Abstract：
:We have previously reported that the drs gene has the ability to suppress transformation by v-src and v-K-ras in the rat cell line F2808. We have also shown that the expression of drs mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that down-regulation of drs mRNA is correlated with the development of human cancers. To clarify the role of the drs gene in prostate carcinogenesis, we examined the expression of the drs gene in 3 normal prostate, 13 prostate carcinoma, 5 benign prostate hyperplasia (BPH), and 2 prostatic intraepithelial neoplasia (PIN) tissue specimens by in situ hybridization and in 3 prostate carcinoma cell lines (PC3, LNCaP, and DU145) and 2 BPH tissues by Northern blot analysis. Furthermore, the deletion, and rearrangement of the drs gene were analyzed by Southern blot analysis. The drs mRNA was significantly expressed in normal prostate and BPH tissues, whereas it was markedly down-regulated in prostate carcinoma tissues and prostate carcinoma cell lines. In 2 tissues from PIN, drs mRNA was weakly expressed. There were no differences between prostate carcinoma cell lines and BPH tissues in terms of their banding patterns of Southern blot analysis. These results indicate that down-regulation of drs mRNA is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kim CJ,Shimakage M,Kushima R,Mukaisho K,Shinka T,Okada Y,Inoue Hdoi
10.1016/s0046-8177(03)00240-5subject
Has Abstractpub_date
2003-07-01 00:00:00pages
654-7issue
7eissn
0046-8177issn
1532-8392pii
S0046817703002405journal_volume
34pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80312-3
更新日期：1984-12-01 00:00:00
abstract：:This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(78)80005-7
更新日期：1978-01-01 00:00:00
abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80143-3
更新日期：1982-01-01 00:00:00
abstract：:ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.009
更新日期：2008-06-01 00:00:00
abstract：:Ten cases of reactive follicular hyperplasia and 31 cases of B-cell non-Hodgkin's malignant lymphoma were studied using multiparameter flow cytometry. A bimodal distribution for HLA-DR expression, but not for surface immunoglobulin or B cell-specific antigens CD19 and CD20, was observed commonly in mixed cell type and...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(06)80042-0
更新日期：1990-12-01 00:00:00
abstract：:Collapsing glomerulopathy (CG), an aggressive variant of focal segmental glomerular sclerosis, is a renal disease with severe proteinuria and rapidly progressive renal failure. The pathogenesis of CG is unknown. It strongly resembles human immunodeficiency virus (HIV)-associated nephropathy, but the patients are HIV n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.124333
更新日期：2002-04-01 00:00:00
abstract：:The pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80012-6
更新日期：1987-03-01 00:00:00
abstract：:Fatty acids are implicated in tumorigenesis, but data are limited concerning endogenous fatty acid metabolism of tumor cells in adenomas and adenocarcinomas of the small intestine. The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in provid...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/s0046-8177(03)00431-3
更新日期：2003-10-01 00:00:00
abstract：:Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.011
更新日期：2015-02-01 00:00:00
abstract：:Deposits found intrauterine contraceptive devices (IUDs) were studied by scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray microanalysis. All seven devices, including five plastic and two copper IUDs, were coated with a crust containing cellular, acellular, and fibrillar material. The cellul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80160-x
更新日期：1985-07-01 00:00:00
abstract：:It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90038-1
更新日期：1995-02-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90226-0
更新日期：1995-07-01 00:00:00
abstract：:Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.02.019
更新日期：2010-11-01 00:00:00
abstract：:Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80169-7
更新日期：1987-04-01 00:00:00
abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.012
更新日期：2006-06-01 00:00:00
abstract：:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.10.008
更新日期：2015-01-01 00:00:00
abstract：:This study assessed squamous cell papillomas of the human esophagus for the presence of human papillomavirus (HPV) and correlated the results with histological features. Twenty-three lesions obtained by endoscopic biopsy from 17 patients were studied, first by in situ hybridization (ISH) for HPV types 6-11, 16-18, 18,...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90128-7
更新日期：1994-05-01 00:00:00
abstract：:The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90352-4
更新日期：1992-07-01 00:00:00
abstract：:The aim of this study was to systematically investigate clinicopathologic features of the recently described pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus (n = 43). Patient median age was 66 years (range, 51-90 years). The male-to-female ratio was 7.6. Grossly, pancreatic acinar-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.07.024
更新日期：2012-06-01 00:00:00
abstract：:Most ovarian sex cord-stromal tumors (SCSTs) can be categorized on the basis of conventional histology, but approximately 10% of cases are unclassified because they present indeterminate or overlapping morphologic features. Immunohistochemical and molecular studies of unclassified ovarian SCST are very limited, but re...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.07.028
更新日期：2013-12-01 00:00:00
abstract：:Metastatic cystic squamous cell carcinomas of the neck often harbor human papillomavirus 16 and, in turn, overexpress p16. P16 immunohistochemistry could be useful in the evaluation of patients who present with cystic squamous lesions of the neck, particularly when the distinction between a benign lymphoepithelial cys...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.09.006
更新日期：2010-04-01 00:00:00
abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:Lymphocytic colitis, previously termed "microscopic colitis", is a clinicopathologic syndrome of watery diarrhea, grossly normal colonoscopy, and mucosal inflammatory changes. Since lymphocytic colitis is a new, incompletely characterized entity, a histopathologic study was performed to compare lymphocytic colitis (n ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90198-6
更新日期：1989-01-01 00:00:00
abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.24997
更新日期：2001-06-01 00:00:00
abstract：:We have previously shown that necrotic tumors retain their immunoreactivity for a range of cytokeratin antibodies. Some thyroid tumors undergo extensive necrosis after fine-needle aspiration (FNA) procedures. We evaluated the sensitivity of antibodies on necrotic thyroid tumors by examining a series of thyroid tumors ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90071-0
更新日期：1999-11-01 00:00:00
abstract：:Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.05.008
更新日期：2004-09-01 00:00:00
abstract：:Cervical intraepithelial neoplasia (CIN) is historically viewed as a progressive biologic continuum leading to cervical cancer. However, it has been questioned whether CIN1 lesions ever progress. To this end, we evaluated the number of patients with a CIN3 and a previous CIN1 diagnosis. Subsequently, metachronous CIN1...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.014
更新日期：2014-02-01 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.07.018
更新日期：2018-12-01 00:00:00
abstract：:In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.008
更新日期：2008-08-01 00:00:00
