Abstract:
:A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time. Mice were injected daily with pyrazole, an inhibitor of alcohol dehydrogenase. The animals self-administered ethanol by inhaling vapour containing a relatively constant concentration of ethanol. Self-administration was voluntary: the mice could move to a chamber without ethanol vapour. During the first six days of each experiment, the animals were prompted to select the ethanol chamber by darkening that chamber. Most mice continued to self-administer ethanol without any prompting for at least 3 days; thereafter, preference for ethanol waned. Self-administration led to measurable levels of ethanol in blood and to the development of withdrawal when infusion of vapour was stopped.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Rijk H,Crabbe JC,Rigter Hdoi
10.1016/0031-9384(82)90333-xsubject
Has Abstractpub_date
1982-11-01 00:00:00pages
833-9issue
5eissn
0031-9384issn
1873-507Xpii
0031-9384(82)90333-Xjournal_volume
29pub_type
杂志文章abstract::This study was designed to analyze if the electroencephalographic (EEG) activity of the medial prefrontal cortex (mPFC) and the ventral tegmental area (VTA) was modified throughout various reproductive stages of female rats exposed to pup-associated or non-associated odors. Simultaneous EEG recordings were obtained fr...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.09.013
更新日期:2005-01-17 00:00:00
abstract::Patients suffering from depression-associated cognitive impairments often recover incompletely after remission from the core symptoms of depression (lack of energy, depressed mood and anhedonia). This study aimed to set the basis for clinically relevant testing of cognitive impairments in a preclinical model of depres...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.11.010
更新日期:2018-02-01 00:00:00
abstract::For this series of experiments, we wanted to investigate issues related to stress and learning. First, we wanted to determine if unpredictable stress might foster generalized fear responses more than predictable stress. Second, we wanted to evaluate how repeated stress might influence a rat's ability to learn what con...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.05.017
更新日期:2019-09-01 00:00:00
abstract::Lactic acid in arterial blood, systolic and diastolic blood pressures, and heart rates of baboons were examined for three naive subjects, and for five experimental subjects during baseline conditions and during training to elevate diastolic blood pressure through operant conditioning methodology. Lactic acid and cardi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90235-9
更新日期:1982-10-01 00:00:00
abstract::Feeding difficulties due to their condition have been widely described for babies, children and adults with Down syndrome (DS). A previous study demonstrated that, compared with wearing a placebo appliance, wearing an occlusal appliance increased inter-arch dental contacts, improved the oral health status of adults wi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.03.034
更新日期:2015-06-01 00:00:00
abstract::Animals living in temperate regions prepare for harsh winter conditions by responding to environmental cues that signal resource availability (e.g., food, day length). Siberian hamsters (Phodopus sungorus) breed in long, summer-like days (LD, >14h light), i.e., photoperiods, and undergo robust gonadal regression and b...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.09.023
更新日期:2016-12-01 00:00:00
abstract::Female mice from independently bred lines previously selected over 50 generations for increased voluntary wheel-running behavior (S1, S2) resist high energy (HE) diet-induced obesity (DIO) at adulthood, even without actual access to running wheels, as opposed to randomly bred controls (CON). We investigated whether ad...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.02.003
更新日期:2016-04-01 00:00:00
abstract::Rabbit pups raised by mothers fed different diets during pregnancy and lactation show a clear preference for the diet of their mother at weaning. By supplementing does' lab chow diet with aromatic juniper berries, the present study aimed to investigate the relative importance of 1) fecal pellets deposited by the mothe...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90322-0
更新日期:1994-11-01 00:00:00
abstract::This study evaluated the utility of the compound nerve action potential (CAP) and spinal nociceptive withdrawal (R3) reflex in identifying and quantifying peripheral afferent activity evoked by sural nerve stimulation in humans. The results of this work demonstrate that currents less than or equal to that which elicit...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90374-o
更新日期:1993-06-01 00:00:00
abstract::The influence of metabolic status on food selection during refeeding after fasting was investigated in rats fasted for a long period of time and subsequently given the choice of eating fat, protein, and carbohydrate individually. Rats were fasted until either metabolic phase 2 (essentially using lipids) or metabolic p...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02231-7
更新日期:1996-06-01 00:00:00
abstract::Previous studies in human infants, rabbits, and rats have shown that states of sleep and wakefulness can be reliably identified from motility signals produced by respiration and body movement. Thoman has described a computer-scoring algorithm for automated scoring of behavioral states from motility signals in human in...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90110-2
更新日期:1993-08-01 00:00:00
abstract::Ovarian hormones have been shown to regulate liver lipid accumulation in rats. The present study was designed to evaluate liver lipid resorption in ovariectomized (Ovx) rats. Ovx and sham-operated (Sham) rats were submitted to a high-fat (HF; 43% kcal fat as energy) diet for 5 weeks and then either maintained on this ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.05.024
更新日期:2008-09-03 00:00:00
abstract::Twenty-one healthy volunteers took part in the study, the aim of which was to determine the influence of acute pain on skin impedance, skin temperature and heart rate. Acute pain was induced by cold exposure. Skin impedance, heart rate and facial skin temperature were recorded before, during and after the painful stim...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90064-b
更新日期:1990-01-01 00:00:00
abstract::Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. How to safely and effectively remove the toxic Aβ42 peptide through blood-brain barrier (BBB) is considered to be an effective method for the prevention and treatment of AD. The compounds whose molecule weight is less than 400 Da and th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.11.016
更新日期:2015-02-01 00:00:00
abstract::The food intakes of male and female rats (Harvard strain) adapted to cold (5 degrees C) starting at weaning were studied in the cold and during reacclimation to 25 degrees C. Following 24 hr food deprivation, the male rats regained the weight they had lost without making up for the food they had missed (increased food...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90377-8
更新日期:1982-07-01 00:00:00
abstract::Numerous studies conducted with human participants have shown that differences in chronotype, defined as individual patterns of early or late beginning of daily activity, have implications for many biobehavioral processes, such as cognitive performance, mood, impulsivity, academic achievement of college students, and ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.11.019
更新日期:2019-02-01 00:00:00
abstract::This study determined whether liking and relative reinforcing value (RRV) of physical activity were associated with time youth spend in moderate-to-vigorous physical activity (MVPA). Boys (n=21) and girls (n=15) age 8 to 12 years were measured for height, weight, aerobic fitness, liking and RRV of physical activity, a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.01.010
更新日期:2008-03-18 00:00:00
abstract::Total body electrical conductivity (TOBEC) predictions of overall body fat were compared to combined perirenal and epididymal fat pad weights. The latter are considered to be reasonable estimates of overall adiposity. TOBEC was used to measure the body composition of 40 male Long-Evans and two male Sprague-Dawley rats...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00216-r
更新日期:1995-02-01 00:00:00
abstract::Despite some reports that aspartame (APM)-sweetened beverages may increase subjective appetite, previously we demonstrated that drinking 280 ml of an APM-sweetened soft drink (170 mg APM) had no effect on appetite, and 560 ml of the same soft drink (340 mg APM) reduced appetite. The present study examined this appetit...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0031-9384(93)90139-7
更新日期:1993-03-01 00:00:00
abstract::Because most naturally occurring toxins taste bitter to humans, any mechanism that reduces the rate at which bitter substances are ingested and digested should be adaptive. Based on the recent discovery of T2R bitter taste receptors in the gastrointestinal tract of rodents, we asked whether intragastric (IG) infusion ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.11.029
更新日期:2008-03-18 00:00:00
abstract::Interleukin-1 (IL-1), a cytokine secreted by activated macrophages, inhibits sexual behavior in female but not male rats. The present study examined the effects of IL-1 on sexual attractiveness of the injected animal and on the sexual responses exhibited by its mating partner. In Experiment 1, a male rat was placed wi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00381-8
更新日期:1997-12-31 00:00:00
abstract::Parents' feeding practices have been associated with children's dietary quality and food acceptance, but previous studies have largely relied exclusively on questionnaires to assess both parent and child behavior. The current study explored the relationships between parents' reported and observed feeding practices and...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.03.001
更新日期:2017-07-01 00:00:00
abstract::Isatin is an endogenous indole present in mammalian tissues and fluids. This study was designed to test the effect of both acute stress (AS) and gender on isatin's levels in rat serum, heart and brain, using a HPLC-UV detection method. Basal brain isatin levels were higher in females than in males. AS resulted in incr...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2003.11.005
更新日期:2004-02-01 00:00:00
abstract::The pituitary-adrenal response of mother and infant squirrel monkeys was assessed under basal conditions and after 5, 10, or 20 min of separation followed by 30 min of reunion. All separation conditions produced equal increments of cortisol (approximately 50%) in both mothers and infants. These increments were lower t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90029-0
更新日期:1985-06-01 00:00:00
abstract::Consistent individual differences in animals' responses to different stressful situations may indicate the involvement of a single behavioural and neurological mechanism across these situations. Two replicate groups of sixteen food restricted pigs were subjected to a group feeding competition test where group members ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90535-v
更新日期:1991-09-01 00:00:00
abstract::The zebrafish has become increasingly utilized in behavioral neuroscience, psychopharmacology, and behavior genetics research. However, little attention has been paid to the potential effects of environmental conditions fish are exposed to before and during behavioral testing. One such important factor is temperature,...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113169
更新日期:2020-12-01 00:00:00
abstract::Caloric restriction in mice can trigger gorging behaviour, which is characterized by periods of excessive food ingestion in a short time. Animals that gorge are thought to have a reduced metabolism compared to those that nibble their food over a longer period and might therefore be more able to compensate for reduced ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.07.005
更新日期:2007-12-05 00:00:00
abstract::The present study investigated the role of the midbrain reticular formation (MRF) in the expression of opposing locomotor asymmetries elicited from the medial and lateral substantia nigra pars compacta (SNC). It was found that unilateral MRF lesions produced ipsiversive circling that was potentiated by amphetamine. La...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90406-8
更新日期:1985-11-01 00:00:00
abstract::Temperature is known to impact taste perception, but its reported effect on sweet taste perception in humans is inconsistent. Here, we assess whether thermal taste phenotype alters the temperature modulation of the brains' response to sweet samples and sweet taste perception. Participants (n = 24 balanced for thermal ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113266
更新日期:2021-03-01 00:00:00
abstract::Groups of intact male and female Wistar rats were exposed to a standard passive avoidance procedure. The intensity of the light bulb illuminating the platform during adaptation, pre- and post-shock trials was manipulated (5, 25 or 75 W). Entrance latencies during pre-shock trials were longer for males than for females...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90084-3
更新日期:1986-01-01 00:00:00