Abstract：
:Activating transcription factor 2 (ATF2) is a member of activator protein 1 superfamily, which can heterodimerize with other transcription factors regulating cell differentiation and survival. ATF2 assembles into a complex with the synovial sarcoma translocation, chromosome 18 (SS18)-synovial sarcoma, X breakpoint (SSX) fusion oncoprotein, and the transducin-like enhancer of split 1 (TLE1) corepressor, driving oncogenesis in synovial sarcoma. The fusion oncoproteins in many other translocation-associated sarcomas incorporate transcription factors from the ATF/cAMP response element binding or E26 families, which potentially form heterodimers with ATF2 to regulate transcription. ATF2 may therefore play an important role in the oncogenesis of many mesenchymal tumors, but as yet, little is known about its protein expression in patient specimens. Herein we perform immunohistochemical analyses using a validated specific antibody for ATF2 expression and intracellular localization on a cohort of 594 malignant and 207 benign mesenchymal tumors representing 47 diagnostic entities. Melanoma served as a positive control for nuclear and cytoplasmic staining. High nuclear ATF2 expression was mainly observed in translocation-associated and/or spindle cell sarcomas including synovial sarcoma, desmoplastic small round cell tumor, endometrial stromal sarcoma, gastrointestinal stromal tumor, malignant peripheral nerve sheath tumor, and solitary fibrous tumor. Cytoplasmic ATF2 expression was less frequently seen than nuclear expression in malignant mesenchymal tumors. Benign mesenchymal tumors mostly showed much lower nuclear and cytoplasmic ATF2 expression.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Endo M,Su L,Nielsen TOdoi
10.1016/j.humpath.2013.09.003subject
Has Abstractpub_date
2014-02-01 00:00:00pages
276-84issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(13)00385-7journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2009.06.017
更新日期：2010-03-01 00:00:00
abstract：:Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.08.004
更新日期：2015-12-01 00:00:00
abstract：:Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/j.humpath.2003.08.024
更新日期：2003-11-01 00:00:00
abstract：:Ultrastructural features of bilateral testicular biopsy materials, obtained from both tumor and nontumor areas of the testis of a 27-year-old man with congenital adrenal hyperplasia, revealed a number of pathologic changes. Germ cell hypoplasia and extratubular cellular hyperplasia were noticed in the nontumor portion...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80244-5
更新日期：1983-02-01 00:00:00
abstract：:Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90215-3
更新日期：1993-11-01 00:00:00
abstract：:Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.015
更新日期：2012-09-01 00:00:00
abstract：:After multiple fragmentation of neoplastic nuclei into "nucleotesimals," a recently discovered variety of amitosis, some fragments appear to be inflated to full nuclear size; other probably lyse, releasing nucleic acid, which may assist in the synthesis of new cytoplasm around newly formed nuclei. This observation may...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80006-3
更新日期：1982-07-01 00:00:00
abstract：:To investigate the relationship between the tissue distribution and the types of amyloid proteins, the detailed histopathologic features of the available liver in 284 cases of amyloidosis were examined. We classified hepatic amyloidosis into three types, namely, the vascular pattern, parenchymal pattern, and stromal p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90279-1
更新日期：1995-10-01 00:00:00
abstract：:Thromboangiitis obliterans (Buerger's disease) is an uncommon variety of occlusive peripheral vascular disease, occurring predominantly in young male tobacco smokers. The vascular lesion in the acute stage of thromboangiitis obliterans is distinctive and affects both the arteries and veins. Described here is an unusua...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80174-0
更新日期：1987-04-01 00:00:00
abstract：:Esophageal adenocarcinoma often presents at an advanced stage and has a dismal prognosis. Current prognostic markers have limited utility. ARID1A is implicated as a tumor suppressor gene in esophageal adenocarcinoma. Loss of ARID1A expression correlates with DNA mismatch repair (MMR) protein deficiency in other tumors...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.09.004
更新日期：2019-12-01 00:00:00
abstract：:We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But un...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.128062
更新日期：2002-10-01 00:00:00
abstract：:The cerebrum, cerebellum, and choroid plexuses from 16 patients with systemic amyloidosis, and the pituitary glands from 14 of these patients, were investigated histologically and immunohistochemically. Cerebrovascular amyloid (CVA) was found in the leptomeninges and cortices of six patients with systemic amyloidosis,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90102-0
更新日期：1989-09-01 00:00:00
abstract：:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.08.003
更新日期：2020-10-01 00:00:00
abstract：:The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin 5γ2, and SMAD4 and their relationship to survival were studied in different tumor areas, namely, tumor center and invasive fron...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.020
更新日期：2012-07-01 00:00:00
abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.023
更新日期：2015-12-01 00:00:00
abstract：:To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90202-g
更新日期：1990-04-01 00:00:00
abstract：:Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80375-1
更新日期：1987-11-01 00:00:00
abstract：:The presence of positive surgical margins is a negative prognostic indicator in patients undergoing prostatectomy for prostate cancer; whether the extent of the positive margins affects the clinical outcome with regards to prostate-specific antigen (PSA) recurrence remains uncertain. We evaluated the linear extent of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.006
更新日期：2007-08-01 00:00:00
abstract：:Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.022
更新日期：2012-09-01 00:00:00
abstract：:The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.022
更新日期：2007-09-01 00:00:00
abstract：:A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80237-7
更新日期：1981-01-01 00:00:00
abstract：:This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflamma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80241-5
更新日期：2000-03-01 00:00:00
abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.01.003
更新日期：2018-04-01 00:00:00
abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.03.005
更新日期：2006-08-01 00:00:00
abstract：:Virus-associated hemophagocytic syndrome (VAHS) is a nonneoplastic, generalized histiocytic proliferation with marked hemophagocytosis associated with a systemic viral infection. Histologic studies of lymph nodes usually show lymphoid depletion and histiocytic proliferation. In this report we describe the case of a pa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80225-3
更新日期：1987-10-01 00:00:00
abstract：:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta ce...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80154-0
更新日期：1988-10-01 00:00:00
abstract：:The striking differences in the histological features of gastric cancers in young and old adults have been thought to be related to differences in the biological behavior of these cancers. Recently, a new grading system (Goseki's classification) showed that the prognosis of the patient is particularly related to the m...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90059-9
更新日期：1997-09-01 00:00:00
abstract：:No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.013
更新日期：2017-06-01 00:00:00
abstract：:Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.002
更新日期：2014-06-01 00:00:00
abstract：:Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.31476
更新日期：2002-02-01 00:00:00
