Abstract:
:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns 2 +/- 18.0; mean +/- standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 +/- 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto Fdoi
10.1016/0046-8177(94)90015-9subject
Has Abstractpub_date
1994-09-01 00:00:00pages
936-9issue
9eissn
0046-8177issn
1532-8392pii
0046-8177(94)90015-9journal_volume
25pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80017-4
更新日期:1985-03-01 00:00:00
abstract::We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces wer...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.020
更新日期:2017-03-01 00:00:00
abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.04.016
更新日期:2017-07-01 00:00:00
abstract::We report four unusual cases of hyalinizing trabecular thyroid tumors, three of which displayed capsular and/or blood vessel invasion and were classified as minimally invasive carcinomas. These three patients were all euthyroid women aged 18, 39, and 62 years. The youngest patient also had familial polyposis, while th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90277-1
更新日期:1994-02-01 00:00:00
abstract::Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90323-u
更新日期:1992-06-01 00:00:00
abstract::Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90023-5
更新日期:1998-12-01 00:00:00
abstract::Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and a known mediator of glucocorticoid-regulated inflammatory responses. Using a combined multiple high-throughput approach, we recently identified a reduced expression of ANXA1 in human breast cancer. The finding was confirmed at the gene level by quan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.001
更新日期:2006-12-01 00:00:00
abstract::We report the morphonuclear characteristics of normal (13 cases), benign (ie, chronic) pancreatitis (six cases), and neoplastic (ie, ductal) adenocarcinoma (22 cases) tissues of the pancreas. This description is based on computerized cell image analysis, which permits the determination of parameters related to the mor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90287-d
更新日期:1992-11-01 00:00:00
abstract::The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80077-5
更新日期:1984-05-01 00:00:00
abstract::Because infants rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourag...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80194-6
更新日期:1987-01-01 00:00:00
abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2006.10.006
更新日期:2007-04-01 00:00:00
abstract::Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80243-8
更新日期:1982-12-01 00:00:00
abstract::Multifocal/multicentric breast cancers are common. However, investigations of biomarkers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 in individual tumor foci of such cancers are rare. This study was designed to evaluate the status of the hormone receptors, human epide...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.08.026
更新日期:2012-01-01 00:00:00
abstract::Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.015
更新日期:2012-09-01 00:00:00
abstract::Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90104-0
更新日期:1997-02-01 00:00:00
abstract::Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.09.011
更新日期:2015-02-01 00:00:00
abstract::A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2020.03.007
更新日期:2020-05-01 00:00:00
abstract::This study assessed squamous cell papillomas of the human esophagus for the presence of human papillomavirus (HPV) and correlated the results with histological features. Twenty-three lesions obtained by endoscopic biopsy from 17 patients were studied, first by in situ hybridization (ISH) for HPV types 6-11, 16-18, 18,...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90128-7
更新日期:1994-05-01 00:00:00
abstract::In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, lam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80251-8
更新日期:2000-03-01 00:00:00
abstract::Cytogenetic analysis of short-term cultures from 34 benign colorectal polyps, all histologically verified as adenomas, revealed clonal chromosome aberrations in 21 of them. Eight polyps had structural rearrangements, whereas only numerical changes were found in 13. A combination of structural and numerical chromosomal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90314-7
更新日期:1996-11-01 00:00:00
abstract::Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.006
更新日期:2013-10-01 00:00:00
abstract::(90)Yttrium (Therasphere) microspheres administered via hepatic artery are a valuable option for treatment of hepatocellular carcinoma. This therapy targets tumor nodules while largely sparing hepatic parenchyma. This retrospective study examines liver explants from 13 adult patients with hepatocellular carcinoma who ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.06.024
更新日期:2009-01-01 00:00:00
abstract::Reactive bone marrow mast cells reliably lack the morphologic, immunophenotypic, and molecular features of systemic mastocytosis (SM). We report two unusual cases of acquired aplastic anemia (AA) in which multifocal aggregates of bone marrow mast cells fulfilled morphologic and immunophenotypic criteria for SM accordi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.08.002
更新日期:2014-02-01 00:00:00
abstract::Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.10.004
更新日期:2005-01-01 00:00:00
abstract::A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90030-8
更新日期:1999-10-01 00:00:00
abstract::Overexpression of mitotic arrest deficient 2 (MAD2) and/or cell division cycle 20 (CDC20) in the spindle assembly checkpoint leads to chromosomal instability and aneuploidy. Cell-in-cell (CIC) structures are formed by the process where cancer or immune cells are internalized into adjacent host cancer cells. Here, we i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.10.029
更新日期:2019-03-01 00:00:00
abstract::Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.017
更新日期:2011-12-01 00:00:00
abstract::Bone Marrow Transplant (BMT) is a critical therapeutic intervention for a variety of diseases occurring in the pediatric patient. Complications of allogeneic BMT include graft-versus-host disease (GVHD), infection, drug toxicity, thrombotic microangiopathy, and veno-occlusive disease. With solid organ transplantation,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90132-6
更新日期:1999-07-01 00:00:00
abstract::The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90238-x
更新日期:1992-02-01 00:00:00
abstract::A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.03.005
更新日期:2020-06-01 00:00:00