Abstract:
:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperitoneal teratoma measuring 18 x 11 x 8 cm in size. A hemorrhagic focus measuring 4 cm in diameter was present, which proved to be the focus of an endodermal sinus tumor histologically. The retroperitoneal mature teratoma observed in this case showed malignant germ-cell differentiation. The above case is thought to be extremely rare, but these findings also suggest the possibility of a mature teratoma presenting as a premalignant condition. The sequence of "mature teratoma--germ-cell malignancy" is thus considered to represent a new potential pattern of early phase of carcinogenesis in teratomas.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Ohno Y,Kanematsu Tdoi
10.1016/s0046-8177(98)90432-4subject
Has Abstractpub_date
1998-10-01 00:00:00pages
1167-9issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(98)90432-4journal_volume
29pub_type
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