Abstract:
:The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p < 0.05) increase (double) the seconds spent in their least-preferred chamber following cocaine-chamber pairings. Subsequently, groups of rats underwent one of three treatments: 1) olfactory bulbectomy (BULBX), 2) sham surgery (SHAM), or 3) sham surgery plus intranasal zinc sulfate perfusion (ZnSO4). Zinc sulfate was used to produce a temporary loss of olfaction. In a separate behavioral measure of olfactory acuity, both BULBX and ZnSO4-treated rats performed at an equally deficient level, in contrast to SHAM-treated rats that were not rendered anosmic. A second conditioned place preference test revealed that the ZnSO4-perfused and SHAM groups did not differ from their original postcocaine preference measurements. In contrast, the BULBX group spent significantly fewer seconds in the cocaine-paired chamber. After a 14-day interval, a third preference test revealed that SHAM and ZnSO4-treated rats displayed an equivalent preference for the cocaine-paired chamber (at 2.7 times above baseline). Interestingly, the seconds spent in the cocaine-paired chamber by BULBX rats did not differ from their baseline (e.g., precocaine exposure). These results suggest that bulbectomy disrupts the expression of cocaine-induced place preference. Interpretations of data from BULBX rats involving the production of an anhedonic condition and the relevance of olfactory bulbectomy as an animal model of anhedonic depression are discussed.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Calcagnetti DJ,Quatrella LA,Schechter MDdoi
10.1016/0031-9384(95)02119-1subject
Has Abstractpub_date
1996-04-01 00:00:00pages
597-604issue
4-5eissn
0031-9384issn
1873-507Xpii
0031-9384(95)02119-1journal_volume
59pub_type
杂志文章abstract:BACKGROUND:Studies evaluating the efficacy of anti-inflammatory treatment strategies for major depressive disorder (MDD) commonly include participants who do not demonstrate elevated concentrations of baseline inflammatory mediators, or simply fail to assess baseline inflammation. This may result in an underestimation ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.05.006
更新日期:2019-08-01 00:00:00
abstract::Bariatric surgery is an effective treatment for obesity that involves both peripheral and central mechanisms. To elucidate central pathways by which oral and visceral signals are influenced by high-fat diet (HFD) and Roux-en-Y gastric bypass (RYGB) surgery, we recorded from neurons in the caudal visceral nucleus of th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.07.025
更新日期:2015-12-01 00:00:00
abstract::This is the first experimental study directed at differentiating between physiological or sensory accounts of the satiation of nondrug cravings, using chocolate craving, the most common craving in North America. At the onset of craving, chocolate cravers consumed a chocolate bar, the caloric equivalent in "white choco...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0031-9384(94)90283-6
更新日期:1994-09-01 00:00:00
abstract::Male rats, fitted with indwelling gastric fistulas, were tested with either a closed fistula (normal drinking) or an open fistula (sham drinking) following either intracellular dehydration (with NaCl), extracellular dehydration (with PEG), or the combination of the two stimuli. In normal drinking tests, the combined s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90068-f
更新日期:1990-04-01 00:00:00
abstract::Previous studies have shown that extensive damage to the medial prefrontal cortex (mPFC) of rats causes reversal learning deficits. The mPFC of rats, however, consists of several subareas that are different from each other in both cytoarchitecture and neural connectivity, suggesting a functional dissociation among the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00216-9
更新日期:1998-11-15 00:00:00
abstract::Acquisition and reversal of a memory task dependent on hippocampal integrity were assessed in rats following chronic corticosterone treatment. Young adult male rats were injected daily with corticosterone (10 mg/kg, SC) for 8 weeks. Memory was assessed during the last week of treatment with an elevated platform maze. ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02172-8
更新日期:1996-06-01 00:00:00
abstract::Sugar-sweetened beverage (SSB) taxation has emerged as a priority policy for promoting health and funding investments in communities most affected by diet-related disease. There are now 8 U.S. jurisdictions and over 40 countries that have implemented SSB taxes. Evaluations show that these policies reduce SSB consumpti...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113105
更新日期:2020-10-15 00:00:00
abstract::Two-week-old chicks were trained in a simultaneous color discrimination learning task using food reinforcement. They had to discriminate between two discs of a different color whose right-left position was alternated at random. Results showed that chicks made more errors when the nonreinforced color was placed on the ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90297-7
更新日期:1989-04-01 00:00:00
abstract::The chronically elevated heat production of lactating Norway rats makes them vulnerable to acute hyperthermia during pup contact and thereby limits the duration of such interactions. High lactational levels of progesterone and corticosterone may act in concert to increase maternal heat load. Specifically, progesterone...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90094-6
更新日期:1986-01-01 00:00:00
abstract::In Experiment 1, an SC injection of 14 micrograms CRH greatly suppressed the vocalizing of isolated guinea pig pups 1 h later and produced highly elevated plasma cortisol levels. In Experiment 2, SC injection of 18 international units of ACTH produced similar cortisol elevations, but had a negligible effect on vocaliz...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90492-7
更新日期:1991-07-01 00:00:00
abstract::The ability to utilize oxygen has been shown to affect a wide variety of physiological factors often considered beneficial for survival. As the ability to learn can be seen as one of the core factors of survival in mammals, we studied whether selective breeding for endurance running, an indication of aerobic capacity,...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.01.011
更新日期:2012-05-15 00:00:00
abstract::Mixtures of compounds can often be tasted even when all of their components are too weak to be tasted separately. Such mixtures are said to be integrative. Integration was demonstrated by mixing compounds in concentrations proportional to their separate detection thresholds and then measuring the detection threshold o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00270-9
更新日期:1997-11-01 00:00:00
abstract::The neurotoxin capsaicin has been shown to selectively interfere with unmyelinated sensory fibers, as well as leading to depletions of substance P and other peptides. Meal pattern analysis was performed both before and after treatment with capsaicin in twelve adult male Sprague-Dawley rats. Capsaicin treatment only br...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90056-4
更新日期:1987-01-01 00:00:00
abstract::Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b.wt) for 8 weeks to female Wistar rats that were fed a high-cholesterol diet (HCD), to investigate the potential of M. alba leaves in attenuation of obesity, dyslipidemia, insulin resistance, and defici...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.12.010
更新日期:2019-03-15 00:00:00
abstract::The effects of castration on male spawning behavior, nestbuilding and fertility were measured in a five day spawning trial with an intact female. Spawning and fertility decreased one week following castration while nestbuilding was unaffected. Sham operated males showed normal spawning and fertility. Two weeks postope...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90281-5
更新日期:1977-09-01 00:00:00
abstract::In Experiment I, neurosensory responses from three limbic areas in the cat brain were recorded when cats of differing defensive temperamental traits were exposed to species characteristic threat. The cats investigated were more or less defensive in response to rats and conspecific threat howls. The behavioral disposit...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90264-o
更新日期:1991-03-01 00:00:00
abstract::Mesolimbic dopamine plays a critical role in food-related reward processing and learning. The literature focuses primarily on the nucleus accumbens as the key dopaminergic target in which enhanced dopamine signaling is associated with reward. Here, we demonstrate a novel neurobiological mechanism by which dopamine tra...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.02.026
更新日期:2014-09-01 00:00:00
abstract::Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-thre...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.11.016
更新日期:2012-04-12 00:00:00
abstract::Although elemental perception of odor mixtures allows us to perceive the component odor qualities, configural perception leads to the emergence of a new odor percept. The 6-odorant Red Cordial (RC) mixture is weak configurally perceived in newborn rabbits, meaning that pups respond to the odorants after conditioning t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.02.019
更新日期:2015-04-01 00:00:00
abstract::Oral cavity edge perception acuity relative to the fingertip has previously been evaluated by the utilization of cognitively-loaded, stereognostic methods. However, with the lack of connection of the tongue to the visual association cortex, there is concern the superior acuity of the fingertip may be attributable to t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113035
更新日期:2020-10-01 00:00:00
abstract::We evaluated how two diets with different lipid levels (4% vs. 10%) influenced nutrient expenditure in juvenile walleye Stizostedion vitreum subjected to starvation, prolonged swimming, and predator presence. We also determined how exercise and predator presence influenced stress indicators such as blood plasma cortis...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00124-0
更新日期:2003-09-01 00:00:00
abstract::Thermal tasting, an important type of individual variation in orosensation, is a phenomenon by which some individuals perceive thermally-induced taste sensations simply by having the tip of their tongue warmed or cooled. These individuals, known as thermal tasters, report a variety of thermally-elicited tastes (typica...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113160
更新日期:2020-12-01 00:00:00
abstract::Three experiments investigated the endogenous and exogenous controls of ring dove pecking. Experiment 1 confirmed that deprivation modulates adult pecking although nondeprived subjects peak at high levels. Experiment 2 determined that the level of pecking in nondeprived birds is modulated by exogenous cues such as the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90334-c
更新日期:1993-12-01 00:00:00
abstract::Lean, preweanling Zucker rat pups increase neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus in response to a 24-h deprivation of food, water, and maternal interaction as early as postnatal day 2 (P2). In this study, we examined if replacing nutritive or tactile aspects of maternal behavior to depriv...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(02)00644-3
更新日期:2002-03-01 00:00:00
abstract::Monoamines and their metabolites levels were simultaneously measured by high-performance liquid chromatography in brain regions of lean and fatty Zucker rats when fed ad lib and deprived of food for 72 hr to evaluate each monoamine metabolism. Metabolite/monoamine ratios were shown for brevity to represent its metabol...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90311-3
更新日期:1988-01-01 00:00:00
abstract::Administration of the opioid agonist, morphine (1 and 10 mg X kg-1), resulted in significant, dose-dependent increases in the ingestive responses of food-deprived slugs, Limax maximus, and in the initiation of feeding in satiated animals. These effects could be blocked by the opiate antagonist, naloxone (1 mg kg-1), w...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90045-3
更新日期:1984-11-01 00:00:00
abstract::The effects of chronic social stress on behavioral sensitization to cocaine were investigated in the Syrian hamster. Adolescent animals received either 15 mg/kg i.p. of cocaine or saline twice per day for 7 consecutive days. Two weeks following the last injection (young adulthood), they were given a challenge dose of ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(02)00727-8
更新日期:2002-08-01 00:00:00
abstract::Prior studies have demonstrated the utility of conditioned place preference procedures for examining the motivational or rewarding properties of behavior. The purpose of this experiment was to assess whether female Syrian hamsters would show evidence of conditioned place preference for aggression or sexual behaviors. ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90352-2
更新日期:1994-11-01 00:00:00
abstract::This paper describes a "stretching response" which occurs in some female laboratory rats during the course of mating. It is most obviously characterized by an indentation of the abdominal wall and tonic limb and pelvic movements, which occur in irregularly spaced pulses of variable duration. The response was not seen ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(80)90044-x
更新日期:1980-06-01 00:00:00
abstract::Dystonia musculorum (dt) mutant mice, characterized by degeneration of spinocerebellar fibers, were evaluated in a visible platform swim test. It was found that dt mutants were slower to reach the platform than normal mice. However, the number of quadrants traversed was not higher in dt mutants. It is concluded that s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90052-h
更新日期:1993-07-01 00:00:00