Lack of intersite GABA receptor subtype antagonist effects upon mu opioid receptor agonist-induced feeding elicited from either the ventral tegmental area or nucleus accumbens shell in rats.

Abstract:

:Pretreatment with the GABA(A) receptor antagonist, bicuculline or the GABA(B) receptor antagonist, saclofen, into the nucleus accumbens (Nacc) shell, respectively, potentiates and reduces feeding elicited by the mu opioid agonist, [D-Ala(2), Nme(4), Gly-ol(5)]-enkephalin (DAMGO), administered into the same site. DAMGO-induced feeding elicited from the ventral tegmental area (VTA) region is significantly reduced by pretreatment with saclofen into the same site indicating local GABA mediation of opioid-induced feeding in each site. Given the neuroanatomical and functional connections between the two sites, the present study evaluated the dose-dependent actions of bicuculline and saclofen pretreatment in one site upon DAMGO-induced feeding elicited from the second site. Pretreatment of either bicuculline (7.5-75 ng) or saclofen (1.5-10 microg) into the Nacc shell failed to alter the time course or magnitude of DAMGO-induced feeding elicited from the VTA region. DAMGO-induced feeding elicited from the Nacc shell was unaffected by VTA region pretreatment with either bicuculline (7.5-75 ng) or saclofen (1.5-5 microg). A higher (10 microg) saclofen dose prevented significant DAMGO-induced feeding after 1 and 4 h. Thus, although GABA receptor subtype antagonists are capable of differentially modulating DAMGO-induced feeding when both drugs are applied locally in either the VTA region or the Nacc shell, it appears that any effects between the VTA region and the Nacc shell in modulating DAMGO-induced feeding do not depend upon a GABAergic synapse in the other site.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Ackerman TF,Lamonte N,Bodnar RJ

doi

10.1016/s0031-9384(03)00087-8

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

191-8

issue

2

eissn

0031-9384

issn

1873-507X

pii

S0031938403000878

journal_volume

79

pub_type

杂志文章
  • Endoplasmic reticulum stress pathway mediates isoflurane-induced neuroapoptosis and cognitive impairments in aged rats.

    abstract::Postoperative cognitive dysfunction (POCD) is increasingly being recognized as an important clinical syndrome. Although it has been documented that volatile anesthetics induce neuronal apoptosis and cognitive deficits in several aged animal models, the underlying mechanisms are not well understood. Endoplasmic reticul...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.07.008

    authors: Ge HW,Hu WW,Ma LL,Kong FJ

    更新日期:2015-11-01 00:00:00

  • The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.

    abstract::Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this res...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.11.002

    authors: Bunney PE,Burroughs D,Hernandez C,LeSage MG

    更新日期:2016-02-01 00:00:00

  • Mineral content of the diet alters sucrose-induced obesity in rats.

    abstract::The effects of dietary mineral levels on caloric intake, nutrient choice, body weight, adipose tissue weight, interscapular brown adipose tissue (IBAT) weight, and thermogenic capacity, and plasma insulin and glucose levels were examined in adult male Sprague-Dawley rats. In Experiments 1 and 2, rats were fed a purifi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)00312-2

    authors: Bock BC,Kanarek RB,Aprille JR

    更新日期:1995-04-01 00:00:00

  • Food as a supplementary cue triggers seasonal changes in aggression, but not reproduction, in Siberian hamsters.

    abstract::Animals living in temperate regions prepare for harsh winter conditions by responding to environmental cues that signal resource availability (e.g., food, day length). Siberian hamsters (Phodopus sungorus) breed in long, summer-like days (LD, >14h light), i.e., photoperiods, and undergo robust gonadal regression and b...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.09.023

    authors: Bailey AM,Rendon NM,O'Malley KJ,Demas GE

    更新日期:2016-12-01 00:00:00

  • Role of AQP1 in inner ear in motion sickness.

    abstract::Inner ear is critical for the development of motion sickness (MS). The present work was designed to test the role of aquaporins (AQPs) in inner ear in MS. After repetitive stimulus of rotation, the MS symptom was steadily alleviated in mice. After repetitive stimulus of rotation, several AQPs mRNA levels including AQP...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.07.031

    authors: Huang YD,Xia SW,Dai P,Han DY

    更新日期:2011-10-24 00:00:00

  • The effects of glucocorticoids on feeding behavior in rats.

    abstract::Glucocorticoids have major effects on food intake, however, the underlying mechanisms are poorly understood. This article highlights data on the changes that occur when glucocorticoids are removed by adrenalectomy, and the effects of central and systemic administered glucocorticoids on feeding behavior in rats. Next, ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2006.01.028

    authors: la Fleur SE

    更新日期:2006-08-30 00:00:00

  • Timed food availability affects circadian behavior but not the neuropeptide Y expression in Indian weaverbirds exposed to atypical light environment.

    abstract::We tested the hypothesis whether daily food availability period would restore rhythmicity in individuals with disrupted circadian behavior with no effect on appetite regulation. Particularly, we investigated the effects of timed food availability on activity behavior, and Fos and neuropeptide Y expressions in Indian w...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.04.017

    authors: Singh D,Trivedi N,Malik S,Rani S,Kumar V

    更新日期:2016-07-01 00:00:00

  • Thirst interoception and its relationship to a Western-style diet.

    abstract::Less sensitive interoception for hunger and fullness has been observed in people who consume a diet rich in saturated fat and added sugar. In this study we examined whether healthy young people who routinely consume such diets, also demonstrate less sensitive thirst interoception. Participants, varying primarily in di...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.11.050

    authors: Brannigan M,Stevenson RJ,Francis H

    更新日期:2015-02-01 00:00:00

  • Control of the temporal location of schedule-induced attack in pigeons.

    abstract::Pigeons were exposed to complex fixed-ratio schedules to assess whether the temporal location of schedule-induced attack was controlled by the discriminative properties of food or by the aversive aftereffects of food withdrawal. When exposed to a multiple fixed-ratio 25 fixed-ratio N schedule in which either fixed-rat...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90193-3

    authors: Flory RK,Blosser SL

    更新日期:1985-03-01 00:00:00

  • Sex steroid dependence of carotenoid-based coloration in female zebra finches.

    abstract::Compared to male secondary sexual traits, the effect of testosterone (T) on female ornaments is understudied. In particular, it is unclear whether females experience different costs of T elevation than do males and how this affects the relationship between T and ornamentation in the two sexes. I experimentally and cor...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.04.003

    authors: McGraw KJ

    更新日期:2006-07-30 00:00:00

  • Interactions between body temperature and wheel running over the estrous cycle in rats.

    abstract::Female rats were housed in Wahmann wheels under a 12:12 light-dark (LD) photoperiod for 36 days and then were switched to LD 10:14 for 36-64 days. Running was 95-100% nocturnal. Overall amounts of running were higher in LD 12:12, but changes over the estrous cycle were similar. On the night of proestrus running increa...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90334-k

    authors: Kent S,Hurd M,Satinoff E

    更新日期:1991-06-01 00:00:00

  • Workshop on taste and smell in the elderly: an overview.

    abstract::The purpose of the workshop entitled Taste and Smell in the Elderly: Behavioral and Nutritional Consequences was 1) to review the current state of knowledge in the area of taste and smell, with emphasis on age-related changes, 2) to identify existing gaps in our knowledge, and 3) to develop future research strategies....

    journal_title:Physiology & behavior

    pub_type:

    doi:10.1016/s0031-9384(98)00261-3

    authors: Finkelstein JA,Schiffman SS

    更新日期:1999-04-01 00:00:00

  • Effect of a cage divider permitting social stimuli on stress and food intake in rats.

    abstract::The need to obtain data from individual laboratory animals has forced many researchers to singly-house small animals. This is costly to the researcher and isolation can adversely affect animal physiology and behavior which in turn may threaten the validity and generalization of experiment results to humans. We assesse...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.04.025

    authors: Boggiano MM,Cavigelli SA,Dorsey JR,Kelley CE,Ragan CM,Chandler-Laney PC

    更新日期:2008-09-03 00:00:00

  • Consumption of electrolytes and quinine by mouse strains with different blood pressures.

    abstract::Daily fluid intakes were measured using two-bottle tests in female mice of inbred strains with high (BPH/2), normal (BPN/3) or low (BPL/1) blood pressure. The mice were offered a choice between water and different concentrations of NaCl (37.5-600 mM), KCl (1-400 mM), CaCl2 (1-100 mM) and quinine hydrochloride (0.003-1...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00069-9

    authors: Bachmanov AA,Schlager G,Tordoff MG,Beauchamp GK

    更新日期:1998-06-01 00:00:00

  • Sex difference in blood pressure of spontaneously hypertensive rats influenced by perinatal NaCl exposure.

    abstract::Our prior study showed that the basal blood pressure level and pressor response to peripheral angiotensin II of adult Sprague-Dawley rats were enhanced by perinatal exposure to a high NaCl diet. The purpose of the present study was to assess further the relationship between NaCl-sensitivity of blood pressure and perin...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90164-w

    authors: Contreras RJ,Oparil S

    更新日期:1992-03-01 00:00:00

  • Acute and chronic stress influence blood pressure variability in mice.

    abstract::There is evidence that alterations in heart rate and blood pressure variability (BPV) are associated with cardiovascular disease. We used a mice model to investigate the effects of acute and chronic stress on blood pressure variability (BPV) and heat rate variability (HRV). Shaker stress was given acutely (5 min, 150 ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.08.004

    authors: Farah VM,Joaquim LF,Bernatova I,Morris M

    更新日期:2004-10-30 00:00:00

  • Dopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study.

    abstract::Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.01.003

    authors: Masini CV,Holmes PV,Freeman KG,Maki AC,Edwards GL

    更新日期:2004-03-01 00:00:00

  • Swimming activity in dystonia musculorum mutant mice.

    abstract::Dystonia musculorum (dt) mutant mice, characterized by degeneration of spinocerebellar fibers, were evaluated in a visible platform swim test. It was found that dt mutants were slower to reach the platform than normal mice. However, the number of quadrants traversed was not higher in dt mutants. It is concluded that s...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90052-h

    authors: Lalonde R,Joyal CC,Cote C

    更新日期:1993-07-01 00:00:00

  • An IBM-PC based data collection system for recording rodent sexual behavior and for general event recording.

    abstract::A microcomputer (IBM-PC) based data collection system for the acquisition and analysis of male rodent copulatory behavior and its reflexive components has been developed. This software features ease of data entry, flexibility across experimental protocols, and built-in tutorials. The program for the recording and anal...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90070-4

    authors: Holmes GM,Holmes DG,Sachs BD

    更新日期:1988-01-01 00:00:00

  • Prenatal exposure to nicotine attenuates stress-induced hyperthermia in 7- to 8-week-old rats upon exposure to a novel environment.

    abstract::Given that approximately 25% of women in the United States continue to smoke cigarettes during pregnancy, it is important to know if exposure to nicotine during development alters the physiological response of the adult to the "stressors" of everyday life. Our current experiments were carried out to determine if prena...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00609-6

    authors: Fewell JE,Eliason HL,Crisanti KC

    更新日期:2001-11-01 00:00:00

  • Daily supplementation of dietary protein improves the metabolic effects of GLP-1-based pharmacotherapy in lean and obese rats.

    abstract::Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from intestinal L-cells in response to food entering into the gastrointestinal tract. GLP-1-based pharmaceuticals improve blood glucose regulation and reduce feeding. Specific macronutrients, when ingested, may trigger GLP-1 secretion and enhance the effe...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.04.017

    authors: Mietlicki-Baase EG,Koch-Laskowski K,McGrath LE,Krawczyk J,Pham T,Lhamo R,Reiner DJ,Hayes MR

    更新日期:2017-08-01 00:00:00

  • Genetic deletions of NCAM and PSA impair circadian function in the mouse.

    abstract::The adult suprachiasmatic nuclei (SCN) express neural cell adhesion molecule (NCAM) that carries polysialic acid (PSA), a carbohydrate polymer which controls plastic cell-cell interactions in neural tissues. Expression of the three major isoforms of NCAM [180 (principal PSA carrier), 140, and 120 kDa) varies with deve...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00468-1

    authors: Shen H,Watanabe M,Tomasiewicz H,Glass JD

    更新日期:2001-05-01 00:00:00

  • Pharmacological and anatomical aspects of cholinergic activation of female sexual behavior.

    abstract::Forebrain infusion of cholinergic agonists activated the sexual response, lordosis, in ovariectomized female rats that had been primed with a low dose of estrogen. Carbachol, an agonist with both muscarinic and nicotinic properties, and oxotremorine, an agonist with a primarily muscarinic action, produced dose-related...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90296-8

    authors: Dohanich GP,Barr PJ,Witcher JA,Clemens LG

    更新日期:1984-06-01 00:00:00

  • Plasma levels of dihydrotestosterone in the cycling rat: implications for the regulation of lordosis behavior.

    abstract::Exogenously administered dihydrotestosterone (DHT) is a potent inhibitor of sexual behavior in ovariectomized, estrogen-primed rats and endogenous DHT has been implicated as an inhibitor of sexual behavior in cycling rats. To determine the temporal relationship between DHT levels and the expression of sexual behavior,...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90298-3

    authors: Dunlap KD,Sridaran R

    更新日期:1988-01-01 00:00:00

  • Brain insulin response to feeding in the rat is both macronutrient and area specific.

    abstract::Using microdialysis, we showed recently that hypothalamic immuno-reactive insulin (IRI) levels increased after a meal of chow and decreased in response to a fat meal. In the present study, we have compared extracellular hypothalamic and extrahypothalamic basal IRI levels and investigated the effect of meals composed e...

    journal_title:Physiology & behavior

    pub_type: 更正并重新发布的文章,杂志文章

    doi:10.1016/s0031-9384(99)00061-x

    authors: Gerozissis K,Rouch C,Nicolaidis S,Orosco M

    更新日期:1999-03-01 00:00:00

  • Dieting and pain sensitivity: a validation of clinical findings.

    abstract::To validate findings of a reduced pain sensitivity in anorexia and bulimia nervosa, the effects of dieting on somatosensation (especially pain sensitivity) were investigated in healthy young women. One group of subjects (n = 11) received a calorically reduced balanced diet for 21 days, while the other group (n = 14) c...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90557-5

    authors: Lautenbacher S,Barth K,Friess E,Strian F,Pirke KM,Krieg JC

    更新日期:1991-09-01 00:00:00

  • Naloxone-sensitive potentiation at granule cell synapses in the ventral dentate gyrus and stress ulcers.

    abstract::Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90121-h

    authors: Henke PG

    更新日期:1992-04-01 00:00:00

  • Ingestive/aversive response of rats to sweet stimuli. Influence of glucose, oil, and casein hydrolyzate gastric loads.

    abstract::Facial consummatory responses reflecting ingestive and aversive perceptions were studied and quantified in rats chronically implanted with gastric and oral catheters. A gustatory stimulus of 50 microliters of 0.6 mol.l-1 sucrose was injected into the mouth every 5 min during 90 min. At time zero, one of seven loads wa...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90215-n

    authors: Cabanac M,Lafrance L

    更新日期:1992-01-01 00:00:00

  • Neural coding of aversive and appetitive gustatory stimuli: interactions in the hamster brain stem.

    abstract::There is increasing evidence, both electrophysiological and behavioral, that bitter and sweet stimuli drive parallel pathways in the gustatory brainstem. Here we report two lines of investigation that suggest significant interactions among these parallel systems. First, responses recorded from single cells in the hams...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90365-4

    authors: Smith DV,Liu H,Vogt MB

    更新日期:1994-12-01 00:00:00

  • Effect of inhibition of gluconeogenesis on arginine-induced insulin secretion.

    abstract::It is well known that several amino acids, such as arginine, are potent stimuli for insulin and glucagon secretion from the pancreas. Recently, vagal arginine sensors, which modulate arginine-induced pancreatic hormone secretion, have been reported to exist in the liver. The present investigation was designed to evalu...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)00390-4

    authors: Trabelsi F,Hélie R,Bergeron R,Lavoie JM

    更新日期:1995-04-01 00:00:00