Expression of vascular endothelial growth factor (VEGF) in human thyroid neoplasms.

abstract：:Aberrations of the long arm of chromosome 13 are common in prostate cancer and were initially attributed to alterations of the RB1 gene in band q14 of the chromosome. However, prostate tumors generally yield normal p110RB1 nuclear staining despite loss of heterozygosity (LOH) at the RB1 locus. Our previous analysis of...

journal_title：Human pathology

authors： Latil A,Bièche I,Pesche S,Volant A,Valèri A,Fournier G,Cussenot O,Lidereau R

更新日期：1999-07-01 00:00:00

abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...

journal_title：Human pathology

authors： Berumen J,Unger ER,Casas L,Figueroa P

更新日期：1995-06-01 00:00:00

abstract：:In two patients with malignant germ cell tumors angiosarcoma developed through two apparently different mechanisms. In one case the angiosarcoma probably developed as a complication of therapeutic radiation, since radiation changes were demonstrated in tissue adjacent to the neoplasm and since the angiosarcoma was not...

journal_title：Human pathology

authors： Ulbright TM,Clark SA,Einhorn LH

更新日期：1985-03-01 00:00:00

abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...

journal_title：Human pathology

authors： Cornejo KM,Cheng L,Church A,Wang M,Jiang Z

更新日期：2016-03-01 00:00:00

abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...

journal_title：Human pathology

authors： Ohno Y,Kanematsu T

更新日期：1998-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid...

journal_title：Human pathology

authors： Salajegheh A,Pakneshan S,Rahman A,Dolan-Evans E,Zhang S,Kwong E,Gopalan V,Lo CY,Smith RA,Lam AK

更新日期：2013-10-01 00:00:00

abstract：:High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...

journal_title：Human pathology

authors： Roger P,Montcourrier P,Maudelonde T,Brouillet JP,Pages A,Laffargue F,Rochefort H

更新日期：1994-09-01 00:00:00

abstract：:A renal biopsy of a 57-year-old man with nephrotic syndrome revealed marked glomerular deposition of Congo red-positive, bire-fringent material characteristic for amyloid. Ultrastructurally, however, this material is composed of nonbranching, haphazardly arranged fibrils of approximately three times the thickness of t...

journal_title：Human pathology

authors： Yoshikawa Y,Truong LD,Mattioli C,Cartwright J Jr

更新日期：1990-08-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...

journal_title：Human pathology

authors： Di Sabatino A,Rovedatti L,Rosado MM,Carsetti R,Corazza GR,MacDonald TT

更新日期：2009-05-01 00:00:00

abstract：:Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...

journal_title：Human pathology

authors： Loken SD,Demetrick DJ

更新日期：2005-09-01 00:00:00

abstract：:Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determ...

journal_title：Human pathology

authors： Lininger RA,Park WS,Man YG,Pham T,MacGrogan G,Zhuang Z,Tavassoli FA

更新日期：1998-10-01 00:00:00

abstract：:A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...

journal_title：Human pathology

authors： Baněčková M,Martínek P,Skálová A,Mezencev R,Hadravský L,Michal M,Švajdler M

更新日期：2020-05-01 00:00:00

abstract：:Molecular apocrine breast cancer (MABC) is a molecular subtype with a poor prognosis, and there is urgent need to find new therapeutic targets. Epidermal growth factor receptor (EGFR) plays an important part in regulating the biological behavior of tumor cells, and EGFR-targeted drugs have already been used in therapy...

journal_title：Human pathology

authors： Liu X,Feng C,Liu J,Liu J,Li C,Xu C,Niu Y

更新日期：2018-07-01 00:00:00

abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...

journal_title：Human pathology

authors： Lee MC,Kim GM,Woo YJ,Kim MK,Kim JH,Nam SC,Suh JJ,Chung WK,Lee JS,Kim HI,Choi HY,Kim SU

更新日期：2001-06-01 00:00:00

abstract：:We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But un...

journal_title：Human pathology

authors： Bissig H,Staehelin F,Tolnay M,Avoledo P,Richter J,Betts D,Bruder E,Kühne T

更新日期：2002-10-01 00:00:00

abstract：:In 1999, the World Health Organization (WHO) published a new classification of papillary urothelial tumors of the urinary bladder. Intended to represent a reproducible, easy-to-use classification system that better separates patients with true malignancies (bladder cancer) from those patients who are at an increased r...

journal_title：Human pathology

authors： Helpap B,Köllermann J

更新日期：2000-06-01 00:00:00

abstract：:Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis. Survivin and hedgehog proteins, including sonic hedgehog, patched, and smoothened, inhibit apoptosis, with hedgehog proteins forming a signal transduction cascade implicated in digestive cancers. This s...

journal_title：Human pathology

authors： Parfitt JR,Driman DK

更新日期：2007-05-01 00:00:00

abstract：:The expression of the proteins encoded by the ras, myc, and erb B-2 oncogenes was examined in 63 paraffin-embedded human cholangiocarcinomas of Thai and English origin using immunohistochemistry. The observed distributions were compared with oncogene expression in a series of human hepatocellular carcinomas. In an att...

journal_title：Human pathology

authors： Voravud N,Foster CS,Gilbertson JA,Sikora K,Waxman J

更新日期：1989-12-01 00:00:00

abstract：:Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...

journal_title：Human pathology

authors： García JJ,Jin L,Jackson SB,Larsen BT,Lewis JE,Sukov WR,Roden AC

更新日期：2015-03-01 00:00:00

abstract：:Tumor proliferation in bladder cancer is associated with tumor behavior. To assess the association between Ki-67 labeling index (LI), p53, and c-erbB-2 overexpression, formalin-fixed tissue samples of 160 patients with transitional cell carcinoma (TCC) of the urinary bladder were studied by immunohistochemistry. Ki-67...

journal_title：Human pathology

authors： Moch H,Sauter G,Mihatsch MJ,Gudat F,Epper R,Waldman FM

更新日期：1994-12-01 00:00:00

abstract：:It has been suggested that atypical adenomatous hyperplasia (AAH) may be a precursor of peripheral adenocarcinoma of the lung. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA onto chromosomal ends. Its activity is believed to be crucial for cellular immortality, and it is thought to participate...

journal_title：Human pathology

authors： Nakanishi K,Kawai T,Kumaki F,Hirot S,Mukai M,Ikeda E

更新日期：2002-07-01 00:00:00

abstract：:This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The ...

journal_title：Human pathology

authors： Hachitanda Y,Hata J

更新日期：1996-11-01 00:00:00

abstract：:Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...

journal_title：Human pathology

authors： Giltman L,Alderete M,Minkowitz S

更新日期：1977-11-01 00:00:00

abstract：:The DNA content of both fresh and formalin-fixed, paraffin-embedded tissues from 30 solid neoplasms was analyzed by flow cytometry. Cells from a single paraffin block of each tumor were disaggregated according to the method of Hedley et al. Cells were sampled from multiple sites of each fresh specimen. Fresh and depar...

journal_title：Human pathology

authors： Frierson HF Jr

更新日期：1988-03-01 00:00:00

abstract：:In a review of pediatric autopsies from 1951 to 1985, we identified 40 cases in which pancreatitis was diagnosed pathologically. Twenty-six of these patients were under 4 years of age, and the male-to-female ratio was 1.5. Six groups of patients were identified: 10 with hepatobiliary disease, including 9 with biliary ...

journal_title：Human pathology

authors： Nguyen T,Abramowsky C,Ashenburg C,Rothstein F

更新日期：1988-03-01 00:00:00

abstract：:Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that has morphologic features similar to secretory carcinoma of the breast and that also harbors the same ETV6 translocation. Diffuse mammaglobin and S-100 immunoreactivity are used to differentiate MASC from its morphologic mimic...

journal_title：Human pathology

authors： Patel KR,Solomon IH,El-Mofty SK,Lewis JS Jr,Chernock RD

更新日期：2013-11-01 00:00:00

abstract：:Glucose transporter (GLUT)-1 is expressed in malignant tumors and correlated with poor outcome in several cancers. Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. We examined GLUT-1 and GLUT-2 expression in 149 intrahepatic cholangiocarc...

journal_title：Human pathology

authors： Kubo Y,Aishima S,Tanaka Y,Shindo K,Mizuuchi Y,Abe K,Shirabe K,Maehara Y,Honda H,Oda Y

更新日期：2014-08-01 00:00:00

abstract：:The national decline in hospital autopsy cases negatively impacts physician education and medical quality control to an unknown degree. The current non-medicolegal autopsy rate is less than 5% of hospital deaths. This study compares internal medicine and pathology resident physician perceptions of the autopsy, includi...

journal_title：Human pathology

authors： Hull MJ,Nazarian RM,Wheeler AE,Black-Schaffer WS,Mark EJ

更新日期：2007-02-01 00:00:00

abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...

journal_title：Human pathology

authors： Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto F

更新日期：1994-09-01 00:00:00

abstract：:It is impossible to overstate the importance of XML (eXtensible Markup Language) as a data organization tool. With XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure. The purpose of thi...

journal_title：Human pathology

authors： Berman JJ

更新日期：2005-02-01 00:00:00