilitatory effects of estrogen in female hamsters: the LH surge and locomotor activity.

    abstract::Two experiments investigated short-term food deprivation effects on neuroendocrine processes influenced by estrogen. These studies were prompted by prior work indicating that food deprivation increased the number of immunocytochemically identified cells containing estradiol receptors in the medial preoptic area of ova...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00133-3

    authors: Mangels RA,Jetton AE,Powers JB,Wade GN

    更新日期:1996-09-01 00:00:00

  • Animal models for the study of the effect of prolonged stress on lactation in rats.

    abstract::The suppressive effect of stress on lactation is well acknowledged. Animal models used to study this problem have used primarily acute stressors. As such, they are not adequate for the study of the effect of prolonged stress on lactation. This study aimed at developing a paradigm(s) in rats for the study of the effect...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.05.004

    authors: Lau C,Simpson C

    更新日期:2004-09-15 00:00:00

  • Neuropeptide gamma: a mammalian tachykinin endowed with potent antidipsogenic action in rats.

    abstract::Neuropeptide gamma (NP gamma) is a 21 aminoacid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. NP gamma possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secre...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)00071-p

    authors: Polidori C,Staffinati G,Perfumi MC,de Caro G,Massi M

    更新日期:1995-09-01 00:00:00

  • The effects of subdiaphragmatic vagotomy on circadian corticosterone rhythmicity in rats with continuous or restricted food access.

    abstract::Plasma corticosteroid circadian periodicity was determined in three groups of individual adult male rats. Categories were: post-subdiaphragmatic vagotomy, sham-operated, and controls. Blood was sampled every 4 hours over a 48-hour period with ad lib feeding and after a 13-day period on daytime (0930--1330) restriction...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90194-9

    authors: Moreira AC,Krieger DT

    更新日期:1982-05-01 00:00:00

  • Does the timing of estrogen administration after castration affect its ability to preserve sexual interest in male rats?--exploring the critical period hypothesis.

    abstract::Loss of libido is a major side effect that reduces the quality of life of prostate cancer patients on androgen-deprivation therapy. Estrogen restores sexual interest to some extent in castrated male mammals; however, the beneficial effects of estrogen vary greatly among different studies. We investigated whether the t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.12.010

    authors: Wibowo E,Wassersug RJ

    更新日期:2013-02-17 00:00:00

  • LPS fever in old rats depends on the ambient temperature.

    abstract::In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(03)00046-5

    authors: Peloso ED,Florez-Duquet M,Buchanan JB,Satinoff E

    更新日期:2003-04-01 00:00:00

  • Quality and intensity of binary odor mixtures.

    abstract::The perceived intensity and quality of binary mixtures consisting of the common but dissimilar odorants, benzaldehyde (almond), eugenol (cloves), propionic acid (vinegar) and (-)-carvone (spearmint), were determined over a wide range of environmentally relevant concentrations. Consistent data were obtained from each o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90118-5

    authors: Laing DG,Panhuber H,Willcox ME,Pittman EA

    更新日期:1984-08-01 00:00:00

  • Blindness and play fighting in juvenile rats.

    abstract::Play behavior of blinded and sighted juvenile rats was measured using the brief paired-encounter procedure. Dyads of sighted-sighted, blind-blind, or sighted-blind rats were observed in a large or small chamber on alternate days for ages 28 through 43 days. Blinded rats played as frequently as sighted rats regardless ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90003-x

    authors: Bierley RA,Hughes SL,Beatty WW

    更新日期:1986-01-01 00:00:00

  • Olfactory coding in the monkey lateral hypothalamus: behavioral and neurochemical properties of odor-responding neurons.

    abstract::The activity of glucose-sensitive (GS) and glucose-insensitive (GIS) neurons was recorded in the lateral hypothalamic area (LHA) of monkeys during olfactory stimulation, a conditioned alimentary bar press task, and microelectrophoretic application of catecholamines. Olfactory stimuli evoked response of 88% of the GS n...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90117-0

    authors: Karádi Z,Oomura Y,Nishino H,Aou S

    更新日期:1989-06-01 00:00:00

  • The effect of social environment on the immune response of female common voles in matriarchal laboratory groups.

    abstract::We used the hemagglutination test to investigate differences in the specific immune response to sheep red blood cells (SRBC) of female common voles living in matriarchal groups. The applied test proved to be a useful tool for studying the effect of the social environment on the immune response in small mammals. The re...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00332-2

    authors: Heise SR,Van Acker A

    更新日期:2000-11-01 00:00:00

  • Properties of smooth pursuit adaptation induced by theta motion.

    abstract::Current study attempted to determine whether repeated smooth pursuit trials using theta motion, in which the directions of retinal image-motion and object-motion are opposed, yield pursuit adaptation. Adaptation trials consisted of 350 step-ramp trials using theta motion, and pre- and post-trials using first-order mot...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113245

    authors: Miyamoto T,Miura K,Kizuka T,Ono S

    更新日期:2021-02-01 00:00:00

  • Tail pinch-induced eating: is it the tail or the pinch?

    abstract::Mildly pinching the tail of the rat results in a set of consummatory behaviors including eating, chewing and licking. This phenomenon has been characterized as one which is not causally dependent on induction of pain. In the present study we report that pinching the scruff of the neck, the ears, or the rear paw of rat...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90154-8

    authors: Levine AS,Morley JE

    更新日期:1982-03-01 00:00:00

  • Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels.

    abstract::To determine the neuroendocrine pattern of response to excessive drinking induced by exposure of rats to an intermittent distribution of food (schedule-induced polydipsia, SIP), the present experiment investigated changes in plasma corticosterone, prolactin and catecholamines in chronically catheterized rats that had ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90187-4

    authors: Dantzer R,Terlouw C,Mormède P,Le Moal M

    更新日期:1988-01-01 00:00:00

  • Priming effects of activity-stress ulcer in rats.

    abstract::The activity-stress ulcer procedure consists of housing rats in running-wheel activity cages while at the same time, restricting their food intake to 1 hr per day. Male Wistar rats which had been habituated with ad lib feeding to the running-wheel cage environment for 3 days prior to the restricted feeding phase, deve...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90247-5

    authors: Tsuda A,Tanaka M,Nishikawa T,Iimori K,Hoaki Y,Ida Y,Kohno Y,Nagaski N

    更新日期:1982-10-01 00:00:00

  • Mechanisms of the anorexia of aging in the Brown Norway rat.

    abstract::Aging is associated with a loss of the ability to maintain homeostasis in response to physiologic and environmental disturbances. Age-related dysregulation of food intake and energy balance appears to be the result of impaired responsiveness of hypothalamic integrative circuitry to metabolic cues, which can lead to la...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2006.05.032

    authors: Wolden-Hanson T

    更新日期:2006-06-30 00:00:00

  • Validity of physiological biomarkers for maternal behavior in cows--a comparison of beef and dairy cattle.

    abstract::The objectives of the present study were to evaluate the suitability of potential biomarkers for maternal ability in cattle, and in addition to test the hypothesis that dairy cows have a less pronounced motherliness than beef cows. Therefore, maternal behavior of 20 Simmental beef-type (S) and 20 German Black Pied (da...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.10.030

    authors: Geburt K,Friedrich M,Piechotta M,Gauly M,König von Borstel U

    更新日期:2015-02-01 00:00:00

  • Benextramine, a putative neuropeptide Y receptor antagonist, attenuates the termination of receptivity.

    abstract::Sexual behavior in female rats is dependent on gonadal steroids. In ovariectomized rats, progesterone treatment typically exerts a biphasic effect on copulatory behavior induced by prior treatment with estradiol. Thus, there is an initial augmentation of the facilitative effect of estradiol occurring 4-10 h after prog...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90378-f

    authors: Clark JT

    更新日期:1992-11-01 00:00:00

  • Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse.

    abstract::The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive-compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has been linked to altered redox status and since increased dopamine signalling can promote stereoty...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.03.008

    authors: Güldenpfennig M,Wolmarans de W,du Preez JL,Stein DJ,Harvey BH

    更新日期:2011-06-01 00:00:00

  • Antidepressant effect of ingested nicotine in female rats of Flinders resistant and sensitive lines.

    abstract::Both major depression and depressive symptoms are associated with a high rate of nicotine dependence, and a history of major depression has an adverse impact on smoking cessation. The main objective of this study was to investigate whether continuous ingestion of nicotine affects indices of depressive behavior in the ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(99)00091-8

    authors: Djurić VJ,Dunn E,Overstreet DH,Dragomir A,Steiner M

    更新日期:1999-10-01 00:00:00

  • Responses to conspecifics' urine by the degu (Octodon degus).

    abstract::In nature the degu has been observed to deposit and to investigate scents. This study employed a captive group of these animals to investigate their responses to conspecific urinary marks in a neutral arena. Both sex classes served as subjects. They were presented with urine obtained from males, from females and a sal...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90027-7

    authors: Fischer RB,Meunier GF

    更新日期:1985-06-01 00:00:00

  • Protection against radiation-induced conditioned taste aversion by Centella asiatica.

    abstract::Radiations are known to cause behavioural perturbations like conditioned taste aversion (CTA), performance decrement, learning, etc., even at very low doses. The manifestation of radiation-induced behavioural degradation has not been understood well and requires further studies. Therefore, the effects of low-dose whol...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00434-6

    authors: Shobi V,Goel HC

    更新日期:2001-05-01 00:00:00

  • Water-deprivation prevents morphine-, but not LiCl-induced, suppression of sucrose intake.

    abstract::Intake of a saccharin-conditioned stimulus (CS) can be suppressed following pairing with an aversive agent such as lithium chloride (LiCl) or x-rays (referred to as a conditioned taste aversion or CTA), a highly rewarding sucrose solution (referred to as an anticipatory contrast effect), or a drug of abuse such as mor...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(99)00080-3

    authors: Grigson PS,Lyuboslavsky PN,Tanase D,Wheeler RA

    更新日期:1999-08-01 00:00:00

  • Naloxone influences retention behaviour depending on the degree of novelty inherent to the training situation.

    abstract::The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90394-4

    authors: Del Cerro S,Borrell J

    更新日期:1985-11-01 00:00:00

  • Dietary aspartame with protein on plasma and brain amino acids, brain monoamines and behavior in rats.

    abstract::Aspartame (APM; L-aspartyl-L-phenylalanine methyl ester), was investigated for its ability to alter levels of the large neutral amino acids and monoamines in overnight fasted rats allowed to consume meals with or without protein for two hours. Additionally, the possible long term behavioral consequences of APM in 25% ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90366-5

    authors: Torii K,Mimura T,Takasaki Y,Ichimura M

    更新日期:1986-01-01 00:00:00

  • Consuming aspartame with and without taste: differential effects on appetite and food intake of young adult males.

    abstract::Despite some reports that aspartame (APM)-sweetened beverages may increase subjective appetite, previously we demonstrated that drinking 280 ml of an APM-sweetened soft drink (170 mg APM) had no effect on appetite, and 560 ml of the same soft drink (340 mg APM) reduced appetite. The present study examined this appetit...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0031-9384(93)90139-7

    authors: Black RM,Leiter LA,Anderson GH

    更新日期:1993-03-01 00:00:00

  • The influence of a glucose drink on a demanding working memory task.

    abstract::A group of young adult females, who had or had not eaten breakfast, drank either a glucose drink or a placebo. Fasting was associated with poorer performance on the Brown-Petersen task, a test of memory. A glucose drink improved the memory of those who had fasted, although it did not influence those who had eaten brea...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0031-9384(99)00040-2

    authors: Martin PY,Benton D

    更新日期:1999-08-01 00:00:00