Abstract:
:The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative for keratins of different molecular weights (45, 55, and 63 kilodaltons) that are characteristically present in mesothelial cells. Ultrastructurally, the cells most closely resembled mesenchymal cells of the fibroblastic type. These findings are in accordance with recent theories that relate the derivation of localized fibrous mesotheliomas to nonmesothelial cells, including subpleural connective tissue. Based on differences in immunohistochemical staining, the tumors appear to be unrelated to diffuse malignant mesotheliomas.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Said JW,Nash G,Banks-Schlegel S,Sassoon AF,Shintaku IPdoi
10.1016/s0046-8177(84)80077-5subject
Has Abstractpub_date
1984-05-01 00:00:00pages
440-3issue
5eissn
0046-8177issn
1532-8392pii
S0046-8177(84)80077-5journal_volume
15pub_type
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