Abstract:
:Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We conducted a retrospective study to determine the prevalence of HPE among hospital autopsies over a 29-month period. Postmortem tissue was histologically evaluated for the presence, location(s) and extent of HPE. HPE findings were correlated with documented clinical and laboratory data and patient outcome. Of 136 hospital autopsies examined, 18 (13%) showed evidence of HPE involving the lungs (n = 18), heart (n = 1) or central nervous system (n = 1). Localized pulmonary HPE was seen in 12 patients (9%). Multifocal pulmonary HPE was found in 6 patients (4%) and was associated with clinical vasculitis (33%; P < .0001), suspected pulmonary ischemia (50%; P = .008), coagulopathy (67%; P = .002), and constitutional disease (83%; P = .01). Within affected lung, associated histopathologic changes included occlusive intravascular or perivascular inflammation (89%), intravascular fibrous response (56%), microthrombus formation (44%), vasculitis (28%), and/or pulmonary microinfarction (28%). Statistically significant differences in hospital days (P = .008) and number of vascular interventions (P = .01) were noted between affected and unaffected patients. We conclude that HPE is an underdiagnosed phenomenon with primary involvement of the lungs, where secondary vascular changes are common. Additional studies may be needed to clarify risks and to identify preventative strategies for this iatrogenic complication of catheterizations and "minimally invasive" endovascular techniques.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Mehta RI,Mehta RI,Choi JM,Mukherjee A,Castellani RJdoi
10.1016/j.humpath.2014.09.011subject
Has Abstractpub_date
2015-02-01 00:00:00pages
191-201issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00396-7journal_volume
46pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Except for post-transfusion hepatitis (PTH), the transmission of disease by blood transfusion appears to be very limited. There are only a few case reports documenting the transmission of malaria and other parasitic diseases, syphilis, or bacterial infections. The ability to eradicate PTH will depend on the developmen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80024-0
更新日期:1983-03-01 00:00:00
abstract::Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2017.05.010
更新日期:2017-09-01 00:00:00
abstract::Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.02.009
更新日期:2014-07-01 00:00:00
abstract::Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a supe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.32228
更新日期:2002-03-01 00:00:00
abstract::Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.02.007
更新日期:2009-08-01 00:00:00
abstract::Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.humpath.2017.03.023
更新日期:2017-06-01 00:00:00
abstract::Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9086
更新日期:2000-08-01 00:00:00
abstract::Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.015
更新日期:2016-11-01 00:00:00
abstract::The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129420
更新日期:2002-11-01 00:00:00
abstract::The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80279-3
更新日期:1985-10-01 00:00:00
abstract::We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.017
更新日期:2006-01-01 00:00:00
abstract::Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.033
更新日期:2017-10-01 00:00:00
abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90161-h
更新日期:1991-03-01 00:00:00
abstract::The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129416
更新日期:2002-11-01 00:00:00
abstract::The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80170-0
更新日期:1981-08-01 00:00:00
abstract::An unusual case of acute respiratory obstruction caused by multicentric granular cell tumors of the laryngotracheobronchial tree is presented. The patient also had granular cell tumors in the tongue, vulva, and chest wall. Multiplicity of the lesions in the left lung and recurrent episodes of intercurrent pulmonary in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80132-3
更新日期:1981-03-01 00:00:00
abstract::Autopsy rates continue to decline despite abundant evidence of the autopsy's value. Such an extraordinary contradiction requires that we look beyond issues of education to consider our basic moral and political commitments; to consider, in other words, the kind of society in which we live, and the kind of people we ar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90121-k
更新日期:1990-02-01 00:00:00
abstract::Several techniques for diagnosing adenocarcinoma of the lung are commonly available, but the frequency of their use and diagnostic sensitivity may vary. Twenty cases of primary lung adenocarcinoma obtained at surgery were studied by the following four routine techniques: light microscopy (LM) using hematoxylin-eosin (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80005-4
更新日期:1988-08-01 00:00:00
abstract::The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.10.016
更新日期:2015-02-01 00:00:00
abstract::Clinicopathological studies of 181 patients with liver cirrhosis undergoing autopsy in the pathology department of a municipal hospital between 1973 and 1976 are reported. The main etiological types were alcoholic (25.4 per cent), HBsAg positive (14.9 per cent), and cryptogenic cirrhosis (54.7 per cent). Four patients...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80082-2
更新日期:1981-09-01 00:00:00
abstract::Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.02.009
更新日期:2017-07-01 00:00:00
abstract::Twelve cases of bizarre parosteal osteochondromatous proliferation (BPOP), also known as Nora's lesion, are reported. Ten lesions were located in the small bones of the hands, and 2 were located in long bones (femur and proximal tibia). Patient age ranged from 12 to 63 years (average, 30.3 years). Radiography of the l...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.130103
更新日期:2002-12-01 00:00:00
abstract::Intraductal papillary neoplasm of the liver (IPNL) is a precursor lesion of intrahepatic cholangiocarcinoma (ICC) arising in hepatolithiasis. In this study, 98 foci of IPNL identified in 39 surgically resected hepatolithiatic livers were investigated for expression of p16INK4a, cyclin D1, p21WAF1/CIP1, p53, mouse doub...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.08.014
更新日期:2004-12-01 00:00:00
abstract::Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.11
更新日期:2003-02-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.128249
更新日期:2002-09-01 00:00:00
abstract::The DNA content of both fresh and formalin-fixed, paraffin-embedded tissues from 30 solid neoplasms was analyzed by flow cytometry. Cells from a single paraffin block of each tumor were disaggregated according to the method of Hedley et al. Cells were sampled from multiple sites of each fresh specimen. Fresh and depar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80521-5
更新日期:1988-03-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is known to play an important role in breast cancer invasion and metastatic progression. However, the pattern of expression of EMT markers in the progression from in situ to invasive breast carcinoma is not clear. To investigate this, we performed immunohistochemical analyses of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.07.003
更新日期:2013-11-01 00:00:00
abstract::Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(87)80413-6
更新日期:1987-12-01 00:00:00
abstract::Four human fetuses with the limb body wall malformation complex, also known as the amniotic band syndrome, were examined. Besides malformations of the body wall and the limb(s), anomalies of the internal organs were found in three fetuses, suggesting a disturbance of normal morphogenesis before the fifth week of devel...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90225-6
更新日期:1989-11-01 00:00:00