Abstract：
:In an attempt to identify patients best suited for limited surgery as well as those at risk for recurrence and increased mortality, the authors reviewed the clinical and pathologic features of 130 patients who had undergone partial mastectomy as primary treatment for breast cancer (adjuvant therapy was administered only after disease recurrence). Patients were followed up for 57 to 128 months (mean, 85 months). Univariate and multivariate analyses were performed for the entire group and repeated for the large subgroup of patients with infiltrating ductal cancer, not otherwise specified. Three features were independently significant in correlating with poor survival and/or tumor recurrence: lymph node metastasis, mitotic rate, and nuclear atypia. Combinations of these factors further separated survivors from non-survivors. These prognostically significant pathologic features may be helpful in both selecting patients for partial mastectomy and identifying those who may require adjuvant therapy.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Lash RH,Bauer TW,Hermann RE,Esselstyn CBdoi
10.1016/s0046-8177(86)80202-7subject
Has Abstractpub_date
1986-08-01 00:00:00pages
813-22issue
8eissn
0046-8177issn
1532-8392pii
S0046-8177(86)80202-7journal_volume
17pub_type
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