Epithelial-to-mesenchymal transition-related transcription factors are up-regulated in ependymomas and correlate with a poor prognosis.

abstract：:The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...

journal_title：Human pathology

authors： Skaland I,van Diest PJ,Janssen EA,Gudlaugsson E,Baak JP

更新日期：2008-04-01 00:00:00

abstract：:Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...

journal_title：Human pathology

authors： Flucke U,Mentzel T,Verdijk MA,Slootweg PJ,Creytens DH,Suurmeijer AJ,Tops BB

更新日期：2012-05-01 00:00:00

abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...

journal_title：Human pathology

authors： Zhang M,Adeniran AJ,Vikram R,Tamboli P,Pettaway C,Bondaruk J,Liu J,Baggerly K,Czerniak B

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...

journal_title：Human pathology

authors： Nishimura S,Tsuda H,Kataoka F,Arao T,Nomura H,Chiyoda T,Susumu N,Nishio K,Aoki D

更新日期：2011-04-01 00:00:00

abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

journal_title：Human pathology

authors： Katz B,Tropé CG,Reich R,Davidson B

更新日期：2015-09-01 00:00:00

abstract：:We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in a...

journal_title：Human pathology

authors： Moran CA,Lindholm KE,Brunnström H,Langman G,Jang SJ,Spagnolo D,Chai SM,Laycock A,Falconieri G,Pizzolitto S,de Pellegrin A,Medeiros F,Edmunds L,Catarino A,Cunha F,Ro J,Pina-Oviedo S,Torrealba J,Coppola D,Petersson F

更新日期：2020-04-01 00:00:00

abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

journal_title：Human pathology

authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

更新日期：2010-03-01 00:00:00

abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...

journal_title：Human pathology

authors： di Sant'Agnese PA

更新日期：1992-03-01 00:00:00

abstract：:Metanephric stromal tumors (MSTs) are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors, along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of ...

journal_title：Human pathology

authors： Marsden L,Jennings LJ,Gadd S,Yu M,Perlman EJ,Cajaiba MM

更新日期：2017-02-01 00:00:00

abstract：:Metastatic cystic squamous cell carcinomas of the neck often harbor human papillomavirus 16 and, in turn, overexpress p16. P16 immunohistochemistry could be useful in the evaluation of patients who present with cystic squamous lesions of the neck, particularly when the distinction between a benign lymphoepithelial cys...

journal_title：Human pathology

authors： Cao D,Begum S,Ali SZ,Westra WH

更新日期：2010-04-01 00:00:00

abstract：:To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PC...

journal_title：Human pathology

authors： Poljak M,Cerar A,Seme K

更新日期：1998-03-01 00:00:00

abstract：:Thirty-nine mammographically detected, (M-detected) small invasive carcinomas of the breast (< or = 5 mm) were compared with 78 consecutive clinical cancers (> or = 10 mm) for a variety of morphological and biological markers of prognostic importance. There were more tubular carcinomas in the M-detected group (12.8% v...

journal_title：Human pathology

authors： Moezzi M,Melamed J,Vamvakas E,Inghirami G,Mitnick J,Quish A,Bose S,Zelman G,Roses D,Harris M,Feiner H

更新日期：1996-09-01 00:00:00

abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...

journal_title：Human pathology

authors： O'Connell JX,Fanburg JC,Rosenberg AE

更新日期：1995-07-01 00:00:00

abstract：:The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark. G9a is over-expressed in tumor cells and contributes to cancer aggressiveness. Biliary tract cancer (BTC) is a rare cancer with dismal prognosis due to a lack of effective ther...

journal_title：Human pathology

authors： Mayr C,Helm K,Jakab M,Ritter M,Shrestha R,Makaju R,Wagner A,Pichler M,Beyreis M,Staettner S,Jaeger T,Klieser E,Kiesslich T,Neureiter D

更新日期：2018-02-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...

journal_title：Human pathology

authors： O'Regan EM,Toner ME,Finn SP,Fan CY,Ring M,Hagmar B,Timon C,Smyth P,Cahill S,Flavin R,Sheils OM,O'Leary JJ

更新日期：2008-03-01 00:00:00

abstract：:T3 renal cell carcinoma (RCC) is a heterogeneous group of tumors that are substaged based on perirenal or sinus fat invasion, adrenal invasion, and renal vein invasion. To evaluate whether the extent of fat invasion (minimal versus extensive) and direct adrenal gland invasion, renal vein invasion with or without concu...

journal_title：Human pathology

authors： Jung SJ,Ro JY,Truong LD,Ayala AG,Shen SS

更新日期：2008-11-01 00:00:00

abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...

journal_title：Human pathology

authors： Wei Q,Zhou H,Zhong L,Shi L,Liu J,Yang Q,Zhao T

更新日期：2017-06-01 00:00:00

abstract：:Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...

journal_title：Human pathology

authors： Yang L,Chen Y,Cui T,Knösel T,Zhang Q,Geier C,Katenkamp D,Petersen I

更新日期：2012-09-01 00:00:00

abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...

journal_title：Human pathology

authors： Berumen J,Unger ER,Casas L,Figueroa P

更新日期：1995-06-01 00:00:00

abstract：:The case of a 65-year-old female patient with a pedunculated left atrial angiosarcoma is presented. Histologically, the tumor was composed of vascular spaces lined by atypical cells with similar cells in the solid portion of the tumor. Immunohistochemical stain for factor VIII-related antigen was positive in the cells...

journal_title：Human pathology

authors： Keohane ME,Lazzam C,Halperin JL,Strauchen JA,Ergin MA

更新日期：1989-06-01 00:00:00

abstract：:The benign epithelial neoplasm liver cell adenoma is rare, especially in childhood. We report 2 such cases, 1 of which was associated with Prader-Willi syndrome. Differential diagnosis of the liver cell adenomas on the basis of histopathologic findings proved difficult and was based on the absence of cellular and nucl...

journal_title：Human pathology

authors： Takayasu H,Motoi T,Kanamori Y,Kitano Y,Nakanishi H,Tange T,Nakagawara A,Hashizume K

更新日期：2002-08-01 00:00:00

abstract：:Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

journal_title：Human pathology

authors： Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

更新日期：2016-10-01 00:00:00

abstract：:Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates pr...

journal_title：Human pathology

authors： Simper NB,Jones CL,MacLennan GT,Montironi R,Williamson SR,Osunkoya AO,Wang M,Zhang S,Grignon DJ,Eble JN,Tran T,Wang L,Baldrige LA,Cheng L

更新日期：2015-06-01 00:00:00

abstract：:Pulmonary endodermal tumor resembling fetal lung describes an uncommon neoplasm of the lung which also has been referred to as pulmonary blastoma and adenocarcinoma of fetal lung type. We describe five cases which fall within a narrow band on the spectrum of pulmonary neoplasms with both epithelial and mesenchymal fea...

journal_title：Human pathology

authors： Nakatani Y,Dickersin GR,Mark EJ

更新日期：1990-11-01 00:00:00

abstract：:Galectins, a family of beta-galactoside-binding animal lectins, might be involved in tumor progression. In this study, the expression patterns of galectin-1 and -3 were examined immunohistochemically in intrahepatic cholangiocarcinoma (ICC), with emphasis on its development and progression as well as its histopatholog...

journal_title：Human pathology

authors： Shimonishi T,Miyazaki K,Kono N,Sabit H,Tuneyama K,Harada K,Hirabayashi J,Kasai K,Nakanuma Y

更新日期：2001-03-01 00:00:00

abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...

journal_title：Human pathology

authors： MacQuarrie E,Arnason T,Gruchy J,Yan S,Drucker A,Huang WY

更新日期：2012-08-01 00:00:00

abstract：:Epidermal growth factor receptor (EGF-r) expression and tumor cell proliferation rate have been proposed as potential prognostic parameters in renal cell carcinoma (RCC). In this study, immunohistochemical stains using antibodies to EGF-r and the cell proliferation marker Ki-67 (MIB-1) were used to study the relations...

journal_title：Human pathology

authors： Moch H,Sauter G,Buchholz N,Gasser TC,Bubendorf L,Waldman FM,Mihatsch MJ

更新日期：1997-11-01 00:00:00

abstract：:We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...

journal_title：Human pathology

authors： Oda Y,Okada Y,Katsuda S,Nakanishi I

更新日期：1994-10-01 00:00:00

abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...

journal_title：Human pathology

authors： Khettry U,Anand N,Gordon FD,Jenkins RL,Tahan SR,Loda M,Lewis WD

更新日期：2000-01-01 00:00:00

abstract：:Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...

journal_title：Human pathology

authors： Tabanelli V,Corsini C,Fiori S,Agostinelli C,Calleri A,Orecchioni S,Melle F,Motta G,Rotili A,Di Napoli A,Pileri SA

更新日期：2019-08-01 00:00:00