Abstract:
:Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The resulting BCR/c-abl hybrid gene is actively transcribed and is considered essential in the pathogenesis of this disease. Southern blot- and polymerase chain reaction (PCR)-based tests for the detection of this rearrangement have been introduced over the last decade. These molecular tests are useful adjuncts to cytogenetic analysis in CML and may provide useful clinical information in certain instances.
journal_name
Hum Patholjournal_title
Human pathologyauthors
McClure JS,Litz CEdoi
10.1016/0046-8177(94)90225-9subject
Has Abstractpub_date
1994-06-01 00:00:00pages
594-7issue
6eissn
0046-8177issn
1532-8392pii
0046-8177(94)90225-9journal_volume
25pub_type
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