Abstract:
:In Experiment 1, an SC injection of 14 micrograms CRH greatly suppressed the vocalizing of isolated guinea pig pups 1 h later and produced highly elevated plasma cortisol levels. In Experiment 2, SC injection of 18 international units of ACTH produced similar cortisol elevations, but had a negligible effect on vocalizations. In Experiment 3, the minimum effective dose of CRH for suppressing vocalizations was found to be about 7 micrograms. This dose also suppressed locomotor activity and produced cortisol elevations that were as great as those produced by the 14 micrograms dose. In Experiment 4, suppression of vocalizations by CRH was not reversed by 1 or 5 mg/kg body weight of naloxone. Rectal temperature was unaffected by CRH or naloxone. Thus, peripheral administration of CRH has a suppressive effect on the vocalizations of isolated guinea pig pups. The effect is accompanied by a reduction in locomotor activity and does not appear to be mediated by ACTH, cortisol, beta-endorphin, or an altered body temperature response to the isolation procedure. These results are consistent with the hypothesis that increased secretion of CRH contributes to the waning of the vocalizations of guinea pig pups during prolonged isolation.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Hennessy MB,Becker LA,O'Neil DRdoi
10.1016/0031-9384(91)90492-7subject
Has Abstractpub_date
1991-07-01 00:00:00pages
17-22issue
1eissn
0031-9384issn
1873-507Xpii
0031-9384(91)90492-7journal_volume
50pub_type
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journal_title:Physiology & behavior
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pub_type: 历史文章,杂志文章
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pub_type: 杂志文章
doi:10.1016/0031-9384(91)90202-y
更新日期:1991-05-01 00:00:00
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更新日期:1989-02-01 00:00:00
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更新日期:1993-11-01 00:00:00
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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更新日期:2013-07-02 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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