Distribution of monoclonal antiferritin antibody in Kaposi's sarcoma, Hodgkin's disease, and hepatocellular carcinoma.

Abstract:

:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy when radiolabeled in Hodgkin's disease and hepatoma. In this immunohistochemical study, we investigated the distribution of ferritin in tumors from 6 patients with Kaposi's sarcoma, 12 patients with Hodkgin's disease, and 9 patients with hepatoma, as well as in selected normal tissues. We found that the monoclonal antiferritin antibody binds primarily to histiocytes in samples from Kaposi's sarcoma and Hodgkin's disease. One hepatocellular carcinoma showed diffuse cytoplasmic staining with ferritin. Deposition of the monoclonal antibody was not detectable in the remaining hepatocellular carcinoma samples.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJ

doi

10.1053/hupa.2003.62

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

381-4

issue

4

eissn

0046-8177

issn

1532-8392

pii

S0046817703000170

journal_volume

34

pub_type

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