Abstract:
:The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy when radiolabeled in Hodgkin's disease and hepatoma. In this immunohistochemical study, we investigated the distribution of ferritin in tumors from 6 patients with Kaposi's sarcoma, 12 patients with Hodkgin's disease, and 9 patients with hepatoma, as well as in selected normal tissues. We found that the monoclonal antiferritin antibody binds primarily to histiocytes in samples from Kaposi's sarcoma and Hodgkin's disease. One hepatocellular carcinoma showed diffuse cytoplasmic staining with ferritin. Deposition of the monoclonal antibody was not detectable in the remaining hepatocellular carcinoma samples.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Yuen AR,Higgins JP,Baker R,Kamel OW,Warnke RA,Knox SJdoi
10.1053/hupa.2003.62subject
Has Abstractpub_date
2003-04-01 00:00:00pages
381-4issue
4eissn
0046-8177issn
1532-8392pii
S0046817703000170journal_volume
34pub_type
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