Virus-associated hemophagocytic syndrome: identification of an immunoproliferative precursor lesion.

Abstract:

:Virus-associated hemophagocytic syndrome (VAHS) is a nonneoplastic, generalized histiocytic proliferation with marked hemophagocytosis associated with a systemic viral infection. Histologic studies of lymph nodes usually show lymphoid depletion and histiocytic proliferation. In this report we describe the case of a patient with Epstein-Barr virus-associated VAHS in which initial lymph node biopsy samples showed an immunoproliferative lesion that preceded the usual generalized histiocytic proliferation. This finding suggests that some cases of VAHS may have an immunoproliferative precursor lesion.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Daum GS,Sullivan JL,Ansell J,Mulder C,Woda BA

doi

10.1016/s0046-8177(87)80225-3

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

1071-4

issue

10

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(87)80225-3

journal_volume

18

pub_type

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