Abstract:
:Sixteen cases of intermediate lymphocytic lymphoma (ILL), including eight cases with mantle zone architecture, were studied using cryostat sections, a biotin-avidin immunoperoxidase technique, and a large panel of monoclonal antibodies. The neoplastic cells invariably expressed IgM, most B lineage antigens (B1, TO15, Leu-12, 6A4, 41H, BA-1, and LN-2), and Ia. IgD was expressed in 12 cases. Leu-1 and Leu-8 were weakly expressed by the tumor cells in 12 and 11 cases, respectively. The neoplastic cells did not express common acute lymphoblastic leukemia antigen (CALLA) or the T10 antigen in any case. Because ILL is difficult to differentiate from small lymphocytic lymphoma (SLL) and diffuse small cleaved cell lymphoma (DSCCL) on the basis of light microscopic criteria, the immunologic findings of ILL were compared to 31 cases of B cell SLL and 11 cases of B cell DSCCL previously studied in the laboratory to determine if immunologic findings might aid in the distinction. No absolute, and five statistically significant, differences were found; IgD in combination with IgM was seen more commonly in cases of ILL and DSCCL than in SLL (P less than .01), IgG was found more often in SLL than in ILL and DSCCL (P less than .05), Leu-8 was more commonly expressed in ILL and SLL than in DSCCL (P less than .05), T9 expression was less frequent in ILL as compared with SLL (P less than .05) and more proliferating cells were seen in ILL and DSCCL than in SLL (P less than .01). The investigators conclude that these three classes of lymphoma are remarkable much more for their immunologic similarities than for their differences and that immunologic studies are of limited usefulness in differentiating the three neoplasms. Their results also support the concept that these lymphomas are closely related to each other. In particular, DSCCL immunologically appears to be more closely related to SLL and ILL than to follicular small cleaved cell lymphoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Strickler JG,Medeiros LJ,Copenhaver CM,Weiss LM,Warnke RAdoi
10.1016/s0046-8177(88)80203-xsubject
Has Abstractpub_date
1988-05-01 00:00:00pages
550-4issue
5eissn
0046-8177issn
1532-8392pii
S0046-8177(88)80203-Xjournal_volume
19pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Among 448 malignant epithelial tumors of the gallbladder, 19 were classified as oat cell carcinomas. Seventeen cases occurred in elderly women. Eighteen of the patients had cholelithiasis. The neoplasms were highly lethal, metastasizing early and causing death shortly after diagnosis. All 19 patients died as a direct ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80288-9
更新日期:1984-07-01 00:00:00
abstract::Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90458-0
更新日期:1998-08-01 00:00:00
abstract::Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for rela...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.07.011
更新日期:2006-12-01 00:00:00
abstract::The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.07.002
更新日期:2017-09-01 00:00:00
abstract::A study of so-called gelatinous transformation of the bone marrow in 14 patients is presented. The condition is characterized by the presence of extracellular "gelatinous" material, fat atrophy, and associated focal marrow hypoplasia and is often mistaken as representing edema, necrosis, or amyloid. Histochemical stud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80051-3
更新日期:1978-11-01 00:00:00
abstract::Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.23523
更新日期:2001-04-01 00:00:00
abstract::Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.017
更新日期:2011-12-01 00:00:00
abstract::The national decline in hospital autopsy cases negatively impacts physician education and medical quality control to an unknown degree. The current non-medicolegal autopsy rate is less than 5% of hospital deaths. This study compares internal medicine and pathology resident physician perceptions of the autopsy, includi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.08.011
更新日期:2007-02-01 00:00:00
abstract::The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80077-5
更新日期:1984-05-01 00:00:00
abstract::Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.01.003
更新日期:2018-04-01 00:00:00
abstract::Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.7636
更新日期:2000-07-01 00:00:00
abstract::Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90232-r
更新日期:1992-02-01 00:00:00
abstract::Kidneys from 1864 necropsies performed in Brisbane, Australia, and from 397 necropsies performed in Christchurch, New Zealand, were examined macroscopically and microscopically. Three zonal and three focal patterns of renal medullary calcification were defined: (1) Outer medullary cortical calcification seen in hyperc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80057-3
更新日期:1976-07-01 00:00:00
abstract::The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129420
更新日期:2002-11-01 00:00:00
abstract::Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis in several malignancies but never in renal cancer. We aim to analyze the...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.03.009
更新日期:2016-08-01 00:00:00
abstract::Because infants rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80194-6
更新日期:1987-01-01 00:00:00
abstract::The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(96)90362-7
更新日期:1996-02-01 00:00:00
abstract::Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(89)90249-9
更新日期:1989-06-01 00:00:00
abstract::Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80031-8
更新日期:1983-03-01 00:00:00
abstract::Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.05.001
更新日期:2018-09-01 00:00:00
abstract::Intraductal carcinoma of the prostate (IDC-P) and high-grade prostatic intraepithelial neoplasia (HGPIN) are two distinct intraductal lesions; the former is usually associated with invasive carcinoma and has an aggressive course while the latter is considered a precancerous lesion. In addition, there are morphological...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.03.011
更新日期:2014-08-01 00:00:00
abstract::Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.031
更新日期:2016-02-01 00:00:00
abstract::This report describes the biopsy findings in four of 30 patients treated with cadaver osteochondral shell allografts for osteoarthritis in the knee. This study demonstrates that graft cartilage cells can survive in excess of 25 months, and that host bone can completely replace graft bone by creeping substitution. An i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80093-2
更新日期:1977-11-01 00:00:00
abstract::Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90104-0
更新日期:1997-02-01 00:00:00
abstract::Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.039
更新日期:2017-03-01 00:00:00
abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90161-h
更新日期:1991-03-01 00:00:00
abstract::The aims of this investigation were to compare quantitative with qualitative analysis of fluorescent in situ hybridization (FISH) centromere signals in interphase breast cancer cell nuclei and to evaluate the possible clinical utility of detecting numerical abnormalities of chromosomes 11 and 17 by FISH in the preoper...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90267-8
更新日期:1999-02-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::Tumor budding is an acknowledged prognostic marker in colorectal cancer. This study was conducted to investigate the morphology and prognostic significance of budding in rectal cancer after neoadjuvant radiotherapy. Surgical specimens from 96 consecutive patients who underwent neoadjuvant radiotherapy and curative res...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.07.026
更新日期:2012-07-01 00:00:00
abstract::Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.10.017
更新日期:2010-05-01 00:00:00