Abstract:
:Deposits found intrauterine contraceptive devices (IUDs) were studied by scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray microanalysis. All seven devices, including five plastic and two copper IUDs, were coated with a crust containing cellular, acellular, and fibrillar material. The cellular material was composed of erythrocytes, leukocytes, cells of epithelial origin, sperm, and bacteria. Some of the bacteria were filamentous, with acute-angle branching. The fibrillar material appeared to be fibrin. Most of the acellular material was amorphous; calcite was identified by x-ray diffraction, and x-ray microanalysis showed only calcium. Some of the acellular material, particularly that on the IUD side of the crust, was organized in spherulitic crystals and was identified as calcium phosphate by x-ray microanalysis. The crust was joined to the IUD surface by a layer of fibrillar and amorphous material. It is suggested that the initial event in the formation of calcific deposits on IUD surfaces is the deposition of an amorphous and fibrillar layer. Various types of cells present in the endometrial environment adhere to this layer and then calcify. Thus, the deposition of calcific material on the IUDs is a calcification phenomenon, not unlike the formation of plaque on teeth. Hum Pathol 16:732-738, 1985.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Khan SR,Wilkinson EJdoi
10.1016/s0046-8177(85)80160-xsubject
Has Abstractpub_date
1985-07-01 00:00:00pages
732-8issue
7eissn
0046-8177issn
1532-8392pii
S0046-8177(85)80160-Xjournal_volume
16pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.10.020
更新日期:2007-06-01 00:00:00
abstract::Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.033
更新日期:2017-10-01 00:00:00
abstract::No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.03.013
更新日期:2017-06-01 00:00:00
abstract::Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90078-4
更新日期:1991-04-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untransl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.01.001
更新日期:2017-06-01 00:00:00
abstract::Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90103-2
更新日期:1989-09-01 00:00:00
abstract::The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.05.025
更新日期:2011-02-01 00:00:00
abstract::The case of a patient in whom idiopathic thrombocytopenic purpura (ITP) was associated with diffuse splenic histiocytosis is described; the patient's subsequent sphingomyelinase level was at the lower limits of the normal range. The patient's splenic lecithin:sphingomyelin ratio was not significantly different from th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80192-1
更新日期:1985-11-01 00:00:00
abstract::To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30188
更新日期:2002-02-01 00:00:00
abstract::The drs gene was originally isolated from a rat primary embryo fibroblast cDNA library as a suppressor gene against v-src transformation. We have previously shown that expression of drs mRNA was markedly reduced in a variety of human cancer cell lines, including those of the colon, bladder, and ovary. Furthermore, int...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.125373
更新日期:2002-06-01 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.07.018
更新日期:2018-12-01 00:00:00
abstract::Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.03.004
更新日期:2008-10-01 00:00:00
abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.009
更新日期:2008-06-01 00:00:00
abstract::This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular ly...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.06.013
更新日期:2013-11-01 00:00:00
abstract::A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.05.002
更新日期:2009-11-01 00:00:00
abstract::Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been approved for the treatment of RCC. Combination therapy using PD-1/PD-L1 and ind...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.04.003
更新日期:2020-07-01 00:00:00
abstract::Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80022-7
更新日期:1983-03-01 00:00:00
abstract::Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80287-9
更新日期:1988-11-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.128249
更新日期:2002-09-01 00:00:00
abstract::Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.06.019
更新日期:2019-01-01 00:00:00
abstract::Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90065-5
更新日期:1994-10-01 00:00:00
abstract::We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90432-4
更新日期:1998-10-01 00:00:00
abstract::Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.05.016
更新日期:2008-01-01 00:00:00
abstract::Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90175-5
更新日期:1989-02-01 00:00:00
abstract::One hundred cases of invasive breast carcinoma were studied using the commercially available monoclonal antibody Anti-Human Tumor-Associated Glycoprotein-72 (MAb B72.3, Biomedical Technologies Inc, Stoughton, MA) prediluted at 8.5 micrograms/mL. Forty-three cases displayed positive reactivity with this antibody. Inten...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90238-k
更新日期:1991-06-01 00:00:00
abstract::The Mix1 homeobox-like (MIXL1) gene encodes a paired class homeobox transcription factor that is involved in embryogenesis. Previous studies have shown that the MIXL1 gene product is expressed in B- and T-cell progenitors of normal bone marrow and, in some cell lines derived from hematopoietic neoplasms. The status of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.020
更新日期:2007-03-01 00:00:00
abstract::The outcomes of patients with stage I non-small-cell lung cancer (NSCLC) vary greatly, with a 5-year survival rate of approximately 60%. This study evaluated a number of molecular markers that may aid in predicting prognosis in stage I NSCLC after surgical resection. Immunohistochemical (IHC) staining of p53, HER-2/ne...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30183
更新日期:2002-01-01 00:00:00
abstract::The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129416
更新日期:2002-11-01 00:00:00
abstract::Oncogenes, growth factors, cell surface receptors, and cell-cycle and apoptotic regulatory proteins have been implicated in the growth regulation and progression of Barrett's-associated neoplasia. Among these, insulin-like growth factor 1 receptor (IGF1-R) and c-Src are reported to be key regulators of mitogenesis and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/s0046-8177(03)00354-x
更新日期:2003-10-01 00:00:00