Abstract:
:There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurrent biopsies with invasive breast tumors. Consecutive ipsilateral concurrent biopsies with invasive breast tumors were identified retrospectively. Biomarker results, histologic grade and histologic subtype among the tumors in concurrent samples were compared. ER, PR, and HER2 expression was different in 3 (2.5%), 11 (9.2%) and 7 (5.9%) cases, respectively. All ER-discordant cases were sets of ER-negative (ER-) and weak-low ER-positive (ER+), ductal subtype and histologic grade 2 or 3 tumors. All PR-discordant cases were ER+, and comprised of histologic grades 1 to 3 ductal as well as lobular tumors. All HER2 discordant cases were histologic grade 2 to 3 ductal tumors. Biomarker discordance was independent of grade and subtype discordance. We found very low biomarker discordance among tumors in concurrent samples from ipsilateral breast. Our results suggest that ER and HER2 discordance in concurrent samples is predictable. ER discordance is present only in a setting of low ER+ tumors. Low-grade ductal and/or lobular tumors are ER and HER2 concordant. HER2 discordance is noted in grade 2 to 3 ductal tumors only. Histologic subtype and grade may guide extent of biomarker testing in concurrent ipsilateral breast biopsies.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Singh K,Wang Y,Marketkar S,Kalife ET,Steinhoff MMdoi
10.1016/j.humpath.2017.04.016subject
Has Abstractpub_date
2017-07-01 00:00:00pages
123-132eissn
0046-8177issn
1532-8392pii
S0046-8177(17)30135-1journal_volume
65pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::We have recently noted a hitherto undescribed hepatic hemosiderosis confined to endothelial cells of the portal tract in chronic viral hepatitis. In this study, this lesion was surveyed in 156 liver biopsy specimens from patients with chronic hepatitis C and in 21 liver biopsy specimens from patients with chronic hepa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90269-4
更新日期:1995-10-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a commonly occurring tumor in southern China. Although several causative factors have now been recognized, the genetic basis underlying its tumorigenesis is still unclear. To identify potential chromosomal aberrations for further investigations, comparative genomic hybridization (CGH)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80216-6
更新日期:2000-02-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.05.028
更新日期:2014-01-01 00:00:00
abstract::GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.05.022
更新日期:2013-11-01 00:00:00
abstract::Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.7894
更新日期:2000-06-01 00:00:00
abstract::In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.04.010
更新日期:2016-09-01 00:00:00
abstract::Thirty cases of ductal carcinoma in situ (DCIS) of the breast, showing histological microcalcifications, were studied to clarify their mechanism of formation. Undecalcified sections revealed three types of calcium precipitates: type I and II granular calcifications (GCs) and laminar calcifications (LCs). In type I GCs...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90372-x
更新日期:1996-02-01 00:00:00
abstract::Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.039
更新日期:2017-03-01 00:00:00
abstract::Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.10.018
更新日期:2017-02-01 00:00:00
abstract::Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.08.011
更新日期:2010-02-01 00:00:00
abstract::Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.012
更新日期:2004-10-01 00:00:00
abstract::CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.29678
更新日期:2001-12-01 00:00:00
abstract::The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.07.019
更新日期:2011-04-01 00:00:00
abstract::This article describes a case of lymphomatoid granulomatosis without active pulmonary involvement of stigmata of healed granulomatous lesions in the lungs. The patient had ischemic segmental colitis due to mesenteric arterial intimal fibrosis, which we interpreted as spontaneously regressed granulomatous involvement o...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80096-3
更新日期:1978-05-01 00:00:00
abstract::Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a h...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80254-3
更新日期:1984-11-01 00:00:00
abstract::Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.04.039
更新日期:2019-01-01 00:00:00
abstract::Mammary analogue secretory carcinoma is a recently described salivary gland neoplasm defined by ETV6-NTRK3 gene fusion. Mammary analogue secretory carcinoma's morphology is not entirely specific and overlaps with other salivary gland tumors. Documenting ETV6 rearrangement is confirmatory, but most laboratories are not...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.017
更新日期:2013-10-01 00:00:00
abstract::Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.022
更新日期:2012-09-01 00:00:00
abstract::Pulmonary endodermal tumor resembling fetal lung describes an uncommon neoplasm of the lung which also has been referred to as pulmonary blastoma and adenocarcinoma of fetal lung type. We describe five cases which fall within a narrow band on the spectrum of pulmonary neoplasms with both epithelial and mesenchymal fea...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90145-u
更新日期:1990-11-01 00:00:00
abstract::Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2012.01.015
更新日期:2012-11-01 00:00:00
abstract::Four cases of clear cell lymphoma were studied by means of light and electron microscopy, enzyme-histochemistry, and E- and EAC-rosette formation. On light microscopic examination the tumors were seen to be composed mainly of round, oval, or slight irregular cells with water-clear, abundant cytoplasm. The neoplastic c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80258-2
更新日期:1988-07-01 00:00:00
abstract::Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90145-0
更新日期:1995-04-01 00:00:00
abstract::Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90287-2
更新日期:1997-01-01 00:00:00
abstract::Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.02.002
更新日期:2014-06-01 00:00:00
abstract::Serous surface carcinoma (SSC) is a neoplasm histologically indistinguishable from typical serous carcinomas that arise from the ovary but has a distinct clinical presentation. It is characterized by widespread peritoneal dissemination at presentation, but the ovaries are grossly normal in size and shape. If the carci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90277-0
更新日期:1999-02-01 00:00:00
abstract::Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80031-8
更新日期:1983-03-01 00:00:00
abstract::Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.06.009
更新日期:2005-08-01 00:00:00
abstract::To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.04.024
更新日期:2014-11-01 00:00:00
abstract::Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.05.022
更新日期:2016-10-01 00:00:00
abstract::Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.033
更新日期:2017-10-01 00:00:00