MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients.

abstract：:A case of clear cell sarcoma of tendons and aponeuroses arising in the elbow of a young woman is reported. Local recurrence and lymph node metastases occurred despite radiation therapy, chemotherapy, and amputation of the right arm, and the patient died of the tumor approximately ten months after the initial diagnosis...

journal_title：Human pathology

authors： Azumi N,Turner RR

更新日期：1983-12-01 00:00:00

abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...

journal_title：Human pathology

authors： Walter O,Prasad M,Lu S,Quinlan RM,Edmiston KL,Khan A

更新日期：2009-11-01 00:00:00

abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...

journal_title：Human pathology

authors： Tsutsumi Y

更新日期：1989-09-01 00:00:00

abstract：:Histologic prognostic parameters in papillary renal cell carcinoma (PRCC) are unclear. The aims were to review the clinicopathological features of PRCC, including Fuhrman grade and International Society of Urological Pathology (ISUP) nucleolar grade, and to identify parameters that may be independent prognostic indica...

journal_title：Human pathology

authors： Cornejo KM,Dong F,Zhou AG,Wu CL,Young RH,Braaten K,Sadow PM,Nielsen GP,Oliva E

更新日期：2015-10-01 00:00:00

abstract：:The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...

journal_title：Human pathology

authors： Madri JA,Dise CA,LiVolsi VA,Merino MJ,Bibro MC

更新日期：1981-02-01 00:00:00

abstract：:In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not...

journal_title：Human pathology

authors： Ulbright TM,Clark SA,Einhorn LH

更新日期：1985-03-01 00:00:00

abstract：:Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...

journal_title：Human pathology

authors： Bae YK,Kim A,Kim MK,Choi JE,Kang SH,Lee SJ

更新日期：2013-10-01 00:00:00

abstract：:Disruptions of the p16-CDK4/cyclin D1-pRb pathway (RB pathway) and the p14ARF-MDM2-p53 pathway (p53 pathway) are important mechanisms in the development of human malignancies. In this study, we investigated RB and p53 pathways in 46 epithelial ovarian cancers (EOCs). In the RB pathway, 16 (34.8%) of 46 cases had p16 g...

journal_title：Human pathology

authors： Hashiguchi Y,Tsuda H,Yamamoto K,Inoue T,Ishiko O,Ogita S

更新日期：2001-09-01 00:00:00

abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...

journal_title：Human pathology

authors： Xing D,Banet N,Sharma R,Vang R,Ronnett BM,Illei PB

更新日期：2018-02-01 00:00:00

abstract：:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and d...

journal_title：Human pathology

authors： Kamel OW,Horoupian DS,Silverberg GD

更新日期：1989-12-01 00:00:00

abstract：:Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleate...

journal_title：Human pathology

authors： Kircher T

更新日期：1980-05-01 00:00:00

abstract：:A 48-year-old man with a history of recurrent urolithiasis and chronic renal failure underwent a nephrectomy for a renal mass. At surgery the mass proved to be a calculus impacted in a dilated calyx. Gross examination of the kidney revealed chalky white deposits in the deep medulla and papillary tips. Histologic exami...

journal_title：Human pathology

authors： Gelb AB,Fye KH,Tischfield JA,Sahota AS,Sparks JW,Hancock DC,Sibley RK

更新日期：1992-09-01 00:00:00

abstract：:Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...

journal_title：Human pathology

authors： Zirkin HJ,Levy J,Katchko L

更新日期：1996-09-01 00:00:00

abstract：:Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...

journal_title：Human pathology

authors： Veinot JP,Gattinger DA,Fliss H

更新日期：1997-04-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The ...

journal_title：Human pathology

authors： McClure JS,Litz CE

更新日期：1994-06-01 00:00:00

abstract：:Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...

journal_title：Human pathology

authors： Turner JR,Odze RD,Crum CP,Resnick MB

更新日期：1997-06-01 00:00:00

abstract：:Aquaporin 5 (AQP5) is an androgen-regulated member of a family of small hydrophobic integral transmembrane water channel proteins regulating cellular water homeostasis and growth signaling. To evaluate its clinical impact and relationship with key genomic alterations in prostate cancer, AQP5 expression was analyzed by...

journal_title：Human pathology

authors： Pust A,Kylies D,Hube-Magg C,Kluth M,Minner S,Koop C,Grob T,Graefen M,Salomon G,Tsourlakis MC,Izbicki J,Wittmer C,Huland H,Simon R,Wilczak W,Sauter G,Steurer S,Krech T,Schlomm T,Melling N

更新日期：2016-02-01 00:00:00

abstract：:A case of hemangiopericytoma arising in the esophagus is described. The light microscopic features were typical, and ultrastructural examination confirmed the presence of pericyte-like cells and excluded smooth muscle and fibroblastic differentiation. Areas of necrosis and a focus of mitotic activity within the tumor ...

journal_title：Human pathology

authors： Burke JS,Ranchod M

更新日期：1981-01-01 00:00:00

abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...

journal_title：Human pathology

authors： Schwarz J,Ayim A,Schmidt A,Jäger S,Koch S,Baumann R,Dünne AA,Moll R

更新日期：2006-05-01 00:00:00

abstract：:Diffuse gastric cancer, characterized by poorly cohesive, diffusely infiltrating cells with no or little gland formation, is known to show several morphologic variants, but their prognostic value, if any, is poorly documented. In this article, 119 cases of invasive (T1b to T4) diffuse gastric cancer, which had undergo...

journal_title：Human pathology

authors： Chiaravalli AM,Klersy C,Tava F,Manca R,Fiocca R,Capella C,Solcia E

更新日期：2009-11-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its...

journal_title：Human pathology

authors： Haffner MC,Kronberger IE,Ross JS,Sheehan CE,Zitt M,Mühlmann G,Ofner D,Zelger B,Ensinger C,Yang XJ,Geley S,Margreiter R,Bander NH

更新日期：2009-12-01 00:00:00

abstract：:Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...

journal_title：Human pathology

authors： Loda M

更新日期：1994-06-01 00:00:00

abstract：:Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...

journal_title：Human pathology

authors： Olar A,He D,Florentin D,Ding Y,Ayala G

更新日期：2014-07-01 00:00:00

abstract：:A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...

journal_title：Human pathology

authors： Asada Y,Marutsuka K,Mitsukawa T,Kuribayashi T,Taniguchi S,Sumiyoshi A

更新日期：1996-05-01 00:00:00

abstract：:Because infants rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourag...

journal_title：Human pathology

authors： Donnelly WH,Hawkins H

更新日期：1987-01-01 00:00:00

abstract：:The SHH signaling pathway is critical for gastrointestinal development and organic patterning, and dysregulation of SHH pathway molecules has been detected in multiple gastrointestinal neoplasms. This study investigated the role of the SHH signaling pathway in PJS. Expression of SHH, PTCH, and GLI1 was examined by rea...

journal_title：Human pathology

authors： Xu X,Su J,Li R,Wang Y,Zeng D,Wu B

更新日期：2016-04-01 00:00:00

abstract：:Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...

journal_title：Human pathology

authors： Azmahani A,Nakamura Y,Ozawa Y,McNamara KM,Fujimura T,Haga T,Hashimoto A,Aiba S,Sasano H

更新日期：2015-11-01 00:00:00

abstract：:This article describes a case of lymphomatoid granulomatosis without active pulmonary involvement of stigmata of healed granulomatous lesions in the lungs. The patient had ischemic segmental colitis due to mesenteric arterial intimal fibrosis, which we interpreted as spontaneously regressed granulomatous involvement o...

journal_title：Human pathology

authors： Singh G,Hellstrom HR

更新日期：1978-05-01 00:00:00

abstract：:Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...

journal_title：Human pathology

authors： McCullough J

更新日期：1983-03-01 00:00:00

abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...

journal_title：Human pathology

authors： Ohno Y,Kanematsu T

更新日期：1998-10-01 00:00:00