Abstract:
:Epidermal growth factor receptor (EGF-r) expression and tumor cell proliferation rate have been proposed as potential prognostic parameters in renal cell carcinoma (RCC). In this study, immunohistochemical stains using antibodies to EGF-r and the cell proliferation marker Ki-67 (MIB-1) were used to study the relationship between EGF-r expression, tumor cell proliferation, and prognosis in 50 non-papillary RCC extending beyond the renal capsule (pT3). A high Ki-67 labeling index (LI) was associated with poor patient prognosis (P < .05). Thirty-eight cases (76%) expressed strong cell membrane immunoreactivity for EGF-r. There was a tendency toward a shortened survival for EGF-r-positive tumors (P = .08). Tumor growth fraction (Ki-67 LI) was significantly higher in EGF-r-positive tumors than in EGF-r-negative tumors (P < .05), suggesting that rapid tumor proliferation might be responsible for the poor prognosis associated with EGF-r-positive RCC.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Moch H,Sauter G,Buchholz N,Gasser TC,Bubendorf L,Waldman FM,Mihatsch MJdoi
10.1016/s0046-8177(97)90198-2subject
Has Abstractpub_date
1997-11-01 00:00:00pages
1255-9issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(97)90198-2journal_volume
28pub_type
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