当前位置： SCI文献检索 > HUMAN PATHOLOGY期刊下所有文献 > Renal proliferative arteriopathies and associated glomerular changes: a light and electron microscopic study.

Renal proliferative arteriopathies and associated glomerular changes: a light and electron microscopic study.

Abstract：

:This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the diseases studied, the changes being related more to the severity and duration of injury than to the specific disease. Vascular narrowing was due mainly to intimal thickening, and by light microscopy the lesions were categorized as onionskin, mucinous, or fibrous with or without associated elastosis. Intimal erythrocyte extravasation, fibrinoid necrosis, and luminal thrombosis were also seen. Electron microscopy provided additional morphologic information: Myointimal cells were found to be the cellular component in each type of intimal thickening; it was possible to distinguish collagen from large intimal accumulations of basement membrane material; mucinous intimal material was characterized ultrastructurally; and fibrinoid necrosis was identified as a lesion inconstantly associated with cellular necrosis and consisting mainly of fibrinoid material and small deposits of fibrin. It seems likely that there is a common pathogenesis for intimal thickening in a variety of diseases and that this involves endothelial cell damage and increased permeability, leakage of serum and erythrocytes into the intima, and a healing reaction of the vessel wall was developing from migration of smooth muscle cells into the intima with subsequent myointimal cell proliferation and fibrogenesis. A common glomerular change in all diseases studied was a striking accumulation of electron lucent material between the endothelium and the lamina densa of the basement membrane. This lesion was interpreted as a manifestation of acute ischemia.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Sinclair RA,Antonovych TT,Mostofi FK

doi

10.1016/s0046-8177(76)80103-7

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

565-88

issue

5

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(76)80103-7

journal_volume

7

pub_type

杂志文章

相关文献

HUMAN PATHOLOGY文献大全
  • Relationship between tumor grade and computed architectural complexity in breast cancer specimens.

    abstract：:Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.10.001

    authors： Tambasco M,Magliocco AM

    更新日期：2008-05-01 00:00:00

  • The clinicopathological comparison among nodal cases of idiopathic multicentric Castleman disease with and without TAFRO syndrome.

    abstract：:Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype w...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2018.04.001

    authors： Kurose N,Futatsuya C,Mizutani KI,Kumagai M,Shioya A,Guo X,Aikawa A,Nakada S,Fujimoto S,Kawabata H,Masaki Y,Takai K,Aoki S,Kojima M,Nakamura S,Yamada S

    更新日期：2018-07-01 00:00:00

  • Microsatellite instability status does not predict total lymph node or negative lymph node retrieval in stage III colon cancer.

    abstract：:The relationship between higher total lymph node resection number in colorectal cancer resection specimens and improved overall survival is well known. Recent studies describe an association between a high rate of microsatellite instability and a high total lymph node count in colorectal cancer. Higher lymph node retr...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2011.10.002

    authors： MacQuarrie E,Arnason T,Gruchy J,Yan S,Drucker A,Huang WY

    更新日期：2012-08-01 00:00:00

  • Pseudogynecomastia due to neurofibromatosis--a light microscopic and ultrastructural study.

    abstract：:A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural stud...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(81)80180-3

    authors： Lipper S,Willson CF,Copeland KC

    更新日期：1981-08-01 00:00:00

  • Solitary fibrous tumors of the head and neck region revisited: a single-institution study of 20 cases and review of the literature.

    abstract：:A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humpath.2020.03.007

    authors： Baněčková M,Martínek P,Skálová A,Mezencev R,Hadravský L,Michal M,Švajdler M

    更新日期：2020-05-01 00:00:00

  • Intermediate lymphocytic lymphoma: an immunophenotypic study with comparison to small lymphocytic lymphoma and diffuse small cleaved cell lymphoma.

    abstract：:Sixteen cases of intermediate lymphocytic lymphoma (ILL), including eight cases with mantle zone architecture, were studied using cryostat sections, a biotin-avidin immunoperoxidase technique, and a large panel of monoclonal antibodies. The neoplastic cells invariably expressed IgM, most B lineage antigens (B1, TO15, ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(88)80203-x

    authors： Strickler JG,Medeiros LJ,Copenhaver CM,Weiss LM,Warnke RA

    更新日期：1988-05-01 00:00:00

  • The pathobiology of Schistosoma haematobium infection in humans.

    abstract：:Schistosoma haematobium infection is a common occurrence in Africa and the Middle East and is the world's leading cause of hematuria. Since more North Americans are venturing into endemic areas and more residents of endemic areas are seeking medical care in North America, pathologists must be able not only to diagnose...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(86)80456-7

    authors： Smith JH,Christie JD

    更新日期：1986-04-01 00:00:00

  • Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis.

    abstract：:Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2013.05.028

    authors： Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Imamura T,Morimoto A,Imashuku S,Gogusev J,Jaubert F,Takata K,Oka T,Yoshino T

    更新日期：2014-01-01 00:00:00

  • Morphologic and morphometric analyses of muscle in the neonatal myotonic dystrophy syndrome.

    abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(84)80312-3

    authors： Silver MM,Vilos GA,Silver MD,Shaheed WS,Turner KL

    更新日期：1984-12-01 00:00:00

  • ΔNp63 (p40) expression in prostatic adenocarcinoma with diffuse p63 positivity.

    abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2014.11.011

    authors： Uchida K,Ross H,Lotan T,Pignon JC,Signoretti S,Epstein JI,Illei PB

    更新日期：2015-03-01 00:00:00

  • Semiquantitative assessment of cytomorphologic features can predict mutation status of thyroid nodules with indeterminate cytologic diagnosis.

    abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2019.08.010

    authors： Shahi M,Bloechl SJ,Vogel RI,Shrestha R,Krigman HR,Evasovich M,Burmeister LA,Amin K

    更新日期：2019-11-01 00:00:00

  • Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer.

    abstract：:Tissue samples from patients with carcinoma of the prostate of various Gleason grades were examined for the frequency of apoptotic bodies. Apoptotic bodies were scored by morphometric methods using hematoxylin-eosin (HE)-stained sections from surgical specimens of prostate cancer. Non-neoplastic prostate tissue adjace...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(94)90249-6

    authors： Aihara M,Truong LD,Dunn JK,Wheeler TM,Scardino PT,Thompson TC

    更新日期：1994-08-01 00:00:00

  • Polypoid urothelial tumor with inverted growth pattern in the renal pelvis: morphologic and molecular characteristics of a unique diagnostic entity.

    abstract：:We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2016.07.030

    authors： Wobker SE,Zhong M,Epstein JI

    更新日期：2017-01-01 00:00:00

  • Destruction of canals of Hering in primary biliary cirrhosis.

    abstract：:The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.128060

    authors： Saxena R,Hytiroglou P,Thung SN,Theise ND

    更新日期：2002-10-01 00:00:00

  • Pure mucinous carcinomas of breast: morphologic features and prognostic correlates.

    abstract：:Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(86)80152-6

    authors： Clayton F

    更新日期：1986-01-01 00:00:00

  • MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1.

    abstract：:Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2017.09.006

    authors： Zheng Y,Lu X,Xu L,Chen Z,Li Q,Yuan J

    更新日期：2017-11-01 00:00:00

  • Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract.

    abstract：:The clinicopathologic features and immunohistochemical profiles of 14 cases of a distinctive mesenchymal tumor that arises in the superficial lamina propria of the cervix and vagina and is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including the cellular (pseudosarcomatous) variant...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2001.25588

    authors： Laskin WB,Fetsch JF,Tavassoli FA

    更新日期：2001-07-01 00:00:00

  • Overexpression of clusterin in human hepatocellular carcinoma.

    abstract：:Clusterin has been reported to play a significant role in tumorigenesis, and its overexpression occurs in various human malignancies. We examine the clusterin overexpression in human hepatocellular carcinoma (HCC) and verify its clinical usefulness as a candidate biomarker by clinicopathologic and survival analysis. W...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2004.07.021

    authors： Kang YK,Hong SW,Lee H,Kim WH

    更新日期：2004-11-01 00:00:00

  • Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma.

    abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.01.030

    authors： Wang J,Li G,Ma H,Bao Y,Wang X,Zhou H,Sheng Z,Sugimura H,Jin J,Zhou X

    更新日期：2007-11-01 00:00:00

  • Glomerular C3d as a novel prognostic marker for renal vasculitis.

    abstract：:Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series h...

    journal_title：Human pathology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.humpath.2016.05.015

    authors： Villacorta J,Diaz-Crespo F,Acevedo M,Guerrero C,Campos-Martin Y,García-Díaz E,Mollejo M,Fernandez-Juarez G

    更新日期：2016-10-01 00:00:00

  • Neuroendocrine differentiation in human prostatic carcinoma.

    abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/0046-8177(92)90110-o

    authors： di Sant'Agnese PA

    更新日期：1992-03-01 00:00:00

  • Digital histologic analysis reveals morphometric patterns of age-related involution in breast epithelium and stroma.

    abstract：:Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2015.09.031

    authors： Sandhu R,Chollet-Hinton L,Kirk EL,Midkiff B,Troester MA

    更新日期：2016-02-01 00:00:00

  • Uterine stromal neoplasms: a clinicopathologic and DNA flow cytometric correlation.

    abstract：:Twenty-five uterine stromal neoplasms (five stromal nodules and 12 low-grade and eight high-grade stromal sarcomas) were studied to determine the correlation between clinicopathologic features, flow cytometric tumor DNA content and proliferative fraction, and patient outcome. Fifteen of the 20 sarcomas (five of them h...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(91)90179-s

    authors： el-Naggar AK,Abdul-Karim FW,Silva EG,McLemore D,Garnsey L

    更新日期：1991-09-01 00:00:00

  • Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome.

    abstract：:p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2017.06.014

    authors： Liu Y,Alqatari M,Sultan K,Ye F,Gao D,Sigel K,Zhang D,Kalir T

    更新日期：2017-08-01 00:00:00

  • Granular transformation of Sertoli cells in testicular disorders.

    abstract：:In order to study the granular transformation of Sertoli cells the following testicular specimens were reviewed: 58 postmortem biopsies from 21 children and 37 young adult males with normal histologic pattern; 165 biopsies from prepubertal cryptorchid testes; 38 biopsies and 18 surgical specimens from postpubertal-cry...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(91)90034-m

    authors： Nistal M,Garcia-Rodeja E,Paniagua R

    更新日期：1991-02-01 00:00:00

  • Study of multiple human papillomavirus-related lesions of the lower female genital tract by in situ hybridization.

    abstract：:Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(89)90175-5

    authors： Pilotti S,Gupta J,Stefanon B,De Palo G,Shah KV,Rilke F

    更新日期：1989-02-01 00:00:00

  • Diagnosis of congenital syphilis from placental examination: comparison of histopathology, Steiner stain, and polymerase chain reaction for Treponema pallidum DNA.

    abstract：:Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(96)90110-0

    authors： Genest DR,Choi-Hong SR,Tate JE,Qureshi F,Jacques SM,Crum C

    更新日期：1996-04-01 00:00:00

  • Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies.

    abstract：:The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when em...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2020.07.011

    authors： Kanstrup Fiehn AM,Heiberg Engel PJ,Lanzarotto F,Goudkade D,Landolfi S,Munck LK,Villanacci V

    更新日期：2020-09-01 00:00:00

  • Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein.

    abstract：:Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2005.09.009

    authors： Ogawa T,Nagashima Y,Wada H,Akimoto K,Chiba Y,Nagatani T,Inayama Y,Yao M,Aoki I,Ikezawa Z

    更新日期：2005-12-01 00:00:00

  • Male breast cancer: a case of apocrine carcinoma with psammoma bodies.

    abstract：:A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(81)80178-5

    authors： Bryant J

    更新日期：1981-08-01 00:00:00