Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus.

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...

journal_title：Human pathology

authors： Yarom R,Carmy O,Robin GC,More R

更新日期：1981-07-01 00:00:00

abstract：:Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...

journal_title：Human pathology

authors： Kubo Y,Aishima S,Tanaka Y,Shindo K,Mizuuchi Y,Abe K,Shirabe K,Maehara Y,Honda H,Oda Y

更新日期：2014-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an angiogenic factor that plays important roles in tumor growth. Angiogenesis studies on VEGF deal with various types of malignant tumors, but very little is known about the role or significance of VEGF in human thyroid neo...

journal_title：Human pathology

authors： Katoh R,Miyagi E,Kawaoi A,Hemmi A,Komiyama A,Oyama T,Shibuya M

更新日期：1999-08-01 00:00:00

abstract：:Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...

journal_title：Human pathology

authors： Pilotti S,Gupta J,Stefanon B,De Palo G,Shah KV,Rilke F

更新日期：1989-02-01 00:00:00

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...

journal_title：Human pathology

authors： Yonezawa S,Sueyoshi K,Nomoto M,Kitamura H,Nagata K,Arimura Y,Tanaka S,Hollingsworth MA,Siddiki B,Kim YS,Sato E

更新日期：1997-03-01 00:00:00

abstract：:Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...

journal_title：Human pathology

authors： He D,Manzoni A,Florentin D,Fisher W,Ding Y,Lee M,Ayala G

更新日期：2016-06-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...

journal_title：Human pathology

authors： O'Regan EM,Toner ME,Finn SP,Fan CY,Ring M,Hagmar B,Timon C,Smyth P,Cahill S,Flavin R,Sheils OM,O'Leary JJ

更新日期：2008-03-01 00:00:00

abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...

journal_title：Human pathology

authors： di Sant'Agnese PA

更新日期：1992-03-01 00:00:00

abstract：:Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...

journal_title：Human pathology

authors： Diaz NM,McDivitt RW,Wick MR

更新日期：1991-12-01 00:00:00

abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...

journal_title：Human pathology

authors： Turner JR,Odze RD,Crum CP,Resnick MB

更新日期：1997-06-01 00:00:00

abstract：:Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited. This study was carried out to evaluate the frequency of BRAF V600E ...

journal_title：Human pathology

authors： Chatterjee D,Garg C,Singla N,Radotra BD

更新日期：2018-10-01 00:00:00

abstract：:The neuropathologic findings in the spinal cord were reviewed in 138 consecutive autopsies of patients with the acquired immunodeficiency syndrome. In all cases both the brain and spinal cord were examined by conventional histologic techniques, and in 63 cases immunohistochemistry was used to detect human immunodefici...

journal_title：Human pathology

authors： Hénin D,Smith TW,De Girolami U,Sughayer M,Hauw JJ

更新日期：1992-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many tumors, but data for primary neuroendocrine carcinoma (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prog...

journal_title：Human pathology

authors： Massi D,Franchi A,Ketabchi S,Paglierani M,Pimpinelli N,Santucci M

更新日期：2003-01-01 00:00:00

abstract：:The number of opportunistic infections in the central nervous system (CNS) has been steadily increasing because of a rising number of immunocompromised patients. A rare form of CNS infection can be caused by Chaetomium species, one of the largest genera of saprophytic ascomycetes. The CNS lesions in the present case w...

journal_title：Human pathology

authors： Thomas C,Mileusnic D,Carey RB,Kampert M,Anderson D

更新日期：1999-07-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Human pathology

authors： Genta RM

更新日期：2011-04-17 00:00:00

abstract：:Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...

journal_title：Human pathology

authors： Krencz I,Sebestyén A,Fábián K,Márk Á,Moldvay J,Khoor A,Kopper L,Pápay J

更新日期：2017-04-01 00:00:00

abstract：:The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...

journal_title：Human pathology

authors： Castellani C,Padalino M,China P,Fedrigo M,Frescura C,Milanesi O,Stellin G,Thiene G,Angelini A

更新日期：2010-11-01 00:00:00

abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...

journal_title：Human pathology

authors： Whitcomb E,Liu X,Xiao SY

更新日期：2014-02-01 00:00:00

abstract：:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta ce...

journal_title：Human pathology

authors： Ariel I,Kerem E,Schwartz-Arad D,Bartfeld E,Ron N,Pizov G,Zajicek G

更新日期：1988-10-01 00:00:00

abstract：:Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...

journal_title：Human pathology

authors： Gokden M,Mrak RE

更新日期：2009-08-01 00:00:00

abstract：:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...

journal_title：Human pathology

authors： Huszar M,Halkin H,Herczeg E,Bubis J,Geiger B

更新日期：1983-11-01 00:00:00

abstract：:We studied c-erbB-2, p53, and nm23 gene products in 112 primary breast carcinomas. Fifty patients were aged 35 years or younger, and 62 were aged 36 to 50. Clinicopathological criteria including clinical stage, hormone receptor status, histological types, histological grades, and lymph node status, were reviewed. Dise...

journal_title：Human pathology

authors： Bertheau P,Steinberg SM,Merino MJ

更新日期：1998-04-01 00:00:00

abstract：:Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...

journal_title：Human pathology

authors： Graeme-Cook F,Mark EJ

更新日期：1991-02-01 00:00:00

abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...

journal_title：Human pathology

authors： Boiocchi L,Hasserjian RP,Pozdnyakova O,Wong WJ,Lennerz JK,Le LP,Dias-Santagata D,Iafrate AJ,Hobbs GS,Nardi V

更新日期：2019-04-01 00:00:00

abstract：:A case of clear cell sarcoma of tendons and aponeuroses arising in the elbow of a young woman is reported. Local recurrence and lymph node metastases occurred despite radiation therapy, chemotherapy, and amputation of the right arm, and the patient died of the tumor approximately ten months after the initial diagnosis...

journal_title：Human pathology

authors： Azumi N,Turner RR

更新日期：1983-12-01 00:00:00

abstract：:Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

journal_title：Human pathology

authors： Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

更新日期：2016-10-01 00:00:00

abstract：:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...

journal_title：Human pathology

authors： Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJ

更新日期：2003-04-01 00:00:00

abstract：:Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....

journal_title：Human pathology

authors： Margraf LR,Paciga JE,Balis JU

更新日期：1990-04-01 00:00:00