Abstract：
:The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimental animals were returned to their home cage and their own room, receiving no further cues from the resident. Other animals serving as controls were placed in a clean and empty cage for 1 h. Five-minute open field tests were performed on days 1, 2, 7, 14, and 28 after defeat, with independent groups of rats. Locomotion of the animals was recorded and analyzed with an automated video system. Social defeat resulted in a strong subsequent reduction in open field activity, which lasted till at least 7 days after the conflict. Differences in total travelled distance were no longer significant 2 weeks after the conflict. The latency for moving to the outer ring of the open field arena after the start of the test was still significantly longer 4 weeks after defeat. The stress-induced reduction in open field locomotion could be reversed by 12-h sleep deprivation during the resting phase, an intervention known to have antidepressant effects in humans. Possible relevance of the present findings with respect to human affective disorders is discussed.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Meerlo P,Overkamp GJ,Benning MA,Koolhaas JM,Van den Hoofdakker RHdoi
10.1016/0031-9384(95)02271-6subject
Has Abstractpub_date
1996-07-01 00:00:00pages
115-9issue
1eissn
0031-9384issn
1873-507Xpii
0031938495022716journal_volume
60pub_type
杂志文章abstract：:The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn o...
journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1997-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90374-x
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90285-n
更新日期：1993-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90099-x
更新日期：1985-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1991-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1989-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02088-8
更新日期：1996-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90083-r
更新日期：1993-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90027-8
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90047-6
更新日期：1982-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90205-t
更新日期：1993-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.03.010
更新日期：2016-05-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00424-1
更新日期：1998-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90514-o
更新日期：1991-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90170-2
更新日期：1985-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00455-3
更新日期：2001-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02044-6
更新日期：1995-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90333-x
更新日期：1977-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2012-08-20 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90201-c
更新日期：1992-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.11.013
更新日期：2010-03-03 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
abstract：:Mice selected for aggressiveness (long and short attack latency mice; LALs and SALs, respectively) constitute a useful tool in studying the neural background of aggressive behavior, especially so as the SAL strain shows violent forms of aggressiveness that appear abnormal in many respects. By using c-Fos staining as a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.03.030
更新日期：2006-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00077-8
更新日期：1998-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2011-07-25 00:00:00
abstract：:Naltrexone, a potent opioid antagonist, was given to preweaning rats in order to explore the influence of endogenous opioid systems on organogenesis. Sprague-Dawley rats were injected (SC) daily with either 1 or 50 mg/kg naltrexone to invoke a temporary or complete blockade, respectively, of opioid receptors; animals ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90041-1
更新日期：1985-04-01 00:00:00
abstract：:The present study compared the ability of sweet ageusic T1r3 knockout (KO) and Calhm1 KO mice to acquire preferences for a sucrose-paired flavor as well as for unflavored sucrose. The KO and wildtype (WT) mice were given 24-h one-bottle access to 8% sucrose containing one flavor CS+, e.g., grape) and to water containi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.12.003
更新日期：2014-03-14 00:00:00
