DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis.

Abstract:

:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns 2 +/- 18.0; mean +/- standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 +/- 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto F

doi

10.1016/0046-8177(94)90015-9

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

936-9

issue

9

eissn

0046-8177

issn

1532-8392

pii

0046-8177(94)90015-9

journal_volume

25

pub_type

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