Plasma corticosterone levels as an index of the strength of illness induced taste aversions.

Abstract:

:Data are presented which demonstrate the task generality of pituitary-adrenal changes that accompany avoidance conditioning. In two experiments a conditioned aversion to milk was established by pairing it with lithium chloride (LiCl). In Experiment 1 conditioned pituitary-adrenal activation occurred when, in a conflict situation, animals reexperienced milk that had earlier been paired with LiCl. The relationship between the strength of aversion and corticosterone levels was such that animals showing the greatest avoidance showed the largest elevations in plasma corticosterone. In Experiment 2 this behavior/steroid relationship was manipulated. Dexamethasone (DEX) pretreatment on the day of conditioning was used to attenuate the conditioned aversion. Compared to saline (SAL) controls when reexposed to milk, DEX animals showed an attenuated aversion (i.e., drank more) and a smaller conditioned response (i.e., less adrenocortical activity). The reduction of conditioned elevation in corticosterone was not due to any residual effects of DEX at the time of testing (Experiment 3). Plasma levels of corticosterone represent an index for assessing the strength of illness induced conditioned taste aversions.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Smotherman WP,Hennessy JW,Levine S

doi

10.1016/0031-9384(76)90006-8

subject

Has Abstract

pub_date

1976-12-01 00:00:00

pages

903-8

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(76)90006-8

journal_volume

17

pub_type

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