Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation.

abstract：:We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD...

journal_title：Human pathology

authors： Zhang Y,Pillai G,Gatter K,Blázquez C,Turley H,Pezzella F,Watt SM

更新日期：2005-07-01 00:00:00

abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...

journal_title：Human pathology

authors： Lee MC,Kim GM,Woo YJ,Kim MK,Kim JH,Nam SC,Suh JJ,Chung WK,Lee JS,Kim HI,Choi HY,Kim SU

更新日期：2001-06-01 00:00:00

abstract：:Colonic adenocarcinomas are among the most common type of tumors. In this report, we present the morphologic, immunohistochemical, and microsatellite findings of 2 cases with a distinct invasive papillary component. Both tumors arose from polyps in middle-aged patients, followed an aggressive course, and showed a supe...

journal_title：Human pathology

authors： Palazzo JP,Edmonston TB,Chaille-Arnold LM,Burkholder S

更新日期：2002-03-01 00:00:00

abstract：:Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...

journal_title：Human pathology

authors： Lambros MB,Natrajan R,Reis-Filho JS

更新日期：2007-08-01 00:00:00

abstract：:Two episodes of severe, relapsing sensorimotor polyneuropathy closely paralleled the course of systemic illness in a patient with immunoblastic lymphadenopathy. A review of the literature shows three other cases, although none with documented pathologic changes in muscles and nerves. Based on the pathologic findings i...

journal_title：Human pathology

authors： Cytowic RE,Challa VR,Buss DH,Angelo JN

更新日期：1982-02-01 00:00:00

abstract：:Cancer cells show a higher rate of anaerobic respiration than normal cells. The exact mechanisms for this higher glycolysis rate in cancer cells remain to be elucidated. The results of recent studies have indicated that p53, the most commonly mutated tumor suppressor gene, may have important functions in the regulatio...

journal_title：Human pathology

authors： Won KY,Lim SJ,Kim GY,Kim YW,Han SA,Song JY,Lee DK

更新日期：2012-02-01 00:00:00

abstract：:Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated pro...

journal_title：Human pathology

authors： Jang S,Hong M,Shin MK,Kim BC,Shin HS,Yu E,Hong SM,Kim J,Chun SM,Kim TI,Choi KC,Ko YW,Kim JW

更新日期：2017-07-01 00:00:00

abstract：:This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...

journal_title：Human pathology

authors： Ono K,Oshiro M,Uemura K,Ota H,Matsushita Y,Ijima S,Iwase T,Uchida M,Katsuyama T

更新日期：1996-01-01 00:00:00

abstract：:Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...

journal_title：Human pathology

authors： Dickersin GR,Rosenberg AE

更新日期：1991-03-01 00:00:00

abstract：:The immunohistologic distribution of the basement membrane components, type IV collagen and laminin, was evaluated in 57 alcohol-fixed, paraffin-embedded tissue sections which demonstrated immunostaining patterns with antigen preservation similar to that of frozen tissue sections. Normal and hyperplastic squamous muco...

journal_title：Human pathology

authors： Sakr WA,Zarbo RJ,Jacobs JR,Crissman JD

更新日期：1987-10-01 00:00:00

abstract：:Decreases in true expenses in the hospital clinical laboratory consequent to reduced utilization were estimated from four models. Each category of direct expense was adjusted according to projections and confirmed to the extent possible by actual experience. No projections of reductions in indirect expenses were made....

journal_title：Human pathology

authors： Winkelman JW

更新日期：1984-06-01 00:00:00

abstract：:Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...

journal_title：Human pathology

authors： Harada K,Masuda S,Hirano M,Nakanuma Y

更新日期：2003-09-01 00:00:00

abstract：:Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis in several malignancies but never in renal cancer. We aim to analyze the...

journal_title：Human pathology

authors： López JI,Errarte P,Erramuzpe A,Guarch R,Cortés JM,Angulo JC,Pulido R,Irazusta J,Llarena R,Larrinaga G

更新日期：2016-08-01 00:00:00

abstract：:Bcl-2 and bcl-xL are proteins known to inhibit cell death (apoptosis). Expression of these proteins in gangliogliomas has not been extensively examined. This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas. Twenty-nine gangliogliomas in 17 males and 12 fe...

journal_title：Human pathology

authors： Prayson RA

更新日期：1999-06-01 00:00:00

abstract：:Several techniques for diagnosing adenocarcinoma of the lung are commonly available, but the frequency of their use and diagnostic sensitivity may vary. Twenty cases of primary lung adenocarcinoma obtained at surgery were studied by the following four routine techniques: light microscopy (LM) using hematoxylin-eosin (...

journal_title：Human pathology

authors： McGregor DH,Dixon AY,McGregor DK

更新日期：1988-08-01 00:00:00

abstract：:Although mast cell proliferation in the bone marrow frequently occurs in systemic mastocytosis and is often associated with radiographically detectable bone lesions, the pathologic correlates of the skeletal abnormalities are poorly characterized. We therefore examined three nondecalcified transiliac crest biopsy spec...

journal_title：Human pathology

authors： Fallon MD,Whyte MP,Teitelbaum SL

更新日期：1981-09-01 00:00:00

abstract：:Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...

journal_title：Human pathology

authors： Righi A,Mancini I,Gambarotti M,Picci P,Gamberi G,Marraccini C,Dei Tos AP,Simi L,Pinzani P,Franchi A

更新日期：2017-10-01 00:00:00

abstract：:Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...

journal_title：Human pathology

authors： Zheng Y,Lu X,Xu L,Chen Z,Li Q,Yuan J

更新日期：2017-11-01 00:00:00

abstract：:GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...

journal_title：Human pathology

authors： Gulbahce HE,Sweeney C,Surowiecka M,Knapp D,Varghese L,Blair CK

更新日期：2013-11-01 00:00:00

abstract：:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...

journal_title：Human pathology

authors： Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJ

更新日期：2003-04-01 00:00:00

abstract：:We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750...

journal_title：Human pathology

authors： Weissferdt A,Kalhor N,Bishop JA,Jang SJ,Ro J,Petersson F,Wu B,Langman G,Bancroft H,Bi Y,Meng Y,Medeiros F,Brunnstrom H,Spagnolo D,Chai SM,Laycock A,Wakely PE Jr,Elmberger G,Soares FA,Campos AH,Gumurdulu D,Alvara

更新日期：2018-03-01 00:00:00

abstract：:Plasmacytoid dendritic cells, which play a fundamental role in the innate immune response, are best known for their presence in hyaline-vascular Castleman disease and histiocytic necrotizing lymphadenitis. The relative number and distribution in many reactive entities as detected using more sensitive methods are uncer...

journal_title：Human pathology

authors： Rollins-Raval MA,Marafioti T,Swerdlow SH,Roth CG

更新日期：2013-06-01 00:00:00

abstract：:Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value ...

journal_title：Human pathology

authors： Li X,Xiao Y,Fan S,Xiao M,Wang X,Zhu X,Chen X,Li C,Zong G,Zhou G,Wan C

更新日期：2016-11-01 00:00:00

abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...

journal_title：Human pathology

authors： Berumen J,Unger ER,Casas L,Figueroa P

更新日期：1995-06-01 00:00:00

abstract：:Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...

journal_title：Human pathology

authors： Yokoi T,Mark EJ

更新日期：1991-07-01 00:00:00

abstract：:Thrombosis of large fetal vessels in the placenta leads to regions of downstream avascular villi (AV). Avascular villi have been associated with adverse outcomes in anecdotal reports, but no controlled study of their significance has been done. We prospectively gathered cases of extensive AV (n = 29) occurring over a ...

journal_title：Human pathology

authors： Redline RW,Pappin A

更新日期：1995-01-01 00:00:00

abstract：:We report three cases of follicular dendritic cell sarcoma (FDCS) showing a hitherto undescribed histological pattern consisting of nodular tumor growth associated with small B lymphocytes. FDCS tumor cells consistently showed large epithelioid features and were intermingled with small lymphocytes in the nodules in tw...

journal_title：Human pathology

authors： Lorenzi L,Lonardi S,Petrilli G,Tanda F,Bella M,Laurino L,Rossi G,Facchetti F

更新日期：2012-02-01 00:00:00

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...

journal_title：Human pathology

authors： Guérin M,Thariat J,Ouali M,Bouvier C,Decouvelaere AV,Cassagnau E,Aubert S,Lepreux S,Coindre JM,Valmary-Degano S,Larousserie F,Meilleroux J,Projetti F,Stock N,Galant C,Marie B,Peyrottes I,de Pinieux G,Gomez-Brouchet A

更新日期：2016-04-01 00:00:00

abstract：:As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor ...

journal_title：Human pathology

authors： Fletcher CD,Berman JJ,Corless C,Gorstein F,Lasota J,Longley BJ,Miettinen M,O'Leary TJ,Remotti H,Rubin BP,Shmookler B,Sobin LH,Weiss SW

更新日期：2002-05-01 00:00:00