Abstract：
:This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The primary sites were adrenal in 34 cases, retroperitoneum in two, mediastinum in one, and unknown in eight; the liver was involved in 24 of 31 cases, the bone marrow in 11 of 27, and the skin in 4 of 29. According to the histopathological evaluation (Shimada classification), 43 IVS-NB tumors had a favorable histology, and 2 cases showed an unfavorable histology. Three patients died of progressive disease and six of indirect tumor death. Among these three deceased cases with tumor progression, two cases showed unfavorable histology, and one case had amplified N-myc (20 copies). These data suggest that most IVS-NB can be described as a tumor presenting characteristic dissemination pattern in the younger age group, having a favorable histology and showing an excellent outcome of the patients. However, poor prognosis group in stage IVS does exist, and this group could be detected histopathologically and biologically.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Hachitanda Y,Hata Jdoi
10.1016/s0046-8177(96)90304-4subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1135-8issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(96)90304-4journal_volume
27pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (rang...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.007
更新日期：2020-12-01 00:00:00
abstract：:Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00336-8
更新日期：2003-09-01 00:00:00
abstract：:Glomerulonephritis (GN) characterized by immune complex deposits typical of postinfectious GN but with a paucity or absence of overt clinical symptoms and/or urinary abnormalities may occur after a group A streptococcus infection. The overall incidence of this type of subclinical GN is not known. To address this quest...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2003.53
更新日期：2003-01-01 00:00:00
abstract：:A 35-year-old white Jewish homosexual man who had undergone surgery and chemotherapy for an embryonal carcinoma of the testis subsequently developed Kaposi's sarcoma. The neoplasm involved the skin as well as visceral tissues. Tissue derived from a biopsy specimen of one of the skin lesions was used in the in situ hyb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80063-4
更新日期：1982-10-01 00:00:00
abstract：:We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90210-4
更新日期：1989-01-01 00:00:00
abstract：:Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the Ameri...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.03.014
更新日期：2004-07-01 00:00:00
abstract：:Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.008
更新日期：2015-02-01 00:00:00
abstract：:Four human fetuses with the limb body wall malformation complex, also known as the amniotic band syndrome, were examined. Besides malformations of the body wall and the limb(s), anomalies of the internal organs were found in three fetuses, suggesting a disturbance of normal morphogenesis before the fifth week of devel...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90225-6
更新日期：1989-11-01 00:00:00
abstract：:Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90078-4
更新日期：1991-04-01 00:00:00
abstract：:Endomyocardial biopsies from right, left, or both ventricles were performed in 13 angiographically documented cases of endomyocardial fibrosis. The endocardium was appreciably thickened due to acellular hyalinized collagen tissue in all cases. Variable amounts of elastic tissue intimately admixed with fibrous tissue w...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90007-6
更新日期：1990-06-01 00:00:00
abstract：:Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.06.016
更新日期：2005-09-01 00:00:00
abstract：:This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.11.005
更新日期：2005-02-01 00:00:00
abstract：:A large hepatic tumor was detected in the noncirrhotic liver of a 27-year-old female patient. The tumor was radiologically characterized by a peripheral mass encircling a central ovoid tumor, and was resected by an extended right hemihepatectomy. Histologic examination revealed that the peripheral and major component ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125380
更新日期：2002-07-01 00:00:00
abstract：:Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Lymphoplasmacytic infiltrates in the breast, a modified skin appendage, include lymphocytic lobulitis, other nonspecific benign proliferations, and mucosa-associated lymphoid tissue (MALT)-type lymphoma. Distinguishing these entities, all of which may be B-cell rich and may have associated sclerosis, can be difficult....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.04.006
更新日期：2015-08-01 00:00:00
abstract：:We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90406-2
更新日期：1996-07-01 00:00:00
abstract：:Benign chondroblastoma is an unusual solitary bone tumor occurring usually in the second decade in a long bone. The tumor is often sited on epiphyseal cartilages. Very few examples of malignant variants have been documented, although local recurrence of benign tumors is not unusual. We wish to report a patient who dev...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80014-1
更新日期：1980-05-01 00:00:00
abstract：:To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the orig...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.11.008
更新日期：2004-05-01 00:00:00
abstract：:The clinical spectrum of coronavirus disease 2019 is getting wider with the exponential increase of patients worldwide. Initially described with flu-like symptoms, variable cutaneous manifestations have been reported, with only few histopathological descriptions. Detection of the virus in cutaneous samples has been as...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.10.011
更新日期：2021-01-01 00:00:00
abstract：:Extramammary Paget disease (EMPD) has been known to frequently express androgen receptor (AR). Therefore, androgens could play roles in the biological behavior of Paget cells. 5α-Reductase (5α-red) types 1 and 2 and 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) are pivotal in situ regulators of androgen productio...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.007
更新日期：2015-11-01 00:00:00
abstract：:Intrasinusoidal infiltration of bone marrow (BM) may accompany several malignant lymphoproliferative disorders. In small B-cell lymphomas, this pattern is considered specific for splenic marginal zone lymphoma (SMZL) when exclusive or prominent, although it may occur in other subtypes of non-Hodgkin's lymphomas (NHLs)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00286-7
更新日期：2003-08-01 00:00:00
abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.06.002
更新日期：2013-03-01 00:00:00
abstract：:Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of the platelet surface and the membranes enclosing storage organelles. It is not surprising, therefore, that membrane defects are common in platelets from patients with inherited h...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(87)80331-3
更新日期：1987-02-01 00:00:00
abstract：:Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90124-7
更新日期：1999-04-01 00:00:00
abstract：:Topoisomerases are ubiquitous nuclear enzymes that regulate DNA structure in eukaryotic cells. The role of topoisomerase IIIβ, the newest member of the topoisomerase family, in the clinical outcome of breast cancer is still poorly understood. This study aims to investigate the immunoexpression of topoisomerase IIIβ in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.01.027
更新日期：2010-11-01 00:00:00
abstract：:A case of hemangiopericytoma arising in the esophagus is described. The light microscopic features were typical, and ultrastructural examination confirmed the presence of pericyte-like cells and excluded smooth muscle and fibroblastic differentiation. Areas of necrosis and a focus of mitotic activity within the tumor ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80248-1
更新日期：1981-01-01 00:00:00
abstract：:Schistosoma haematobium infection is a common occurrence in Africa and the Middle East and is the world's leading cause of hematuria. Since more North Americans are venturing into endemic areas and more residents of endemic areas are seeking medical care in North America, pathologists must be able not only to diagnose...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80456-7
更新日期：1986-04-01 00:00:00
abstract：:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.08.003
更新日期：2020-10-01 00:00:00
abstract：:A carcinoma of the urinary bladder with a distinct choriocarcinomatous component that developed in a postmenopausal woman was associated with high titers of circulating chorionic gonadotropin. The diagnosis was supported by histochemical demonstration of human chorionic gonadotropin in syncytial tumor giant cells and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80173-2
更新日期：1984-08-01 00:00:00
abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80143-3
更新日期：1982-01-01 00:00:00
